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Xtampza ER
Xtampza ER (oxycodone extended-release) is an opioid analgesic used to manage severe pain that requires long-term, around-the-clock treatment and cannot be controlled with other pain medications. Xtampza ER contains oxycodone, a potent opioid, and is designed to provide extended pain relief throughout the day. The medication is formulated to be abuse-deterrent, making it more difficult to misuse by crushing, snorting, or injecting.
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Frequently Asked Questions
How long does Xtampza ER take to start working?
Xtampza ER typically begins to relieve pain within 1-2 hours after taking a dose, with the extended-release formulation providing relief for up to 12 hours.
Can I stop taking Xtampza ER suddenly?
No, do not stop taking Xtampza ER suddenly without consulting your healthcare provider. Abrupt discontinuation can lead to withdrawal symptoms such as anxiety, sweating, and agitation. Your doctor will provide a tapering schedule if you need to stop taking the medication.
Can I drink alcohol while taking Xtampza ER?
No, you should avoid alcohol while taking Xtampza ER. Combining alcohol with this medication can increase the risk of severe side effects like sedation, respiratory depression, and death.
What should I do if I miss a dose of Xtampza ER?
If you miss a dose, take it as soon as you remember, but skip the missed dose if it is close to your next scheduled dose. Do not take an extra dose to make up for the missed one.
Is Xtampza ER safe for long-term use?
Xtampza ER can be used for long-term pain management in patients who need continuous opioid therapy. However, it carries risks of dependence, tolerance, and potential side effects, so it should be used with caution and under regular medical supervision.
Comprehensive Drug Guide
How Does Xtampza ER Work?
Xtampza ER works by binding to mu-opioid receptors in the brain and spinal cord, altering the perception of pain and providing significant relief for moderate to severe pain. The extended-release formulation provides long-lasting pain control, typically over a 12-hour period, reducing the need for frequent dosing.
What is Xtampza ER Used For?
Common Dosages
- 9 mg, 13.5 mg, 18 mg, 27 mg, and 36 mg extended-release capsules.
Typical Dosing
- For chronic pain: The starting dose for opioid-naive patients is typically 9 mg every 12 hours, with dose adjustments made based on individual response and pain control. The maximum daily dose should be determined by a healthcare provider, but the lowest effective dose should be used to minimize the risk of side effects and dependence.
Typical Dosing
FDA Approved Indications
- Chronic severe pain requiring long-term, around-the-clock opioid therapy when other pain relief treatments are inadequate.
Off-Label Uses
Who Shouldn't Take Xtampza ER?
- Severe respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting
- Paralytic ileus (bowel obstruction)
- Known hypersensitivity to oxycodone or any component of the formulation
Advice From The Pharmacist
- Xtampza ER capsules should be taken every 12 hours, with or without food. If you cannot swallow the capsule whole, you may sprinkle the contents on soft foods like applesauce, but do not crush or chew the contents.
- Do not take more than the prescribed dose, as Xtampza ER can cause life-threatening respiratory depression or overdose.
- Avoid alcohol and other central nervous system depressants while taking Xtampza ER, as these can increase the risk of dangerous side effects such as sedation, respiratory depression, or death.
- Regular monitoring by your healthcare provider is required to adjust the dosage and manage side effects.
- Store Xtampza ER in a safe place to prevent misuse, abuse, or accidental ingestion, especially by children.
Side Effects of Xtampza ER
Common Side Effects
- Drowsiness
- Constipation
- Nausea
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Respiratory depression (slow or shallow breathing)
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Low blood pressure
- Addiction, abuse, and misuse
- Overdose (characterized by extreme drowsiness, pinpoint pupils, or inability to wake up)
Risks and Warnings of Xtampza ER
- Respiratory Depression: Xtampza ER can cause life-threatening respiratory depression, especially when starting treatment or after a dose increase. Patients should be closely monitored for breathing problems.
- Abuse and Dependence: Xtampza ER has a high potential for abuse, and prolonged use can lead to physical and psychological dependence. It should be used only when necessary and under close supervision by a healthcare provider.
- Accidental Overdose: Taking Xtampza ER in larger amounts or combining it with other CNS depressants like alcohol, benzodiazepines, or other opioids can result in overdose and death.
- Withdrawal Symptoms: If Xtampza ER is discontinued suddenly, withdrawal symptoms such as restlessness, anxiety, sweating, and muscle aches can occur. Tapering off the medication under medical supervision is advised.
Interactions with Xtampza ER
Common Drug Interactions
- CNS depressants (e.g., alcohol, benzodiazepines, sedatives): Combining Xtampza ER with other CNS depressants increases the risk of severe sedation, respiratory depression, coma, or death.
- MAO inhibitors: Using Xtampza ER with monoamine oxidase inhibitors (MAOIs) can lead to severe, life-threatening reactions. Xtampza ER should not be used within 14 days of taking an MAOI.
- Cytochrome P450 inhibitors/inducers: Drugs that inhibit or induce certain liver enzymes (CYP3A4 and CYP2D6) can affect how Xtampza ER is metabolized, potentially increasing the risk of side effects or reducing its efficacy.
Alternatives to Xtampza ER
- OxyContin (oxycodone extended-release): A similar long-acting opioid analgesic used for managing severe chronic pain.
- Morphine ER: An extended-release formulation of morphine used for long-term pain relief in patients requiring continuous opioid therapy.
- Fentanyl patches: A transdermal system used for continuous, long-term pain relief in patients who are opioid-tolerant.
- Non-opioid pain relievers (e.g., acetaminophen, NSAIDs): May be suitable for patients with less severe pain or those who wish to avoid opioids.
