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Actiq

Actiq (fentanyl citrate) is a powerful opioid analgesic indicated for the management of breakthrough pain in cancer patients who are already receiving and are tolerant to opioid therapy. Actiq is delivered in a unique buccal formulation, allowing for rapid absorption of the medication through the mucous membranes in the mouth. This medication is designed to provide quick relief from severe pain that occurs in episodes, making it an essential option for patients who need immediate pain management.



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Frequently Asked Questions

How quickly does Actiq work?
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Actiq typically begins to relieve pain within 15 minutes after administration, making it suitable for managing sudden episodes of breakthrough pain.

Can I use Actiq if I'm not currently on opioid therapy?
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No, Actiq is indicated only for patients who are opioid-tolerant and currently receiving around-the-clock opioid therapy.

What should I do if I miss a dose of Actiq?
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If you miss a dose, do not take an extra dose. Wait until your next scheduled dose and take it as prescribed. Always maintain at least a 4-hour interval between doses.

Is Actiq safe for long-term use?
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Actiq is intended for use in managing breakthrough pain and is not typically used as a long-term pain management solution due to the risk of tolerance and dependence.

Can I take Actiq with other pain medications?
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Consult your healthcare provider before taking Actiq with other pain medications, as this may increase the risk of side effects, particularly respiratory depression.

Comprehensive Drug Guide

How Does Actiq Work?

Actiq works by binding to the mu-opioid receptors in the brain and spinal cord, which are involved in the modulation of pain perception. By activating these receptors, fentanyl reduces the sensation of pain and produces analgesia. The rapid absorption through the buccal mucosa leads to quick onset of action, making it effective for managing breakthrough pain episodes.



Common Dosages

  • Lozenges: 200 mcg, 400 mcg, 600 mcg, 800 mcg, 1200 mcg, and 1600 mcg of fentanyl

Typical Dosing

  • The recommended dose of Actiq is individualized based on the patient's previous opioid use and the severity of breakthrough pain. The starting dose is typically 200 mcg, with titration based on patient response and tolerability. Patients should wait at least 4 hours before using another dose.


Typical Dosing

FDA Approved Indications

  • Breakthrough pain in cancer patients who are opioid-tolerant and currently receiving around-the-clock opioid therapy.


Who Shouldn't Take Actiq?

  • Known hypersensitivity to fentanyl or any components of the formulation
  • Acute or severe bronchial asthma or chronic obstructive pulmonary disease (COPD) in an unmonitored setting
  • Severe respiratory depression


Advice From The Pharmacist

  • Use Actiq exactly as prescribed, ensuring that you are already receiving opioid therapy for chronic pain before using this medication.
  • Allow the lozenge to dissolve in the mouth without chewing or swallowing it for maximum effectiveness.
  • Be cautious of the potential for sedation and avoid driving or operating heavy machinery until you know how Actiq affects you.
  • Store Actiq at room temperature and keep it out of reach of children due to the risk of accidental overdose.


Side Effects of Actiq

Common Side Effects

  • Nausea
  • Drowsiness
  • Constipation
  • Dizziness


Uncommon/Severe Side Effects

  • Respiratory depression
  • Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing)


Risks and Warnings of Actiq

  • Respiratory Depression: Actiq can cause severe respiratory depression, especially in opioid-naive patients or when used in conjunction with other central nervous system depressants.
  • Risk of Misuse and Addiction: Due to its potent opioid nature, Actiq carries a risk of misuse, addiction, and overdose. Close monitoring by a healthcare provider is essential.
  • Withdrawal Symptoms: Patients who suddenly discontinue use may experience withdrawal symptoms; dosage adjustments should be made gradually under medical supervision.


Interactions with Actiq

Common Drug Interactions

  • CNS Depressants: Concomitant use of Actiq with other central nervous system depressants (such as benzodiazepines, alcohol, or muscle relaxants) can increase the risk of respiratory depression and sedation.
  • Inhibitors of CYP3A4: Medications that inhibit CYP3A4 enzymes may increase the effects of fentanyl, requiring careful monitoring and possible dose adjustments.


Alternatives to Actiq

  • Other opioids: Other strong opioids like morphine or oxycodone can be used for breakthrough pain management.
  • Non-opioid analgesics: For patients who are not opioid-tolerant, medications like acetaminophen or NSAIDs can be used for pain management.
  • Adjunctive therapies: Medications such as gabapentin or pregabalin may also be considered for pain management in conjunction with opioids.