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Xofluza (40 MG Dose)
Xofluza (generic name: baloxavir marboxil) is an antiviral medication used to treat the flu (influenza) in people 12 years of age and older who have had symptoms for no more than 48 hours. It is also used to prevent the flu in people who have been exposed to the virus. Xofluza is a cap-dependent endonuclease inhibitor, which works by inhibiting the replication of the flu virus, helping to reduce the duration of symptoms and limit the spread of the virus.
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Frequently Asked Questions
How quickly does Xofluza work?
Xofluza begins working within 24 hours to inhibit viral replication. It can shorten the duration of flu symptoms by 1 to 2 days if taken early.
Can Xofluza prevent the flu?
Yes, Xofluza can be taken to prevent the flu if you have been exposed to the virus. A single dose of Xofluza may reduce the likelihood of developing flu symptoms after exposure.
What should I do if I miss the window to take Xofluza within 48 hours of symptoms?
Xofluza is most effective when taken within 48 hours of symptom onset. If more than 48 hours have passed, consult your healthcare provider for advice on how to manage your symptoms.
Can I take Xofluza with other flu medications?
Xofluza should not be taken with other antiviral medications for the flu unless directed by your healthcare provider.
Is Xofluza safe for children?
Xofluza is approved for use in children aged 12 and older. For children under 12, consult a healthcare provider for appropriate flu treatments.
Comprehensive Drug Guide
How Does Xofluza (40 MG Dose) Work?
Xofluza works by inhibiting the cap-dependent endonuclease enzyme, which the influenza virus uses to replicate. By blocking this enzyme, Xofluza prevents the virus from multiplying in the body, reducing the severity and duration of flu symptoms and helping prevent the virus from spreading to others.
Common Dosages
- 40 mg tablet for patients who weigh between 40 kg and less than 80 kg
- 80 mg tablet for patients who weigh 80 kg or more
Typical Dosing
- Treatment of flu: The typical dose for patients weighing 40 to less than 80 kg is 40 mg (one tablet) taken as a single dose. For patients weighing 80 kg or more, the dose is 80 mg.
- Prevention of flu: A single dose of 40 mg is taken if the patient weighs 40 to less than 80 kg.
Typical Dosing
FDA Approved Indications
- Treatment of acute, uncomplicated influenza in patients aged 12 and older who have been symptomatic for no more than 48 hours.
- Post-exposure prophylaxis to prevent the flu in patients who have been exposed to the virus.
Who Shouldn't Take Xofluza (40 MG Dose)?
- Known hypersensitivity to baloxavir marboxil or any of the ingredients in Xofluza.
- A history of serious allergic reactions to the medication.
Advice From The Pharmacist
- Take Xofluza as soon as possible after flu symptoms begin, ideally within 48 hours. It is most effective when taken early.
- Xofluza can be taken with or without food, but avoid taking it with dairy products, calcium-fortified beverages, or antacids that contain calcium, magnesium, iron, or zinc, as these can interfere with absorption.
- Xofluza is a single-dose medication, so there is no need to continue taking it after the initial dose.
Side Effects of Xofluza (40 MG Dose)
Common Side Effects
- Diarrhea
- Nausea
- Headache
- Cough
Uncommon/Severe Side Effects
- Allergic reactions such as rash, itching, swelling, or difficulty breathing
Risks and Warnings of Xofluza (40 MG Dose)
- Allergic Reactions: Though rare, some individuals may experience serious allergic reactions such as anaphylaxis. Discontinue use and seek medical attention if symptoms like rash, swelling, or breathing difficulties occur.
- Secondary Infections: Xofluza does not treat bacterial infections. If flu symptoms persist or worsen, contact your healthcare provider to rule out a secondary bacterial infection.
Interactions with Xofluza (40 MG Dose)
Common Drug Interactions
- Antacids or supplements: Avoid taking Xofluza with products containing calcium, magnesium, iron, or zinc. These minerals can interfere with the absorption of the medication and reduce its effectiveness.
- Live flu vaccines: Xofluza may reduce the efficacy of live flu vaccines. Consult your healthcare provider if you have recently received or plan to receive a live vaccine.
Alternatives to Xofluza (40 MG Dose)
- Tamiflu (oseltamivir): Another antiviral used to treat and prevent the flu, typically taken over the course of 5 days.
- Relenza (zanamivir): An inhaled antiviral used for flu treatment and prevention.
- Rapivab (peramivir): An intravenous antiviral treatment for the flu, typically used in hospital settings.
- Flu vaccine: Annual vaccination is recommended to prevent flu infection and reduce the severity of symptoms.
