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Uloric
Uloric (generic name: febuxostat) is a prescription medication used to treat gout, a type of arthritis caused by high levels of uric acid in the blood. It works by lowering uric acid levels, which helps prevent the formation of uric acid crystals that can cause painful joint inflammation and kidney stones. Uloric is typically prescribed when other treatments, such as allopurinol, have not been effective or have caused side effects.
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Frequently Asked Questions
How long does it take for Uloric to lower uric acid levels?
Uloric begins to lower uric acid levels within 2 to 4 weeks, but it may take several months of consistent use to achieve optimal uric acid control and prevent gout flares.
Can I take Uloric during a gout flare?
Yes, you should continue taking Uloric during a gout flare, but additional medications may be needed to manage the pain and inflammation of the flare itself.
How often do I need blood tests while taking Uloric?
Your healthcare provider may recommend regular blood tests to monitor your uric acid levels, liver function, and kidney function. The frequency of testing will depend on your individual treatment plan.
What should I do if I miss a dose of Uloric?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Is Uloric safe for long-term use?
Uloric can be used for long-term management of gout and hyperuricemia, but patients should be regularly monitored for side effects, particularly cardiovascular and liver-related issues. Always follow your healthcare provider’s advice on long-term treatment.
Comprehensive Drug Guide
How Does Uloric Work?
Uloric works by inhibiting the enzyme xanthine oxidase, which is responsible for the conversion of purines into uric acid. By blocking this enzyme, Uloric reduces the production of uric acid in the body, lowering blood uric acid levels and preventing the formation of crystals in the joints and kidneys that lead to gout flares and other complications.
Common Dosages
- 40 mg once daily for patients with mild to moderate hyperuricemia.
- 80 mg once daily for patients who do not achieve adequate uric acid control on the 40 mg dose.
Typical Dosing
- The usual starting dose is 40 mg once daily, which may be increased to 80 mg once daily based on the patient’s uric acid levels and response to treatment.
- Uloric can be taken with or without food.
Typical Dosing
FDA Approved Indications
- Management of hyperuricemia (elevated uric acid levels) in patients with gout.
Who Shouldn't Take Uloric?
- Known hypersensitivity to febuxostat or any other component of the medication.
- Patients being treated with azathioprine, mercaptopurine, or theophylline, as the combination can increase the risk of serious toxicity.
Advice From The Pharmacist
- Take Uloric exactly as prescribed, usually once a day.
- Drink plenty of fluids to help flush out uric acid and prevent kidney stones.
- Do not stop taking Uloric during a gout flare, as stopping suddenly may worsen symptoms. Continue your treatment as directed by your healthcare provider, and use additional medications to manage flare-ups if necessary.
- Regular blood tests may be needed to monitor your uric acid levels and kidney function.
Side Effects of Uloric
Common Side Effects
- Nausea
- Joint pain
- Liver function abnormalities (elevated liver enzymes)
- Rash
Uncommon/Severe Side Effects
- Cardiovascular events, such as heart attack or stroke
- Severe allergic reactions (rash, hives, swelling, difficulty breathing)
- Liver toxicity
Risks and Warnings of Uloric
- Cardiovascular Risk: Uloric may increase the risk of serious cardiovascular events, including heart attack, stroke, and death, particularly in patients with pre-existing cardiovascular disease. Patients should be closely monitored for signs of heart problems, and alternative treatments may be considered for those at high risk.
- Liver Toxicity: Uloric can affect liver function. Patients should have their liver enzymes monitored regularly, and the medication should be discontinued if signs of liver damage appear.
- Gout Flare Risk: Starting Uloric can trigger gout flares in the early stages of treatment. This is common with medications that lower uric acid levels. Your healthcare provider may prescribe additional medications, such as colchicine or NSAIDs, to help manage flares during the initial months of therapy.
Interactions with Uloric
Common Drug Interactions
- Azathioprine, Mercaptopurine, and Theophylline: Uloric should not be used with these medications, as it can increase their levels and lead to serious side effects.
- Antacids: Antacids containing aluminum or magnesium may reduce the absorption of Uloric if taken at the same time. Space doses apart by at least 2 hours.
Alternatives to Uloric
- Allopurinol: Another xanthine oxidase inhibitor that is often the first-line treatment for gout and hyperuricemia.
- Probenecid: A medication that increases the excretion of uric acid in the urine, used to treat hyperuricemia in patients who cannot tolerate xanthine oxidase inhibitors.
- Colchicine: Used to prevent or treat acute gout attacks, often in combination with uric acid-lowering medications like Uloric or allopurinol.
- Pegloticase (Krystexxa): An injectable medication used in severe, treatment-resistant gout.
