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Zebutal

Zebutal, the generic version of Butalbital-Acetaminophen-Caffeine, is a combination medication for relieving tension headaches. Butalbital is a barbiturate that helps relax muscle contractions involved in tension headaches, Acetaminophen is a pain reliever (analgesic), and Caffeine helps increase the effects of acetaminophen while improving blood flow. Together, these ingredients relieve headache pain, reduce tension, and improve comfort for patients with tension-type headaches.

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Frequently Asked Questions

1. What is Zebutal used for?
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Zebutal is used primarily for the treatment of tension headaches.

2. Can I take Zebutal while pregnant?
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Zebutal should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Be sure to discuss this with your healthcare provider.

3. What are the common side effects of Zebutal?
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Common side effects of Zebutal include dizziness, drowsiness, and upset stomach.

4. Can I take Zebutal with other medications?
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It's important to share all medication history with your healthcare provider as Zebutal may interact with other medications.

5. What should I do if I miss a dose of Zebutal?
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If a dose is missed and it's close to the time for your next dose, skip the missed dose. If it's not near your next dose time, take it as soon as possible. Double dosing is not advised.

6. Can Zebutal be used for other types of headaches?
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Zebutal is primarily used for tension headaches. It's important to discuss with a healthcare professional if you're considering using it for other types of headaches.

Comprehensive Drug Guide

How Does Zebutal Work?

Zebutal works in three ways:

  • Butalbital helps relax muscle tension by acting on the central nervous system, making it easier for your body to handle stress and muscle contractions.
  • Acetaminophen works to reduce pain by blocking pain signals to the brain.
  • Caffeine improves blood flow and enhances the effectiveness of acetaminophen, making it work faster and more effectively to relieve pain.

Together, these ingredients target tension headaches by reducing muscle tightness, relieving pain, and boosting energy levels, helping patients feel more comfortable.

What is Zebutal Used For?

FDA-Approved Uses:

  • Zebutal is primarily used to relieve tension headaches in adults.

Off-Label Uses:

  • It may be occasionally prescribed for other types of headaches or mild pain management when patients cannot tolerate other medications.

Common Dosages

Zebutal is available in capsule form with the following strengths:

  • Butalbital 50 mg / Acetaminophen 325 mg / Caffeine 40 mg per capsule.

Typical Dosing

FDA Approved Indications

Treatment of Tension Headaches: Zebutal is prescribed to relieve tension headaches. It helps ease the pain and relaxes tight muscles in your head and neck.

Off-Label Uses

Migraine Relief: Some doctors may use Zebutal to treat migraine headaches, even though it's not officially approved for this purpose. This is less common because of potential side effects.

Other Types of Headaches: In rare cases, it might be used for other headache types, but only under a doctor's guidance.

Who Shouldn't Take Zebutal?

Zebutal should not be used in the following situations:

  • Allergy to butalbital, acetaminophen, caffeine, or other barbiturates
  • Porphyria is a genetic disorder affecting the skin or nervous system
  • Severe liver or kidney disease, as acetaminophen can worsen liver function
  • History of drug or alcohol abuse due to the potential for dependence

Advice From The Pharmacist

Take Zebutal with food or milk to prevent stomach upset.

Avoid alcohol while taking Zebutal, as it can increase the risk of liver damage and enhance the sedative effects of butalbital.

Do not drive or operate machinery until you know how Zebutal affects you, as it may cause drowsiness.

Limit caffeine intake from other sources, like coffee or soda, as this medication already contains caffeine.

Side Effects of Zebutal

Common Side Effects

  • Drowsiness
  • Dizziness
  • Lightheadedness
  • Upset stomach
  • Nausea

Uncommon/Severe Side Effects

  • Liver damage (especially with long-term use or overdose of acetaminophen)
  • Signs of an allergic reaction (rash, itching, swelling, difficulty breathing)
  • Confusion or mood changes
  • Trouble breathing or a slow heartbeat

Risks and Warnings of Zebutal

Risk of Dependence: Butalbital is habit-forming, especially if used for extended periods. Patients should not take more than the prescribed dose or use Zebutal for longer than recommended.

Liver Toxicity: Acetaminophen can cause serious liver damage, especially if combined with alcohol or taken in high doses. Do not exceed the daily recommended limit of acetaminophen.

Overuse Headaches: Using Zebutal too frequently can lead to rebound headaches, where the headache worsens after the medication wears off.

Interactions with Zebutal

Common Drug Interactions

Opioids and sedatives (e.g., morphine, benzodiazepines) – Increase the risk of drowsiness, respiratory depression, and sedation.

Alcohol – Increases the risk of liver damage and enhances the sedative effects of butalbital.

Anticoagulants (e.g., warfarin) – May increase the risk of bleeding.

Alternatives to Zebutal

Acetaminophen or Ibuprofen: For those who need pain relief without the risk of dependence on butalbital.

Aspirin-Caffeine Combination (Excedrin): Over-the-counter options for tension headaches without butalbital.

Sumatriptan (Imitrex): If headaches are related to migraines rather than tension headaches.

Topiramate (Topamax): An alternative for chronic headaches or migraines, particularly for prevention.