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Twinrix
Twinrix is a combination vaccine that provides protection against hepatitis A and hepatitis B. It is used to prevent infections caused by both hepatitis A virus (HAV) and hepatitis B virus (HBV). Hepatitis A is typically transmitted through contaminated food and water, while hepatitis B is transmitted through blood, sexual contact, or from mother to child. Twinrix is often recommended for individuals traveling to areas where hepatitis A and B are common, or for those at risk of exposure to these viruses.
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Frequently Asked Questions
How long does protection from Twinrix last?
Protection against hepatitis A and B is long-lasting, and many individuals have lifetime immunity after completing the full series. For hepatitis B, a blood test can confirm immunity if needed.
Who should get the Twinrix vaccine?
Twinrix is recommended for adults and children aged 18 years and older who are at risk of hepatitis A and B, such as travelers to areas with high rates of these infections, healthcare workers, and individuals with chronic liver disease.
Can I receive Twinrix if I’m pregnant?
Twinrix is generally considered safe during pregnancy, but it is important to discuss the risks and benefits with your healthcare provider before receiving the vaccine.
What should I do if I miss a dose of the Twinrix vaccine?
If you miss a dose, schedule a catch-up dose with your healthcare provider. It is important to complete the full series for maximum protection.
Can Twinrix be given with other vaccines?
Yes, Twinrix can be administered alongside other vaccines, but it should be given at a different injection site.
Comprehensive Drug Guide
How Does Twinrix Work?
Twinrix works by stimulating the immune system to produce antibodies against both hepatitis A and hepatitis B viruses. It contains inactivated hepatitis A virus and hepatitis B surface antigen (HBsAg), which help the body recognize and fight these viruses if exposed in the future. The vaccine does not cause hepatitis A or B infection.
Common Dosages
- First dose: At an elected date.
- Second dose: 1 month after the first dose.
- Third dose: 6 months after the first dose.
For individuals needing faster protection, an accelerated schedule is also available:
- First dose: At an elected date.
- Second dose: 7 days after the first dose.
- Third dose: 21 days after the first dose.
- Booster dose: 12 months after the first dose.
Typical Dosing
- Standard dosing schedule: Three doses given over 6 months.
- Accelerated dosing schedule: Three doses over 21 days, with a booster dose at 12 months.
Typical Dosing
FDA Approved Indications
- Prevention of hepatitis A and hepatitis B in adults and children aged 18 years and older who are at risk of exposure to these viruses.
Who Shouldn't Take Twinrix?
- Known hypersensitivity to any component of the vaccine, including neomycin.
- Severe allergic reactions (anaphylaxis) to previous hepatitis A or B vaccines.
- Individuals with a severe febrile illness should delay vaccination until recovery.
Advice From The Pharmacist
- Twinrix is typically administered in the deltoid muscle (upper arm) by a healthcare professional.
- Complete the full series of doses to ensure maximum protection. If you miss a dose, speak to your healthcare provider about scheduling a catch-up dose.
- You may experience mild side effects such as soreness at the injection site, tiredness, or mild fever after vaccination.
- Even after vaccination, continue to practice safe hygiene and take precautions, especially in high-risk areas or situations.
Side Effects of Twinrix
Common Side Effects
- Soreness, redness, or swelling at the injection site
- Fatigue
- Headache
- Mild fever
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (hives, difficulty breathing, swelling of the face or throat)
- Fainting or dizziness
- Unusual bleeding or bruising
Risks and Warnings of Twinrix
- Allergic Reactions: Twinrix contains neomycin, and individuals allergic to this component should not receive the vaccine. Watch for signs of severe allergic reactions and seek immediate medical attention if they occur.
- Immune System Response: Individuals with weakened immune systems (e.g., those with HIV or undergoing chemotherapy) may not respond as well to the vaccine. Consult your healthcare provider to discuss the risks and benefits of vaccination in these cases.
- Incomplete Immunity: Full protection against hepatitis A and B requires completion of the full vaccination series. Partial vaccination may not provide full immunity.
Interactions with Twinrix
Common Drug Interactions
- Immunosuppressive therapies: Medications like corticosteroids, chemotherapy, or immunosuppressants may reduce the immune response to the vaccine. Consult with your healthcare provider before receiving the vaccine if you are undergoing such treatments.
- Other vaccines: Twinrix can be administered at the same time as other vaccines, but different injection sites should be used.
Alternatives to Twinrix
- Havrix or Vaqta: Vaccines that protect against hepatitis A only.
- Engerix-B or Recombivax HB: Vaccines that protect against hepatitis B only.
- Heplisav-B: A newer hepatitis B vaccine that requires only two doses over one month.
