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Ursodiol
Ursodiol is a type of medication that helps dissolve certain types of gallstones in the body, particularly the ones formed from cholesterol. Given its unique property, it's also used for treating primary biliary cirrhosis, a liver disease.
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Frequently Asked Questions
Can I stop taking Ursodiol after my gallstones dissolve?
Nope. You should continue your prescribed dose even after gallstones have dissolved since they can recur if treatment is stopped.
Can I take Ursodiol if I have liver disease?
Yes, it can often be used in treating certain liver conditions. But always consult with your healthcare provider first.
Does Ursodiol aid in weight loss?
No, Ursodiol is not a weightloss drug. Rather, it is used to help dissolve certain types of gallstones formed from cholesterol.
What should I do if I miss a dose of Ursodiol?
No worries! Simply take your missed dose as soon as you remember. But if it's near the time for your next dose, skip the missed dose and stick to your regular schedule ? never double up!
Comprehensive Drug Guide
How Does Ursodiol Work?
Ursodiol is a naturally occurring bile acid that decreases the production of cholesterol and dissolves it in bile, preventing the formation of gallstones. It also reduces liver damage by displacing toxic bile acids.
What is Ursodiol Used For?
FDA indications: Ursodiol is best known for its role in gallstone prevention for highrisk patients undergoing rapid weight loss, and for treating primary biliary cirrhosis.
Offlabel uses: It is used offlabel for treating primary sclerosing cholangitis, a diseasecausing inflammation, scarring, and destruction of the bile ducts inside and outside of the liver.
Common Dosages
Tablets: 250mg, 500mg
Typical Dosing
FDA Approved Indications
- For gallstones: 810 mg/kg/day, divided into 23 doses.
- For primary biliary Cholangitis: 1315 mg/kg/day, divided into 23 doses.
Who Shouldn't Take Ursodiol?
- Have a hypersensitivity to Ursodiol or any of its components.
- Have a gallbladder that cannot contract properly
- Have bile duct blockage or certain gallbladder conditions.
- Have or suspect a gallbladder infection.
- Have frequent gallstone complications.
Advice From The Pharmacist
- Take Ursodiol consistently with meals or snacks that contain fats to increase its absorption.
- Don't stop taking the medication abruptly without your healthcare provider's guidance.
- Keep your appointments! Regular liver and gallstone tests will be essential during Ursodiol treatment.
- Report any new or worsening symptoms to your healthcare provider.
Side Effects of Ursodiol
Common Side Effects
- You might experience some stomach discomfort.
- Diarrhea is also a possibility.
Uncommon/Severe Side Effects
- Rare Side Effects:
- You might see weight gain or hair loss.
- Severe Side Effects:
- Continuous or severe stomach discomfort, bloody or tarry stools, or yellowing of the skin/eyes are serious signs that require immediate medical attention.
Risks and Warnings of Ursodiol
- Remember, Ursodiol might not be suitable for everyone. It cannot be used if you have a blockage in the bile ducts of your liver or gallbladder.
- It may not be effective if you have gallstones larger than 20mm, calcified gallstones, radiopaque stones, or acute cholecystitis.
Interactions with Ursodiol
Common Drug Interactions
- Cholestyramine
- Colestipol
- Aluminumbased antacids
- Estradiol
Alternatives to Ursodiol
- Chenodiol
- Obeticholic acid
