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Viberzi
Viberzi (generic name: eluxadoline) is a prescription medication used to treat irritable bowel syndrome with diarrhea (IBS-D). It works by activating opioid receptors in the gastrointestinal (GI) tract to reduce the symptoms of diarrhea and abdominal pain associated with IBS-D. Viberzi helps manage the overactivity of the bowel, providing relief from frequent bowel movements and discomfort without causing constipation.
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Frequently Asked Questions
How long does it take for Viberzi to start working?
Viberzi may start relieving symptoms of IBS-D, such as diarrhea and abdominal pain, within a few days, but it can take up to a few weeks for full effects.
Can I drink alcohol while taking Viberzi?
No, alcohol increases the risk of pancreatitis while taking Viberzi. It is important to avoid alcohol while on this medication.
What should I do if I miss a dose of Viberzi?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one.
Can I take Viberzi if I don't have a gallbladder?
Patients without a gallbladder are at increased risk for serious side effects, including pancreatitis. The 75 mg dose is recommended for these patients, but they should be closely monitored by their healthcare provider.
Does Viberzi cause constipation?
Yes, constipation is a common side effect of Viberzi. If constipation becomes severe, consult your healthcare provider.
Comprehensive Drug Guide
How Does Viberzi Work?
Viberzi works by stimulating mu-opioid receptors and blocking delta-opioid receptors in the gastrointestinal tract. This reduces bowel contractions, which helps to control diarrhea and alleviate abdominal pain. Unlike traditional opioid medications, Viberzi is designed to work primarily in the GI tract, with less risk of causing constipation.
Common Dosages
- 75 mg tablets
- 100 mg tablets
Typical Dosing
- The typical starting dose is 100 mg twice daily with food. For patients who cannot tolerate the higher dose, the 75 mg dose may be used.
- Patients without a gallbladder should take the 75 mg dose due to an increased risk of serious side effects, including pancreatitis.
Typical Dosing
FDA Approved Indications
- Treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.
Who Shouldn't Take Viberzi?
- Biliary duct obstruction or patients without a gallbladder.
- Pancreatitis or a history of pancreatitis.
- Severe liver impairment.
- Alcohol abuse or those who consume more than 3 alcoholic beverages per day.
- Known hypersensitivity to eluxadoline or any components of the medication.
Advice From The Pharmacist
- Take Viberzi twice daily with food to avoid stomach upset. Make sure to follow the dosing schedule as prescribed by your healthcare provider.
- Avoid alcohol consumption while taking Viberzi, as alcohol can increase the risk of serious side effects like pancreatitis.
- Report any signs of severe abdominal pain, which may indicate pancreatitis or other complications, especially if you do not have a gallbladder.
- Do not stop or change your dose of Viberzi without consulting your healthcare provider, as stopping suddenly may worsen IBS-D symptoms.
Side Effects of Viberzi
Common Side Effects
- Constipation
- Nausea
- Abdominal pain
- Vomiting
Uncommon/Severe Side Effects
- Pancreatitis, especially in patients without a gallbladder.
- Spasms of the sphincter of Oddi, which can cause severe abdominal pain and elevated liver enzymes.
- Severe constipation or bowel obstruction.
Risks and Warnings of Viberzi
- Pancreatitis Risk: Viberzi can cause pancreatitis, particularly in patients without a gallbladder. Symptoms include severe abdominal pain, nausea, and vomiting. If these symptoms occur, stop taking Viberzi and seek immediate medical attention.
- Sphincter of Oddi Dysfunction: Viberzi can cause spasms of the sphincter of Oddi, leading to increased liver enzymes and pancreatitis. Patients without a gallbladder are at higher risk.
- Alcohol Interaction: Drinking alcohol while on Viberzi increases the risk of pancreatitis. Patients are advised to avoid alcohol entirely during treatment.
Interactions with Viberzi
Common Drug Interactions
- Opioid medications: Combining Viberzi with other opioid-containing medications may increase the risk of constipation or more serious side effects like bowel obstruction.
- Medications that affect liver enzymes (e.g., cyclosporine): These may increase the levels of Viberzi in the blood and raise the risk of side effects.
- Anticholinergics: These drugs can exacerbate constipation when taken with Viberzi.
Alternatives to Viberzi
- Loperamide (Imodium): An over-the-counter antidiarrheal medication used to manage diarrhea in IBS-D.
- Alosetron (Lotronex): A prescription medication for women with severe IBS-D who have not responded to other treatments.
- Rifaximin (Xifaxan): An antibiotic used to treat IBS-D by altering gut bacteria.
