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Varivax
Varivax is a live attenuated vaccine used to prevent varicella (chickenpox), a highly contagious viral disease caused by the varicella-zoster virus. It is commonly administered to children, adolescents, and adults who have never had chickenpox or have not been vaccinated against the virus. The vaccine helps the body develop immunity against varicella, preventing infection or reducing the severity of symptoms if infection occurs.
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Frequently Asked Questions
How effective is Varivax at preventing chickenpox?
Varivax is highly effective, providing about 90% to 98% protection against chickenpox after two doses.
How effective is Varivax at preventing chickenpox?
Varivax is highly effective, providing about 90% to 98% protection against chickenpox after two doses.
Can I still get chickenpox after being vaccinated with Varivax?
Yes, though it’s rare. If a vaccinated person does develop chickenpox, the symptoms are usually much milder with fewer lesions and less severe illness.
Is Varivax safe for adults who have never had chickenpox?
Yes, Varivax is safe for adults who have never had chickenpox. Adults at risk of exposure should receive two doses, 4 to 8 weeks apart.
Can Varivax be given with other vaccines?
Yes, Varivax can be given at the same time as other vaccines, such as the MMR vaccine, as long as they are administered at different injection sites or according to recommended guidelines.
Can I receive Varivax if I have a cold or mild illness?
Yes, Varivax can generally be administered if you have a mild illness, such as a cold. However, if you are experiencing a moderate or severe illness, you should wait until you have recovered before receiving the vaccine.
Comprehensive Drug Guide
How Does Varivax Work?
Varivax contains a weakened form of the varicella-zoster virus, which stimulates the immune system to produce antibodies. These antibodies protect against chickenpox by recognizing and neutralizing the virus if the vaccinated individual is exposed to it in the future.
Common Dosages
- Children aged 12 months to 12 years: One dose of 0.5 mL, followed by a second dose at least 3 months later.
- Adolescents and adults aged 13 years and older: Two doses of 0.5 mL administered 4 to 8 weeks apart.
Typical Dosing
- First dose: Given at 12 to 15 months of age.
- Second dose: Typically administered at 4 to 6 years of age, though it can be given earlier if necessary, with at least 3 months between doses.
Typical Dosing
FDA Approved Indications
- Prevention of varicella (chickenpox) in individuals aged 12 months and older who have not previously had chickenpox or been vaccinated.
Who Shouldn't Take Varivax?
- Pregnancy (women should avoid pregnancy for at least 1 month after vaccination).
- Severe immunodeficiency (e.g., individuals undergoing chemotherapy, or those with HIV/AIDS).
- Known hypersensitivity to varicella vaccine or any of its components, including gelatin and neomycin.
Advice From The Pharmacist
- After receiving Varivax, individuals should avoid close contact with pregnant women or immunocompromised individuals for several weeks, as the vaccine contains a live virus that could potentially spread in rare cases.
- If you develop a rash after receiving Varivax, avoid close contact with people who are not immune to chickenpox.
- Women should avoid becoming pregnant for at least 1 month after receiving the Varivax vaccine.
- Store the vaccine properly if you are receiving it from a pharmacy for administration.
Side Effects of Varivax
Common Side Effects
- Injection site reactions (redness, swelling, or soreness)
- Fever
- Mild rash (similar to chickenpox)
Uncommon/Severe Side Effects
- Severe allergic reactions (hives, swelling, difficulty breathing)
- Seizures (associated with fever)
- Pneumonia or encephalitis (in extremely rare cases, particularly in immunocompromised individuals)
Risks and Warnings of Varivax
- Pregnancy: Varivax is contraindicated in pregnancy. Women should avoid becoming pregnant for at least 1 month after vaccination, as the live virus may cause harm to the fetus.
- Immunocompromised Individuals: Varivax is a live vaccine and should not be given to individuals with weakened immune systems due to the risk of developing a more severe form of varicella infection.
- Vaccine-Related Rash: In rare cases, individuals may develop a mild rash after vaccination, which may contain the live virus. This could potentially spread to others, so isolation may be recommended until the rash resolves.
Interactions with Varivax
Common Drug Interactions
- Immunosuppressive medications (e.g., corticosteroids, chemotherapy): These medications can reduce the effectiveness of Varivax and increase the risk of serious side effects.
- Other live vaccines: If other live vaccines (e.g., MMR) are needed, they should be given at the same time as Varivax or spaced at least 28 days apart.
- Antiviral medications (e.g., acyclovir): Antiviral drugs may interfere with the efficacy of the vaccine. Avoid these medications for 24 hours before and 14 days after vaccination.
Alternatives to Varivax
- MMRV (Measles, Mumps, Rubella, and Varicella) vaccine: This combination vaccine protects against measles, mumps, rubella, and chickenpox in a single injection.
- Shingrix: A vaccine to prevent shingles, a reactivation of the varicella-zoster virus in individuals who have had chickenpox in the past.
