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Addyi
Addyi, the brand name for flibanserin, is a prescription medication used to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. It belongs to a class of drugs known as serotonin receptor agonists and antagonists. Unlike treatments that address physical aspects of sexual dysfunction, Addyi is designed to work on the brain's chemical balance to improve sexual desire. It is specifically intended for women who experience a persistent lack of sexual desire that causes personal distress or difficulty in relationships. Addyi helps manage this condition by altering the levels of neurotransmitters in the brain, which are involved in sexual motivation and response.
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Frequently Asked Questions
How long does it take for Addyi to start working?
It may take several weeks of consistent use for Addyi to improve sexual desire. If no improvement is seen after 8 weeks, you should consult your healthcare provider.
Can I drink alcohol while taking Addyi?
No, you should avoid alcohol while taking Addyi, as it can cause severe drops in blood pressure and fainting.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not take two doses at the same time to make up for a missed dose.
Can men use Addyi?
No, Addyi is specifically approved for use in premenopausal women with hypoactive sexual desire disorder (HSDD) and is not indicated for use in men.
How should I store Addyi?
Store Addyi at room temperature, away from moisture and heat, and keep it out of reach of children.
Is Addyi safe for long-term use?
Addyi is intended for long-term use if it proves effective. However, if there is no improvement after 8 weeks, it is generally recommended to discontinue use.
Comprehensive Drug Guide
How Does Addyi Work?
Addyi works by modulating the levels of certain neurotransmitters in the brain, specifically serotonin, dopamine, and norepinephrine. These chemicals are involved in regulating mood, motivation, and sexual desire. By increasing dopamine and norepinephrine levels (which are associated with sexual excitement) and reducing serotonin levels (which can inhibit sexual desire), Addyi helps restore a more balanced state that promotes increased sexual desire in women with HSDD.
Common Dosages
Addyi is typically available in the following form and strength:
- 100 mg tablet
The medication is taken once daily at bedtime to reduce the risk of side effects such as low blood pressure and fainting.
The typical dosing for Addyi is one 100 mg tablet taken once daily at bedtime. It is important to take the medication at the same time each day, and it should be taken consistently for several weeks to determine its effectiveness. If no improvement in sexual desire is noticed after 8 weeks, it is recommended to discontinue use and consult your healthcare provider.
Typical Dosing
FDA Approved Indications
Addyi is FDA-approved for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. It is intended for women who experience low sexual desire that is not caused by a medical condition, mental health issue, relationship problem, or the effects of a medication. There are no widely recognized off-label uses for Addyi, as its indication is specifically for this form of sexual dysfunction in women.
Who Shouldn't Take Addyi?
Addyi should not be used in individuals who:
- Have a history of hypersensitivity to flibanserin or any of its components.
- Are taking certain medications that can interact dangerously with Addyi, such as strong CYP3A4 inhibitors (e.g., certain antifungals or antibiotics).
- Have liver impairment, as this can increase the risk of serious side effects.
It is also contraindicated for use with alcohol, as the combination can lead to severe low blood pressure and fainting.
Advice From The Pharmacist
When taking Addyi, it is important to take it at bedtime to minimize the risk of side effects like dizziness, sleepiness, and low blood pressure. Do not drink alcohol while taking Addyi, as this can lead to dangerous drops in blood pressure and fainting. Be sure to inform your healthcare provider of all medications, supplements, and herbal products you are using, as many can interact with Addyi. If you do not see an improvement in your symptoms after 8 weeks of consistent use, consult your provider about whether to continue the medication.
Side Effects of Addyi
Common Side Effects
Common side effects of Addyi include dizziness, sleepiness, nausea, fatigue, and dry mouth. More serious side effects, though rare, include severe low blood pressure (especially if taken with alcohol or certain medications), fainting, and severe allergic reactions. If you experience symptoms such as fainting, extreme dizziness, or signs of an allergic reaction (e.g., swelling, rash, difficulty breathing), seek medical attention immediately.
Risks and Warnings of Addyi
The major risks associated with Addyi include the potential for severe low blood pressure and fainting, especially when combined with alcohol or certain medications. Because of these risks, it is crucial to avoid alcohol while taking Addyi and to discuss all medications with your healthcare provider to avoid dangerous interactions. Additionally, Addyi is only approved for use in premenopausal women with HSDD and should not be used for other types of sexual dysfunction or by postmenopausal women or men.
Interactions with Addyi
Common Drug Interactions
Addyi can interact with several medications, including:
- Strong CYP3A4 inhibitors (e.g., ketoconazole, certain HIV protease inhibitors): These can increase the levels of Addyi in the blood, leading to a higher risk of side effects.
- Alcohol: Can cause severe drops in blood pressure and fainting.
- Certain antifungals and antibiotics: These can also increase the risk of side effects.
Always inform your healthcare provider of all medications and supplements you are taking to avoid potential interactions.
Alternatives to Addyi
Alternative treatments for hypoactive sexual desire disorder (HSDD) in women may include:
- Lifestyle changes: Such as stress management and improving relationship dynamics.
- Counseling or therapy: To address psychological factors contributing to low sexual desire.
- Other medications: Such as bremelanotide (Vyleesi), an injectable medication also approved for HSDD in premenopausal women.
Your healthcare provider can help determine the best treatment option based on your specific needs and medical history.
