Browse Medications by Drug Class: Selective Estrogen Receptor Modulator (SERM)

Written by Amar Lunagaria
Pharm.D • NiHowdy Founder

Reviewed by James Wong
Pharm.D • NiHowdy Founder
Published Jan 15, 2025

What are Selective Estrogen Receptor Modulator (SERM)?
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List of drugs in Selective Estrogen Receptor Modulator (SERM)
Drug Name | More Information | NiHowdy Prices & Bitcoin Rebate |
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Evista | Evista Information | Evista Pricing |
Raloxifene HCl | Raloxifene HCl Information | Raloxifene HCl Pricing |
Brief history about Selective Estrogen Receptor Modulator (SERM)?
How do Selective Estrogen Receptor Modulator (SERM) work?
What are Selective Estrogen Receptor Modulator (SERM) used to treat?
Breast Cancer
SERMs like tamoxifen are widely used to treat and prevent hormone receptor-positive breast cancer. By blocking estrogen receptors in breast tissue, these medications reduce the growth of estrogen-dependent tumors. Tamoxifen is particularly effective in reducing recurrence and improving survival rates in pre- and postmenopausal women with breast cancer.
Osteoporosis
Raloxifene and other SERMs act as estrogen agonists in bone tissue, improving bone density and reducing the risk of fractures in postmenopausal women. They are especially useful for women who are at risk of osteoporosis but prefer to avoid traditional estrogen replacement therapy.
Menopausal Symptoms
Some SERMs, like bazedoxifene, are used in combination with estrogen to manage menopausal symptoms such as hot flashes and vaginal dryness. They provide the benefits of estrogen therapy while reducing the risk of endometrial hyperplasia, offering a balanced approach to symptom management.
Who should consider Selective Estrogen Receptor Modulator (SERM) medications?
Adults
Adults with hormone-sensitive breast cancer, osteoporosis, or severe menopausal symptoms are ideal candidates for SERMs. These medications provide targeted relief while minimizing risks associated with traditional hormone therapies. Healthcare providers tailor treatment to individual needs, balancing efficacy with potential side effects.
Children
SERMs are rarely used in pediatric populations but may be considered in specific cases, such as managing early-onset puberty or certain genetic conditions affecting bone density. Pediatric use requires careful dosing and close monitoring to ensure safety.
Seniors
Seniors benefit significantly from SERMs, particularly for osteoporosis prevention and breast cancer management. These medications improve bone density, reduce fracture risk, and provide cancer protection without the risks of systemic estrogen therapy. Healthcare providers adjust doses based on age-related changes in metabolism and overall health.
Are Selective Estrogen Receptor Modulator (SERM) safe?
Can I take Selective Estrogen Receptor Modulator (SERM) during pregnancy?
Are Selective Estrogen Receptor Modulator (SERM) safe to take while lactating?
Are Selective Estrogen Receptor Modulator (SERM) controlled substances?
Side effects of Selective Estrogen Receptor Modulator (SERM)?
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