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Xyosted
Xyosted (testosterone enanthate) is an injectable form of testosterone used to treat men with low testosterone levels or hypogonadism. Testosterone is a hormone essential for male development, sexual function, and maintaining muscle mass, bone density, and red blood cell production. Xyosted is a subcutaneous injection that provides a once-weekly dose of testosterone to restore normal levels in men with testosterone deficiency.
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Frequently Asked Questions
How quickly does Xyosted start working?
Xyosted typically begins to restore testosterone levels within 1-2 weeks after the first injection, but it may take several weeks to feel the full effects of the treatment.
Can I self-administer Xyosted?
Yes, Xyosted is designed to be self-administered. After receiving proper training from your healthcare provider, you can inject it subcutaneously at home once a week.
What should I do if I miss a dose of Xyosted?
If you miss a dose, administer it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can Xyosted be used by women?
No, Xyosted is not approved for use in women. Testosterone therapy is intended for men with low testosterone levels and should not be used by women or children.
Does Xyosted require regular monitoring?
Yes, regular blood tests are necessary to monitor testosterone levels, red blood cell count, and liver function to ensure the treatment is effective and safe.
Comprehensive Drug Guide
How Does Xyosted Work?
Xyosted works by delivering testosterone enanthate into the bloodstream through subcutaneous injection, which gradually releases testosterone over the week. Testosterone is essential for many bodily functions, including the development of male secondary sexual characteristics, muscle mass, bone density, and the production of red blood cells. By restoring normal testosterone levels, Xyosted helps alleviate symptoms of hypogonadism such as fatigue, decreased libido, and loss of muscle mass.
Common Dosages
- 50 mg, 75 mg, and 100 mg pre-filled autoinjectors
Typical Dosing
- For testosterone replacement therapy: The recommended starting dose of Xyosted is 75 mg administered subcutaneously once weekly. The dose can be adjusted based on blood testosterone levels and individual response.
Typical Dosing
FDA Approved Indications
- Primary hypogonadism (congenital or acquired)
- Hypogonadotropic hypogonadism (congenital or acquired)
Who Shouldn't Take Xyosted?
- Breast cancer or prostate cancer
- Known hypersensitivity to testosterone or any component of the formulation
- Severe heart, liver, or kidney disease
- Pregnant or breastfeeding women (testosterone can cause harm to an unborn baby)
Advice From The Pharmacist
- Xyosted is administered once weekly via a pre-filled autoinjector. It should be injected subcutaneously into the abdomen, avoiding the navel area. Rotate injection sites each week to avoid skin irritation.
- Blood testosterone levels should be regularly monitored during treatment to ensure the correct dosage and avoid adverse effects.
- Do not use Xyosted if the solution appears discolored or cloudy.
- Xyosted is for men only and should not be used by women or children.
- Store Xyosted at room temperature and avoid exposure to direct sunlight or freezing.
Side Effects of Xyosted
Common Side Effects
- Skin irritation or redness at the injection site
- Headache
- Increased red blood cell count (polycythemia)
- Mood swings or changes in libido
- Acne
Uncommon/Severe Side Effects
- High blood pressure
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Worsening of prostate conditions (such as benign prostatic hyperplasia or prostate cancer)
- Enlarged breasts (gynecomastia) in men
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Xyosted
- Cardiovascular Risks: Xyosted can increase the risk of heart attack, stroke, or death in men, particularly those with pre-existing heart conditions. Regular monitoring of blood pressure and cholesterol levels is recommended.
- Prostate Cancer: Testosterone therapy may stimulate the growth of prostate cancer. Men with prostate cancer or a history of prostate issues should not use Xyosted.
- Polycythemia: Xyosted can increase red blood cell production, leading to a higher risk of blood clots. Blood tests to monitor red blood cell count are necessary during treatment.
- Abuse Potential: Testosterone products have the potential for misuse, particularly for performance enhancement in athletes or bodybuilders. Misuse of testosterone can lead to serious side effects, including heart disease and liver damage.
Interactions with Xyosted
Common Drug Interactions
- Anticoagulants (e.g., warfarin): Xyosted can enhance the effects of blood thinners, increasing the risk of bleeding.
- Corticosteroids: Combining Xyosted with corticosteroids can increase the risk of fluid retention and swelling.
- Diabetes medications: Testosterone may affect blood sugar levels, so dosage adjustments of diabetes medications may be necessary.
- Cyclosporine: Xyosted may increase cyclosporine levels, increasing the risk of kidney damage.
Alternatives to Xyosted
- Testosterone cypionate: An injectable testosterone replacement therapy administered intramuscularly, typically every 1-2 weeks.
- Testosterone gel (AndroGel): A topical testosterone replacement therapy applied daily to the skin.
- Testosterone patches: Applied daily to the skin to provide steady testosterone levels throughout the day.
- Clomiphene citrate: A non-testosterone option that stimulates the body’s own testosterone production, often used for men with low testosterone who are trying to preserve fertility.
