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Verquvo
Verquvo (generic name: vericiguat) is an oral medication used to treat adults with symptomatic chronic heart failure and reduced ejection fraction. It is specifically indicated for patients who have had a recent episode of heart failure or need hospitalization, helping to reduce the risk of cardiovascular death and heart failure hospitalization. Verquvo works by stimulating soluble guanylate cyclase (sGC), an enzyme in the cardiovascular system that helps relax blood vessels and improve heart function.
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Frequently Asked Questions
How long does it take for Verquvo to start working?
Verquvo works gradually to reduce the risk of heart failure symptoms and hospitalizations. It may take a few weeks of treatment to notice improvements in symptoms.
Can I take Verquvo with other heart failure medications?
Yes, Verquvo is often used alongside other heart failure medications such as beta-blockers, diuretics, and ACE inhibitors. Your healthcare provider will carefully monitor your treatment to ensure safety.
What should I do if I miss a dose of Verquvo?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Is Verquvo safe for long-term use?
Yes, Verquvo is designed for long-term use in managing heart failure. Regular monitoring by your healthcare provider will ensure that the medication is working effectively and safely.
Can Verquvo cause weight gain?
Weight gain is not a typical side effect of Verquvo, but patients with heart failure should monitor their weight regularly, as sudden increases may signal fluid retention or worsening heart failure.
Comprehensive Drug Guide
How Does Verquvo Work?
Verquvo works by stimulating soluble guanylate cyclase (sGC), which is a key enzyme in the nitric oxide signaling pathway. By increasing the production of cyclic guanosine monophosphate (cGMP), Verquvo helps to relax blood vessels, reduce vascular resistance, and improve heart function, thus helping patients with heart failure by improving blood flow and reducing the strain on the heart.
Common Dosages
- 2.5 mg, 5 mg, and 10 mg oral tablets
Typical Dosing
- Initial dose: Start with 2.5 mg once daily.
- Titration: Increase to 5 mg once daily after 2 weeks, then to 10 mg once daily as the target maintenance dose, based on patient tolerance.
- Take with food to improve absorption.
Typical Dosing
FDA Approved Indications
- Reducing the risk of cardiovascular death and hospitalization in adults with symptomatic chronic heart failure and reduced ejection fraction, following a recent worsening event such as hospitalization or the need for intravenous diuretics.
Who Shouldn't Take Verquvo?
- Pregnancy: Verquvo may harm an unborn baby and should not be used during pregnancy. Females of reproductive potential should use effective contraception during treatment.
- Hypersensitivity: Known allergy to vericiguat or any components of the formulation.
Advice From The Pharmacist
- Take Verquvo with food to enhance absorption. It is usually taken once daily at the same time each day.
- Regular monitoring of blood pressure is important while taking Verquvo, as it can cause low blood pressure (hypotension).
- Avoid becoming pregnant while taking Verquvo. Women of childbearing potential should use contraception, and pregnancy tests are recommended before starting treatment.
- Do not stop taking Verquvo suddenly without consulting your doctor, as this may worsen your heart condition.
Side Effects of Verquvo
Common Side Effects
- Low blood pressure (hypotension)
- Dizziness
- Fatigue
- Anemia
Uncommon/Severe Side Effects
- Severe hypotension (dangerously low blood pressure)
- Fainting
Risks and Warnings of Verquvo
- Hypotension: Verquvo can cause low blood pressure, which may lead to dizziness or fainting. Patients with a history of low blood pressure should be monitored closely.
- Anemia: Some patients may develop anemia while on Verquvo. Regular blood tests may be necessary to monitor hemoglobin levels.
- Pregnancy Risk: Verquvo can harm an unborn baby. It is important to use effective contraception during treatment and avoid pregnancy while taking Verquvo.
Interactions with Verquvo
Common Drug Interactions
- Phosphodiesterase-5 (PDE-5) inhibitors (e.g., sildenafil, tadalafil): Using these medications with Verquvo may increase the risk of low blood pressure.
- Blood pressure medications: Verquvo may interact with other antihypertensive drugs, increasing the risk of hypotension.
- Nitrates (e.g., nitroglycerin): Verquvo should not be used in combination with nitrates, as it can lead to a dangerous drop in blood pressure.
Alternatives to Verquvo
- Entresto (sacubitril/valsartan): Another heart failure medication used to reduce the risk of cardiovascular death and hospitalization in patients with chronic heart failure.
- Beta-blockers (e.g., carvedilol, metoprolol): Commonly used in heart failure patients to improve heart function and reduce hospitalizations.
- ACE inhibitors (e.g., lisinopril, enalapril): Often used to manage heart failure by relaxing blood vessels and improving blood flow.
