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Albenza
Albenza (albendazole) is an anthelmintic (anti-parasitic) medication used to treat a variety of parasitic infections. It is effective against infections caused by certain worms and parasites, including neurocysticercosis, hydatid disease, and various types of intestinal worms. Albenza works by inhibiting the uptake of glucose by the parasites, leading to their eventual death.
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Frequently Asked Questions
How long does it take for Albenza to work?
The time it takes for Albenza to work can vary based on the type of infection being treated. Some patients may start to feel better within a few days, while complete resolution may take several weeks.
Can I take Albenza if I am pregnant?
No, Albenza is contraindicated during pregnancy due to potential risks to the fetus. Women should use effective contraception while taking this medication.
What should I do if I miss a dose of Albenza?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Are there any dietary restrictions while taking Albenza?
It is recommended to take Albenza with food to improve absorption, but no specific dietary restrictions are required.
Can I stop taking Albenza if I feel better?
It is important to complete the full course of treatment as prescribed by your healthcare provider, even if you feel better, to ensure the complete eradication of the infection.
Comprehensive Drug Guide
How Does Albenza Work?
Albenza works by binding to the beta-tubulin of the parasite's microtubules, disrupting their function. This action prevents the parasites from taking up glucose and leads to their death. By inhibiting cellular division and metabolism, Albenza effectively reduces the burden of parasitic infections.
Common Dosages
- Tablets: 400 mg
Typical Dosing
- For neurocysticercosis, the typical dose is 15 mg/kg per day for 8 to 30 days, depending on the severity of the condition.
- For hydatid disease, the recommended dosage is 10 to 15 mg/kg per day, divided into two doses, for 28 days, followed by a similar treatment course after a break.
- For other intestinal infections, the dose may vary based on the type of parasite being treated.
Typical Dosing
FDA Approved Indications
- Neurocysticercosis caused by Taenia solium
- Hydatid disease caused by Echinococcus granulosus
- Other intestinal infections caused by various worms (e.g., pinworm, hookworm, whipworm)
Who Shouldn't Take Albenza?
- Known hypersensitivity to albendazole or any components of the formulation
- Pregnancy (as it may harm the developing fetus)
Advice From The Pharmacist
- Take Albenza exactly as prescribed, with food to enhance absorption, especially for the tablet formulation.
- Follow up with your healthcare provider for monitoring and to ensure the effectiveness of treatment.
- Report any unusual symptoms or side effects, such as abdominal pain or severe allergic reactions, to your healthcare provider promptly.
Side Effects of Albenza
Common Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Liver dysfunction (elevated liver enzymes)
- Severe allergic reactions (e.g., rash, itching, swelling, or difficulty breathing)
Risks and Warnings of Albenza
- Liver Function: Regular monitoring of liver function tests may be necessary during treatment, especially in patients with pre-existing liver conditions.
- Blood Dyscrasias: Albendazole can affect blood cell counts; monitoring may be required for signs of bone marrow suppression.
- Pregnancy: Women of childbearing age should use effective contraception while taking Albenza, and it is contraindicated during pregnancy.
Interactions with Albenza
Common Drug Interactions
- Cimetidine: May increase the plasma levels of albendazole, leading to potential side effects.
- Other anti-parasitics: Caution should be exercised when using other anthelmintics concurrently, as this may affect treatment efficacy or safety.
Alternatives to Albenza
- Other anthelmintic medications: Such as mebendazole or ivermectin may be considered for specific parasitic infections.
- Combination therapy: In certain cases, a combination of medications may be used for more effective treatment of multi-parasitic infections.