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Vyfemla
Vyfemla is an oral contraceptive containing norethindrone and ethinyl estradiol, used to prevent pregnancy. It works by inhibiting ovulation (the release of an egg), thickening the cervical mucus to prevent sperm from reaching the egg, and altering the uterine lining to make implantation less likely. Vyfemla is also used to regulate menstrual cycles, reduce menstrual pain, and treat acne in women who seek contraception.
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Frequently Asked Questions
How effective is Vyfemla in preventing pregnancy?
Vyfemla is over 99% effective when taken as directed. However, missing pills or taking them inconsistently may reduce its effectiveness.
What should I do if I miss a dose of Vyfemla?
If you miss one pill, take it as soon as you remember. If you miss two or more pills, follow the package instructions and use backup contraception for 7 days.
Can Vyfemla cause weight gain?
Weight changes are possible with Vyfemla, though most weight gain is typically minor and may result from fluid retention or hormonal fluctuations.
Can I take Vyfemla if I smoke?
Smoking while taking Vyfemla is not recommended, especially in women over 35, due to the increased risk of serious cardiovascular events.
Does Vyfemla help with acne?
Yes, Vyfemla can help reduce acne in women who are also seeking contraceptive benefits by regulating hormones that contribute to acne.
Comprehensive Drug Guide
How Does Vyfemla Work?
Vyfemla works by preventing ovulation through the action of norethindrone, a synthetic progestin, and ethinyl estradiol, a synthetic estrogen. Together, these hormones suppress the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are necessary for ovulation. Vyfemla also thickens the cervical mucus, making it difficult for sperm to enter the uterus, and alters the uterine lining, preventing the implantation of a fertilized egg.
Common Dosages
- 21 active tablets with 0.4 mg norethindrone and 0.035 mg ethinyl estradiol
- 7 placebo tablets without active hormones
Typical Dosing
- Take one active pill daily for 21 days, followed by one placebo pill daily for 7 days. During the placebo week, withdrawal bleeding typically occurs, similar to a menstrual period.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy
- Regulation of menstrual cycles
- Treatment of hormonal imbalances, including acne and heavy periods
Who Shouldn't Take Vyfemla?
- A history of blood clots, stroke, or heart attack
- Known or suspected breast cancer or other estrogen-sensitive cancers
- Liver disease or liver tumors
- Uncontrolled high blood pressure
- Known hypersensitivity to norethindrone, ethinyl estradiol, or any other components of the medication
Advice From The Pharmacist
- Take Vyfemla at the same time every day for maximum effectiveness. Missing doses can increase the risk of pregnancy.
- If you miss a dose, follow the instructions provided in the package insert, and use a backup form of contraception (such as condoms) for 7 days if multiple pills are missed.
- Vyfemla does not protect against sexually transmitted infections (STIs). Consider using condoms for protection against STIs.
- Certain medications, such as antibiotics and anticonvulsants, may reduce the effectiveness of Vyfemla. Inform your healthcare provider about any medications or supplements you are taking.
Side Effects of Vyfemla
Common Side Effects
- Nausea
- Headache
- Breast tenderness
- Weight fluctuations
- Mood changes
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis or pulmonary embolism)
- Heart attack or stroke
- Liver problems, such as jaundice
- High blood pressure
Risks and Warnings of Vyfemla
- Smoking Risk: Smoking while using Vyfemla increases the risk of serious cardiovascular events, such as heart attack and stroke, particularly in women over 35.
- Blood Clot Risk: Combination oral contraceptives can increase the risk of blood clots, especially in women with other risk factors such as obesity, prolonged immobility, or a family history of clotting disorders.
- Breast Cancer: Women with a history of hormone-sensitive cancers or a strong family history of breast cancer should discuss alternative contraceptive options with their healthcare provider.
Interactions with Vyfemla
Common Drug Interactions
- Antibiotics: Certain antibiotics, like rifampin, may reduce the effectiveness of Vyfemla. Use a backup method of contraception during treatment with these medications.
- Anticonvulsants: Medications for seizure disorders may decrease the effectiveness of Vyfemla.
- St. John’s Wort: This herbal supplement can decrease the effectiveness of hormonal contraceptives like Vyfemla.
Alternatives to Vyfemla
- Ortho-Novum (norethindrone/ethinyl estradiol): Another combination oral contraceptive with a similar hormone profile.
- Junel Fe (norethindrone acetate/ethinyl estradiol): A low-dose alternative for birth control.
- NuvaRing (etonogestrel/ethinyl estradiol): A vaginal ring for women who prefer a non-pill method of contraception.
- Depo-Provera (medroxyprogesterone): A long-acting injectable contraceptive option.
