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Vyleesi
Vyleesi, the brand name for bremelanotide, is an injectable medication used to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. It works by activating melanocortin receptors in the brain, which are thought to play a role in sexual desire and arousal. Vyleesi is specifically indicated for women who have not yet reached menopause and who experience low sexual desire that causes distress or interpersonal difficulties, and is not caused by medical conditions, medications, or relationship issues.
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Frequently Asked Questions
How long does it take for Vyleesi to start working?
Vyleesi typically takes about 45 minutes to start working. It is recommended to administer the injection at least 45 minutes before anticipated sexual activity.
Can Vyleesi be used daily?
No, Vyleesi should not be used more than once per 24 hours or more than 8 times per month. Overuse can increase the risk of side effects such as nausea, elevated blood pressure, and skin darkening.
Does Vyleesi increase sexual desire immediately?
Vyleesi is intended to increase sexual desire in women with HSDD, but the response may vary. Some women may experience an increase in sexual desire within 45 minutes after taking the injection, while others may notice effects over time with continued use.
Can Vyleesi be used in postmenopausal women?
Vyleesi is only approved for use in premenopausal women with HSDD. It has not been studied or approved for use in postmenopausal women.
What should I do if I experience severe nausea with Vyleesi?
If you experience severe nausea, especially with the first dose, try taking Vyleesi with food. If nausea persists, consult your healthcare provider, who may recommend reducing the frequency of use or trying an anti-nausea medication.
Comprehensive Drug Guide
How Does Vyleesi Work?
Vyleesi works by activating melanocortin receptors in the brain, specifically MC1R and MC4R, which are involved in the regulation of sexual desire and arousal. By stimulating these receptors, Vyleesi helps increase sexual desire in women with HSDD. Unlike other treatments for sexual dysfunction, Vyleesi is taken on an as-needed basis rather than daily.
Common Dosages
- Vyleesi is available as an auto-injector containing 1.75 mg of bremelanotide per dose.
Typical Dosing
- The usual dose is 1.75 mg injected subcutaneously in the abdomen or thigh at least 45 minutes before anticipated sexual activity.
- No more than one dose should be taken within 24 hours, and no more than 8 doses per month should be used.
Typical Dosing
FDA Approved Indications
- Hypoactive sexual desire disorder (HSDD) in premenopausal women who experience low sexual desire that causes distress and is not due to a coexisting medical or psychiatric condition, relationship issues, or medication side effects.
Who Shouldn't Take Vyleesi?
- Uncontrolled hypertension (high blood pressure), as Vyleesi can cause a temporary increase in blood pressure.
- Known hypersensitivity to bremelanotide or any of its components.
Advice From The Pharmacist
- Administer Vyleesi at least 45 minutes before sexual activity for best results.
- Vyleesi is a subcutaneous injection, so it is important to inject it into the abdomen or thigh as directed. Avoid injecting into areas that are sore, bruised, or scarred.
- Store the auto-injector pens at room temperature and out of direct sunlight. Do not freeze.
- Do not exceed one dose in a 24-hour period or more than 8 doses per month, as this could increase the risk of side effects.
- Vyleesi can cause temporary nausea, especially with the first dose, which usually subsides over time with continued use.
Side Effects of Vyleesi
Common Side Effects
- Nausea (especially with the first dose)
- Flushing (warmth or redness of the skin)
- Headache
- Injection site reactions (such as redness or swelling)
- Fatigue
- Vomiting
Uncommon/Severe Side Effects
- Increased blood pressure: Vyleesi can cause temporary increases in blood pressure, so it should be used cautiously in patients with cardiovascular issues.
- Darkening of the skin (hyperpigmentation): Vyleesi can cause darkening of the skin, especially on the face, gums, and breasts, which may be long-lasting or permanent in some cases.
Risks and Warnings of Vyleesi
- Increased blood pressure: Vyleesi can cause transient increases in blood pressure that peak around 2 hours after administration. Patients with uncontrolled hypertension or cardiovascular conditions should use this medication with caution.
- Nausea: Nausea is the most common side effect and is especially likely with the first dose. Taking the medication with food may help reduce nausea, but if it is severe or persistent, consult your healthcare provider.
- Hyperpigmentation: In rare cases, Vyleesi can cause skin darkening (hyperpigmentation) on the face, gums, and breasts. This may be long-lasting or permanent in some individuals, particularly in those with darker skin tones.
- Use with alcohol: Drinking alcohol while using Vyleesi may increase the risk of side effects, such as nausea or headaches. It's advisable to limit alcohol consumption around the time of use.
Interactions with Vyleesi
Common Drug Interactions
- Blood pressure medications: Since Vyleesi can raise blood pressure, it may interact with medications used to lower blood pressure, such as ACE inhibitors or beta-blockers.
- Nausea medications: If nausea becomes problematic, your healthcare provider may recommend anti-nausea medications, but ensure they are compatible with Vyleesi.
- Medications affecting blood pressure: Medications that increase or decrease blood pressure should be carefully managed when using Vyleesi.
Alternatives to Vyleesi
- Addyi (flibanserin): An oral medication used to treat HSDD in premenopausal women. Unlike Vyleesi, Addyi is taken daily rather than on an as-needed basis.
- Hormonal therapy: For some women, hormone therapy (such as estrogen or testosterone) may be considered to help with low sexual desire, particularly in postmenopausal women or those with hormonal imbalances.
- Counseling and therapy: Psychological or sexual counseling may be recommended in cases where relationship issues or stress are contributing factors to low sexual desire.
