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Wixela Inhub
Wixela Inhub is a combination inhaler containing fluticasone propionate (a corticosteroid) and salmeterol (a long-acting beta-agonist or LABA). It is used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Fluticasone helps reduce inflammation in the airways, while salmeterol works by relaxing the muscles around the airways, improving airflow and reducing symptoms like shortness of breath, wheezing, and coughing. Wixela Inhub is prescribed to help manage symptoms and prevent exacerbations in patients with chronic respiratory conditions.
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Frequently Asked Questions
How long does it take for Wixela Inhub to start working?
Wixela Inhub is designed for long-term control and maintenance of asthma and COPD. It may take 1 to 2 weeks to notice significant improvements in symptoms.
Can Wixela Inhub be used as a rescue inhaler?
No, Wixela Inhub is not a rescue inhaler and should not be used to treat sudden asthma or COPD attacks. You should always have a fast-acting inhaler, such as albuterol, available for emergencies.
How should I store my Wixela Inhub inhaler?
Store Wixela Inhub at room temperature and keep it dry. Do not store it in a humid environment, such as a bathroom, and avoid exposing it to extreme temperatures.
Can I stop using Wixela Inhub if my symptoms improve?
No, Wixela Inhub should be used regularly, even if you feel well. Stopping the medication without consulting your healthcare provider may cause your symptoms to worsen.
What should I do if I miss a dose of Wixela Inhub?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take extra doses to make up for the missed one.
Comprehensive Drug Guide
How Does Wixela Inhub Work?
Wixela Inhub combines the anti-inflammatory effects of fluticasone, which reduces swelling and irritation in the airways, with the bronchodilating effects of salmeterol, which relaxes the smooth muscles in the airways, helping to keep them open. This combination improves lung function, reduces the frequency of asthma attacks, and helps manage COPD symptoms by preventing airway constriction.
Common Dosages
- 100 mcg fluticasone / 50 mcg salmeterol
- 250 mcg fluticasone / 50 mcg salmeterol
- 500 mcg fluticasone / 50 mcg salmeterol
Typical Dosing
- For asthma, the typical starting dose is one inhalation twice daily (approximately 12 hours apart). The dose may be adjusted based on the severity of symptoms and the patient’s response.
- For COPD, the recommended dose is one inhalation twice daily, typically using the 250 mcg/50 mcg or 500 mcg/50 mcg strength.
Typical Dosing
FDA Approved Indications
- Maintenance treatment of asthma in patients aged 4 years and older.
- Maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Who Shouldn't Take Wixela Inhub?
- Severe hypersensitivity to fluticasone, salmeterol, or any other ingredients in the inhaler.
- Primary treatment of acute asthma symptoms or acute exacerbations of COPD.
- Use of long-acting beta-agonists (LABAs) without inhaled corticosteroids for asthma management due to the increased risk of asthma-related death.
Advice From The Pharmacist
- Use Wixela Inhub regularly, even when you feel well, to help prevent asthma or COPD symptoms. It is not a rescue inhaler and should not be used to relieve sudden breathing problems.
- Rinse your mouth with water after each use to prevent oral thrush (a fungal infection in the mouth), which can occur due to the inhaled corticosteroid.
- Keep track of your inhaler’s dose counter to know when it is running low, and always have a backup inhaler on hand.
Side Effects of Wixela Inhub
Common Side Effects
- Headache
- Throat irritation or hoarseness
- Cough
- Muscle or bone pain
Uncommon/Severe Side Effects
- Increased risk of pneumonia in COPD patients
- Oral thrush (candidiasis) in the mouth or throat
- Adrenal suppression, which may cause fatigue, weakness, and low blood pressure
- Paradoxical bronchospasm, a rare worsening of breathing after inhalation
Risks and Warnings of Wixela Inhub
- Asthma-Related Death: Long-acting beta-agonists (LABAs) like salmeterol have been associated with an increased risk of asthma-related death when used without an inhaled corticosteroid. Wixela Inhub contains both medications to mitigate this risk, but it should still be used under medical supervision.
- Infection Risk: Corticosteroids like fluticasone can weaken the immune system, making patients more susceptible to infections such as pneumonia or oral thrush. Patients with COPD are particularly at risk for pneumonia.
- Bone Health: Long-term use of inhaled corticosteroids may reduce bone density. Patients at risk of osteoporosis should be monitored regularly.
Interactions with Wixela Inhub
Common Drug Interactions
- Beta-blockers: These medications can reduce the effectiveness of salmeterol and may increase the risk of bronchospasm in asthma or COPD patients.
- Diuretics: Medications that reduce potassium levels (e.g., furosemide) may increase the risk of low potassium (hypokalemia) when used with salmeterol.
- CYP3A4 inhibitors: Drugs like ketoconazole or ritonavir can increase the levels of fluticasone or salmeterol, increasing the risk of side effects such as adrenal suppression or heart problems.
Alternatives to Wixela Inhub
- Advair Diskus (fluticasone/salmeterol): A similar combination inhaler containing the same active ingredients as Wixela Inhub.
- Symbicort (budesonide/formoterol): A combination of an inhaled corticosteroid and long-acting beta-agonist used for asthma and COPD management.
- Breo Ellipta (fluticasone/vilanterol): Another combination inhaler used for the maintenance treatment of asthma and COPD.
- Trelegy Ellipta: A combination inhaler that includes a corticosteroid, LABA, and long-acting muscarinic antagonist (LAMA) for COPD management.
