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Accuretic
Accuretic is a combination medication containing quinapril, an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide, a thiazide diuretic (water pill). It is primarily used to treat high blood pressure (hypertension). Quinapril helps relax blood vessels by inhibiting an enzyme that causes blood vessels to constrict, while hydrochlorothiazide helps the body eliminate excess salt and water through urine. Together, these actions help lower blood pressure, reduce the risk of complications like stroke, heart attack, and kidney damage, and support better cardiovascular health.
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Frequently Asked Questions
What should I do if I miss a dose of Accuretic?
Take the missed dose as soon as you remember, but skip it if it’s almost time for your next dose. Do not double up on doses to make up for a missed one.
Can I take Accuretic with food?
Yes, Accuretic can be taken with or without food, but it’s important to take it consistently at the same time each day.
How long does it take for Accuretic to start lowering blood pressure?
Blood pressure may start to decrease within 1-2 weeks, but it may take 4-6 weeks to see the full effects.
Can Accuretic cause a persistent cough?
Yes, a dry cough is a common side effect of ACE inhibitors like quinapril. If the cough becomes bothersome, discuss alternatives with your healthcare provider.
Is Accuretic safe during pregnancy?
No, Accuretic should not be used during pregnancy, especially in the second and third trimesters, as it can harm the developing fetus.
Comprehensive Drug Guide
How Does Accuretic Work?
Accuretic works in two ways:
- Quinapril inhibits the activity of the angiotensin-converting enzyme (ACE), which normally causes blood vessels to constrict. By blocking this enzyme, quinapril helps relax and widen blood vessels, leading to lower blood pressure.
- Hydrochlorothiazide increases the amount of salt and water excreted by the kidneys, reducing fluid volume and helping to lower blood pressure further.
The combination of these two effects provides more comprehensive control of blood pressure than either medication alone.
Common Dosages
- Tablets: 10 mg quinapril / 12.5 mg hydrochlorothiazide, 20 mg quinapril / 12.5 mg hydrochlorothiazide, and 20 mg quinapril / 25 mg hydrochlorothiazide.
Typical Dosing
- The typical starting dose of Accuretic is 10 mg quinapril / 12.5 mg hydrochlorothiazide once daily. The dose may be adjusted based on blood pressure response, with a usual maintenance dose of 20 mg quinapril / 25 mg hydrochlorothiazide once daily.
Typical Dosing
FDA Approved Indications
- Treatment of hypertension (high blood pressure) in patients who require combination therapy.
Who Shouldn't Take Accuretic?
- Known hypersensitivity to quinapril, hydrochlorothiazide, or any components of the formulation.
- Angioedema related to previous ACE inhibitor therapy.
- Anuria (inability to produce urine).
- Pregnancy, due to the risk of fetal harm from ACE inhibitors.
Advice From The Pharmacist
Take Accuretic once daily, preferably in the morning to avoid frequent urination at night due to the diuretic component (hydrochlorothiazide). Drink plenty of water throughout the day to stay hydrated. Avoid potassium supplements or salt substitutes containing potassium unless advised by your healthcare provider, as ACE inhibitors like quinapril can increase potassium levels. Avoid alcohol, as it can lower blood pressure further and increase the risk of dizziness or fainting. Monitor your blood pressure regularly, and contact your healthcare provider if you experience symptoms like dizziness, lightheadedness, or swelling.
Side Effects of Accuretic
Common Side Effects
- Dizziness or lightheadedness, especially when standing up (orthostatic hypotension).
- Cough (a common side effect of ACE inhibitors).
- Increased urination (due to the diuretic component).
- Fatigue.
- Muscle cramps (due to electrolyte imbalances).
Uncommon/Severe Side Effects
- Angioedema (swelling of the face, lips, tongue, or throat), which can be life-threatening.
- Severe dehydration or electrolyte imbalances (symptoms include confusion, dry mouth, or muscle cramps).
- Kidney problems (decreased urination, swelling in legs or ankles).
- Liver problems (yellowing of the skin or eyes).
Risks and Warnings of Accuretic
- Accuretic can cause low blood pressure (hypotension), particularly in patients who are dehydrated or taking other blood pressure medications.
- If you experience dizziness or fainting, sit or lie down and contact your healthcare provider.
- Electrolyte imbalances (low potassium, sodium, or magnesium) can occur due to the diuretic component, so regular blood tests may be needed to monitor your levels.
- Kidney function should be monitored while taking Accuretic, especially in individuals with preexisting kidney issues. Pregnant women should avoid taking Accuretic, as it can cause harm to the developing fetus, particularly in the second and third trimesters.
Interactions with Accuretic
Common Drug Interactions
- Potassium supplements or potassium-sparing diuretics, which can increase the risk of high potassium levels.
- NSAIDs (such as ibuprofen), which can reduce the effectiveness of Accuretic and affect kidney function.
- Lithium, which may have its levels increased by hydrochlorothiazide, leading to toxicity.
- Other blood pressure medications, which may increase the risk of low blood pressure.
Alternatives to Accuretic
- Other ACE inhibitors (e.g., Lisinopril, Enalapril).
- Angiotensin II receptor blockers (ARBs) (e.g., Losartan, Valsartan).
- Other combination therapies (e.g., Losartan/Hydrochlorothiazide, Amlodipine/Benazepril).
