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Vestura
Vestura (generic name: drospirenone and ethinyl estradiol) is a combination oral contraceptive pill (OCP) used to prevent pregnancy. It contains two hormones: drospirenone, a progestin, and ethinyl estradiol, an estrogen. In addition to birth control, Vestura is sometimes used to treat moderate acne in women at least 14 years old and for managing premenstrual dysphoric disorder (PMDD). This combination prevents ovulation, thickens cervical mucus, and alters the uterine lining, making it harder for sperm to reach an egg and for a fertilized egg to implant.
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Frequently Asked Questions
Can I take Vestura if I smoke?
Smoking increases the risk of serious cardiovascular events while taking oral contraceptives like Vestura, especially in women over 35. It is strongly advised to quit smoking if you are using Vestura.
How long does it take for Vestura to become effective?
Vestura is effective after 7 days of consistent use. If starting the pill for the first time, use backup contraception (such as condoms) for the first week.
What should I do if I miss a dose of Vestura?
If you miss one pill, take it as soon as you remember and take the next pill at your regular time. If you miss two or more pills, follow the instructions in the packaging and use backup contraception for at least 7 days.
Does Vestura help with acne?
Yes, Vestura is FDA-approved to help treat moderate acne in women who desire oral contraception.
Can Vestura cause weight gain?
Some women may experience weight gain while taking Vestura, but it is not a common side effect. If you notice significant changes, talk to your healthcare provider.
Comprehensive Drug Guide
How Does Vestura Work?
Vestura works through a combination of actions. It prevents ovulation (the release of an egg from the ovaries) and causes changes in the cervical mucus, making it more difficult for sperm to enter the uterus. It also changes the lining of the uterus, making it less suitable for implantation. Drospirenone, a progestin, has anti-mineralocorticoid and anti-androgenic activity, which can help reduce acne and PMDD symptoms.
Common Dosages
- Oral tablets containing 3 mg drospirenone and 0.02 mg ethinyl estradiol.
Typical Dosing
- The usual dosing for Vestura is one tablet daily at the same time each day.
- A typical pack contains 24 active hormone pills followed by 4 inactive (placebo) pills. Menstruation usually occurs during the placebo pill days.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy in women.
- Treatment of moderate acne in women at least 14 years of age who desire contraception.
- Management of premenstrual dysphoric disorder (PMDD) in women who want to use an oral contraceptive for birth control.
Who Shouldn't Take Vestura?
- History of blood clots, deep vein thrombosis (DVT), or pulmonary embolism (PE).
- Cardiovascular disease or a history of stroke.
- Liver disease or liver tumors.
- Uncontrolled high blood pressure.
- Severe migraines with aura.
- Known or suspected pregnancy.
- Kidney failure or adrenal insufficiency.
Advice From The Pharmacist
- Take Vestura at the same time each day to maintain its effectiveness. If you miss a dose, follow the instructions provided in the packaging or consult your healthcare provider.
- Avoid smoking while taking Vestura, as smoking increases the risk of serious cardiovascular side effects, especially in women over the age of 35.
- Be aware of drug interactions: Some medications, such as antibiotics or anticonvulsants, may decrease the effectiveness of Vestura, leading to an increased risk of pregnancy.
- Report any symptoms of blood clots, such as leg pain, swelling, shortness of breath, or chest pain, to your healthcare provider immediately.
Side Effects of Vestura
Common Side Effects
- Nausea
- Breast tenderness
- Headache
- Weight gain
- Mood changes
- Menstrual irregularities
Uncommon/Severe Side Effects
- Blood clots (e.g., deep vein thrombosis, pulmonary embolism)
- Stroke
- Heart attack
- Severe hypertension
- Liver problems
Risks and Warnings of Vestura
- Blood Clots and Cardiovascular Risks: Vestura increases the risk of serious blood clots, heart attack, and stroke, particularly in women who smoke, are over the age of 35, or have other risk factors (e.g., obesity).
- Hyperkalemia: Drospirenone can raise potassium levels in the blood. Women with kidney disease, liver disease, or those taking certain medications (e.g., NSAIDs, potassium-sparing diuretics) should be monitored for hyperkalemia.
- Liver Dysfunction: Vestura may cause liver problems, and any signs of liver dysfunction, such as jaundice or abdominal pain, should be evaluated promptly.
Interactions with Vestura
Common Drug Interactions
- Antibiotics (e.g., rifampin): May reduce the effectiveness of Vestura.
- Anticonvulsants (e.g., phenytoin, carbamazepine): Can decrease contraceptive effectiveness.
- Potassium-sparing diuretics (e.g., spironolactone): May increase the risk of hyperkalemia when used with Vestura.
- St. John’s Wort: May reduce the effectiveness of Vestura.
Alternatives to Vestura
- Yaz: A similar combination birth control pill containing drospirenone and ethinyl estradiol.
- Ortho Tri-Cyclen: Another combination oral contraceptive that also helps treat acne.
- NuvaRing: A vaginal ring that releases hormones similar to Vestura for contraception.
- Progestin-only pills: A contraceptive option for women who cannot take estrogen-containing birth control.
