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Advair Diskus
Advair Diskus is a combination inhaler containing fluticasone propionate (a corticosteroid) and salmeterol (a long-acting beta-2 agonist). It is used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Fluticasone helps reduce inflammation in the airways, while salmeterol relaxes the muscles around the airways to improve breathing. Advair Diskus is intended for regular use to manage chronic symptoms and prevent asthma attacks or COPD exacerbations; it is not a rescue inhaler for acute symptoms.
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Frequently Asked Questions
How long does it take for Advair Diskus to start working?
While Advair Diskus can begin improving breathing within 30 minutes, it is primarily a maintenance inhaler. It may take 1 to 2 weeks of regular use to see the full benefit in preventing asthma or COPD symptoms.
Can I use Advair Diskus during an asthma attack?
No, Advair Diskus is not a rescue inhaler. You should use a short-acting beta-2 agonist, such as albuterol, for quick relief during an asthma attack.
How should I store Advair Diskus?
Store Advair Diskus at room temperature, away from moisture and heat. Do not wash the inhaler or expose it to water.
What should I do if I miss a dose of Advair Diskus?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your normal schedule. Do not double up on doses.
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your normal schedule. Do not double up on doses.
Yes, Advair Diskus is approved for use in children 4 years and older for the treatment of asthma. The dose will depend on the child's specific needs and should be prescribed by a healthcare provider.
Comprehensive Drug Guide
How Does Advair Diskus Work?
- Fluticasone propionate: A corticosteroid that reduces inflammation in the lungs, helping to prevent asthma attacks and reduce COPD symptoms.
- Salmeterol: A long-acting beta-2 adrenergic agonist that works by relaxing the smooth muscles around the airways, keeping them open and improving airflow for up to 12 hours.
Common Dosages
- 100 mcg / 50 mcg
- 250 mcg / 50 mcg
- 500 mcg / 50 mcg
- The appropriate strength and dosing frequency depend on the severity of the patient’s condition and should be determined by a healthcare provider.
Typical Dosing
- For asthma: Typically, patients are advised to inhale one puff twice daily, approximately 12 hours apart, using the strength prescribed by their doctor.
- For COPD: The usual dose is one puff of the 250 mcg / 50 mcg inhaler twice daily, 12 hours apart.
Typical Dosing
FDA Approved Indications
- Asthma in patients aged 4 years and older who require both a corticosteroid and long-acting bronchodilator.
- Chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, to reduce exacerbations and improve airflow.
Who Shouldn't Take Advair Diskus?
- A known hypersensitivity to fluticasone, salmeterol, or any other ingredients in the formulation.
- Acute episodes of asthma or COPD where a rescue inhaler is required (such as during a sudden asthma attack).
Advice From The Pharmacist
- Rinse your mouth after using Advair Diskus to reduce the risk of oral thrush (a fungal infection in the mouth).
- Always use Advair Diskus regularly, even when you feel well, to prevent asthma or COPD symptoms from worsening.
- Do not use Advair Diskus to treat acute asthma attacks. Always have a rescue inhaler like albuterol on hand for sudden symptoms.
- Store the inhaler in a dry place at room temperature. Keep it away from moisture or extreme temperatures.
- Be sure to use the Diskus correctly by fully inhaling the dose. If you have trouble, ask your healthcare provider for a demonstration.
Side Effects of Advair Diskus
Common Side Effects
- Hoarseness or sore throat
- Headache
- Nausea
- Cough
- Oral thrush (fungal infection in the mouth)
Uncommon/Severe Side Effects
- Increased risk of pneumonia in patients with COPD
- Adrenal suppression (when the body’s natural steroid production is reduced)
- Increased heart rate or palpitations
- Worsening of asthma symptoms if used improperly
Risks and Warnings of Advair Diskus
- Asthma-related deaths: Long-acting beta-agonists (such as salmeterol) have been associated with an increased risk of asthma-related deaths. Advair Diskus should only be used when other asthma medications are not sufficient to control symptoms.
- Pneumonia risk in COPD: Patients with COPD using Advair Diskus may have an increased risk of developing pneumonia. Patients should be monitored closely for signs of respiratory infections.
- Oral fungal infections: Inhaled corticosteroids can cause oral thrush. Rinse your mouth after each use to minimize this risk.
- Adrenal insufficiency: Long-term use of high doses may suppress the adrenal glands, reducing their ability to produce natural steroids.
Interactions with Advair Diskus
Common Drug Interactions
- Beta-blockers: May reduce the effectiveness of salmeterol, leading to uncontrolled asthma or COPD symptoms.
- Diuretics: Concurrent use may increase the risk of low potassium levels (hypokalemia).
- CYP3A4 inhibitors (such as ketoconazole or ritonavir): May increase the concentration of fluticasone and salmeterol in the blood, potentially increasing the risk of side effects.
- Other long-acting beta-agonists: Using more than one long-acting beta-agonist can increase the risk of serious side effects, including heart problems.
Alternatives to Advair Diskus
- Symbicort (budesonide/formoterol): A combination inhaler with a corticosteroid and long-acting beta-2 agonist for asthma and COPD.
- Breo Ellipta (fluticasone/vilanterol): Another combination inhaler used for both asthma and COPD that is taken once daily.
- Dulera (mometasone/formoterol): A combination inhaler for asthma.
- Pulmicort (budesonide): An inhaled corticosteroid often used as a controller medication for asthma.
- Serevent Diskus (salmeterol): A long-acting bronchodilator used to manage asthma or COPD when combined with an inhaled corticosteroid.