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Aklief
Aklief (generic name: trifarotene) is a topical retinoid used for the treatment of acne vulgaris in patients aged 9 years and older. It is specifically formulated to treat both facial and truncal (chest, shoulders, and back) acne. Aklief belongs to a class of medications known as retinoids, which are derivatives of vitamin A and work by regulating the growth of skin cells. It is the first new topical retinoid approved for acne treatment in over 20 years and is highly effective in targeting acne at its root cause by addressing both inflammatory and non-inflammatory acne lesions.
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Frequently Asked Questions
How long does it take for Aklief to work?
Most patients begin to see improvement in their acne within 8-12 weeks of consistent use. Full results may take longer, and it's important to continue using the medication as prescribed, even if the acne does not improve right away.
Can I use Aklief if I have sensitive skin?
Aklief may cause initial irritation, especially in those with sensitive skin. If you have sensitive skin, start by applying the cream every other night and gradually increase to nightly use as your skin adjusts. Using a moisturizer can also help reduce irritation.
Can Aklief be used with other acne medications?
Aklief can be used with other treatments like oral antibiotics, but combining it with other topical acne treatments, such as benzoyl peroxide or salicylic acid, should only be done under a healthcare provider’s guidance to avoid excessive dryness or irritation.
Do I need to apply sunscreen while using Aklief?
Yes, Aklief can make your skin more sensitive to the sun, increasing the risk of sunburn. Always apply a broad-spectrum sunscreen (SPF 30 or higher) and avoid prolonged sun exposure.
Can I use Aklief during pregnancy?
Aklief is classified as a pregnancy category C drug, meaning it should be used with caution during pregnancy. Consult your healthcare provider if you are pregnant or planning to become pregnant while using Aklief.
Comprehensive Drug Guide
How Does Aklief Work?
Aklief works by binding to specific retinoic acid receptors (RARs) in the skin, primarily targeting RAR-γ, which is the most common retinoic acid receptor in the skin. This action helps normalize the shedding of dead skin cells, preventing the clogging of pores (which leads to acne) and reducing inflammation. Aklief helps prevent the formation of new acne lesions while also treating existing pimples, blackheads, and whiteheads.
Common Dosages
- Cream: 0.005% trifarotene
Typical Dosing
- Apply a thin layer of Aklief cream to the affected areas once daily in the evening. It should be applied to clean, dry skin, and only a small amount is needed for effective coverage of the entire face or body. Care should be taken to avoid the eyes, lips, and mucous membranes.
Typical Dosing
FDA Approved Indications
- The treatment of acne vulgaris (both inflammatory and non-inflammatory lesions) on the face and trunk in patients aged 9 years and older.
Who Shouldn't Take Aklief?
- Known hypersensitivity to trifarotene or any other ingredients in the formulation.
- Severe skin irritation or eczema, as the use of Aklief can exacerbate these conditions.
Advice From The Pharmacist
- Use sunscreen daily when using Aklief, as it can make your skin more sensitive to the sun. A broad-spectrum SPF of at least 30 is recommended.
- Avoid using other topical acne treatments unless directed by your healthcare provider, as combining treatments can cause excessive dryness and irritation.
- If you experience irritation, redness, or dryness, consider reducing the frequency of application and using a moisturizer to help alleviate symptoms.
- It can take 8-12 weeks to see the full effect of Aklief, so consistency is key.
Side Effects of Aklief
Common Side Effects
- Dryness or flakiness of the skin
- Redness or irritation, especially during the first few weeks of use
- Itching
Uncommon/Severe Side Effects
- Severe skin irritation
- Allergic reactions (such as rash, swelling, or difficulty breathing)
Risks and Warnings of Aklief
- Photosensitivity: Aklief can make the skin more sensitive to UV light, increasing the risk of sunburn. It is important to use sunscreen and protective clothing when outdoors.
- Irritation: Some patients may experience skin irritation during the first few weeks of treatment, which typically subsides as the skin adjusts to the medication. If irritation becomes severe, consult your healthcare provider for advice on adjusting the dosing schedule.
Interactions with Aklief
Common Drug Interactions
- Other topical treatments: Avoid using Aklief with other topical retinoids or acne treatments, such as benzoyl peroxide or salicylic acid, unless advised by a healthcare provider, as this may increase the risk of skin irritation.
- Medications that increase photosensitivity: Drugs like tetracycline antibiotics can increase the risk of sun sensitivity when used with Aklief.
Alternatives to Aklief
- Differin (adapalene): Another topical retinoid commonly used to treat acne, available over-the-counter in lower strengths.
- Tazorac (tazarotene): A prescription retinoid used for acne, as well as psoriasis, with a higher potency.
- Benzoyl peroxide: An over-the-counter acne treatment often used in combination with retinoids.
- Clindamycin: A topical antibiotic used for treating inflammatory acne.
