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Xofluza (80 MG Dose)
Xofluza (generic name: baloxavir marboxil) is an antiviral medication used to treat acute, uncomplicated influenza (the flu) in patients who have had symptoms for no more than 48 hours. It is effective against both influenza A and influenza B viruses. Xofluza can help reduce the severity of flu symptoms and shorten the duration of illness by inhibiting viral replication in the body.
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Frequently Asked Questions
How quickly does Xofluza start working?
Xofluza begins to work shortly after taking the single dose, and patients may notice a reduction in symptoms within 24 to 48 hours.
Can Xofluza be used to prevent the flu?
Yes, Xofluza is approved for post-exposure prophylaxis, meaning it can be used to help prevent flu in individuals who have been exposed to someone with the flu, provided it is taken within 48 hours of exposure.
What should I do if I miss a dose of Xofluza?
Xofluza is typically taken as a single dose. If you miss the dose or forget to take it, take it as soon as possible within 48 hours of the onset of flu symptoms.
Can I take Xofluza with other medications?
Xofluza may interact with calcium, magnesium, iron, and zinc, so avoid taking it with products that contain these minerals. Otherwise, consult your healthcare provider about any other medications you are taking.
Is Xofluza safe for long-term use?
Xofluza is intended for short-term use to treat or prevent flu. It is not recommended for long-term use, as this may lead to viral resistance. Always follow your healthcare provider’s instructions.
Comprehensive Drug Guide
How Does Xofluza (80 MG Dose) Work?
Baloxavir marboxil, the active ingredient in Xofluza, works by inhibiting the viral cap-dependent endonuclease, an enzyme necessary for viral replication. This prevents the flu virus from multiplying and spreading in the body, helping to reduce the duration and severity of flu symptoms.
Common Dosages
- 80 mg tablets
Typical Dosing
- Adults and adolescents (12 years and older): The typical dose of Xofluza is based on body weight:
- 40 mg dose for patients weighing 40 kg to less than 80 kg.
- 80 mg dose for patients weighing 80 kg or more.
- Xofluza is taken as a single dose with or without food. For the 80 mg dose, patients typically take two 40 mg tablets at the same time.
Typical Dosing
FDA Approved Indications
- Treatment of acute, uncomplicated influenza in patients aged 12 years and older who have had flu symptoms for less than 48 hours.
- Post-exposure prophylaxis (prevention) of influenza after contact with someone who has the flu.
Who Shouldn't Take Xofluza (80 MG Dose)?
- Known hypersensitivity to baloxavir marboxil or any component of the formulation.
- Severe allergic reactions to previous flu medications (check with a healthcare provider if unsure).
Advice From The Pharmacist
- Take Xofluza as soon as possible after flu symptoms appear (within 48 hours) for the best results.
- Do not take with dairy products, antacids, or supplements containing calcium, iron, magnesium, or zinc, as these can reduce the absorption of Xofluza.
- Complete the full dose as prescribed, even if symptoms start to improve.
- Stay hydrated and continue managing symptoms with other treatments, such as rest and over-the-counter medications for fever or pain.
Side Effects of Xofluza (80 MG Dose)
Common Side Effects
- Diarrhea
- Headache
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Anaphylaxis (very rare)
Risks and Warnings of Xofluza (80 MG Dose)
- Delayed Treatment: Xofluza is most effective when taken within 48 hours of the onset of flu symptoms. Taking it later may reduce its effectiveness.
- Resistance: Overuse of antiviral medications like Xofluza can lead to viral resistance. It should only be used when prescribed and not as a routine preventive measure unless directed by a healthcare provider.
Interactions with Xofluza (80 MG Dose)
Common Drug Interactions
- Calcium-containing products: Avoid taking Xofluza with dairy products, calcium-fortified juices, or supplements containing calcium, iron, magnesium, or zinc, as these can interfere with the absorption of Xofluza and reduce its effectiveness.
- Other antivirals: Consult your healthcare provider before combining Xofluza with other antiviral medications.
Alternatives to Xofluza (80 MG Dose)
- Oseltamivir (Tamiflu): Another antiviral used to treat or prevent influenza, taken as a five-day course.
- Zanamivir (Relenza): An inhaled antiviral used for flu treatment and prevention.
- Peramivir (Rapivab): An intravenous antiviral for treating acute uncomplicated influenza.
