You're not logged in. Please log in to earn stock or Bitcoin rewards on your prescription purchase.
Trijardy XR
Trijardy XR is the generic version of the combination drug containing empagliflozin, linagliptin, and metformin hydrochloride extended-release. It is prescribed to help manage type 2 diabetes mellitus in adults, aiding in controlling blood sugar levels. Trijardy XR combines three different classes of medications: empagliflozin (a sodium-glucose co-transporter 2 [SGLT2] inhibitor), linagliptin (a dipeptidyl peptidase-4 [DPP-4] inhibitor), and metformin (a biguanide). Together, they work to reduce blood glucose levels in different ways, which can improve glycemic control when diet and exercise alone are not sufficient.
Rx. Enter your prescription
How would you like to get your prescription? Select an option
Pharmacy pickup
Select from 35,000 pharmacies
Free two-day delivery
Coming soon!
Find a pharmacy near you. Enter your ZIP code
Are you a member? Sign up or log in.
Members have saved
$NaN
using our savings card for instant savings.
Don't pay full retail price and miss out on potential savings. Try it now—you have nothing to lose!
NaNM
worth of Satoshi has been rewarded to our members.
Everyone who signs up enjoys the benefits of earning FREE Bitcoin with every purchase.
How much Bitcoin can you earn with Trijardy XR ?
The potential for Bitcoin rewards to increase and appreciate in value is a possibility to consider, which may occur over time.
See the value of your savings today
Today's Value
1 Bitcoin = $NaN
Bitcoin (BTC)
...
USD
$NaN
Adjust Bitcoin's potential value to see how much it could be worth
Potential Value
1 Bitcoin =
Bitcoin (BTC)
...
USD
$NaN
Frequently Asked Questions
How long does it take for Trijardy XR to start working?
It may take a few days to weeks to notice improved blood sugar control after starting Trijardy XR.
Can I take Trijardy XR with other diabetes medications?
Yes, but you should consult your healthcare provider to adjust doses to avoid low blood sugar or other side effects.
Should I stop taking Trijardy XR if I get sick?
If you become severely ill or dehydrated, especially with vomiting or diarrhea, you should contact your healthcare provider, as you may need to temporarily stop taking the medication.
What should I do if I miss a dose of Trijardy XR?
Take the missed dose as soon as you remember, but if it is almost time for your next dose, skip the missed dose. Do not take two doses at once.
Can Trijardy XR help with weight loss?
Empagliflozin, one of the components of Trijardy XR, may help with modest weight loss due to its effects on glucose excretion. However, it is not a weight-loss medication.
Comprehensive Drug Guide
How Does Trijardy XR Work?
- Empagliflozin (SGLT2 inhibitor) helps the kidneys remove excess glucose from the bloodstream through urine.
- Linagliptin (DPP-4 inhibitor) increases the levels of incretin hormones, which help stimulate insulin release and decrease blood glucose production in the liver.
- Metformin (biguanide) reduces glucose production in the liver and increases the sensitivity of muscle cells to insulin, helping glucose move into cells more effectively.
Together, these mechanisms help control blood sugar in people with type 2 diabetes.
What is Trijardy XR Used For?
Common Dosages
- Tablets in combinations of:
- Empagliflozin 5 mg / Linagliptin 5 mg / Metformin XR 1000 mg
- Empagliflozin 12.5 mg / Linagliptin 5 mg / Metformin XR 1000 mg
Typical Dosing
- The typical starting dose for adults is based on the patient's current treatment and may range from one tablet of the lowest available dose, taken once daily, to the higher strength depending on how well blood sugar is controlled.
- Trijardy XR should be taken with meals to minimize gastrointestinal side effects from metformin.
Typical Dosing
FDA Approved Indications
- Type 2 diabetes mellitus in adults as an adjunct to diet and exercise to improve glycemic control.
Off-label uses include:
Who Shouldn't Take Trijardy XR?
- Severe renal impairment, end-stage renal disease, or patients on dialysis
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis
- Known hypersensitivity to empagliflozin, linagliptin, metformin, or any component of the formulation
Advice From The Pharmacist
- Take Trijardy XR with food to reduce stomach upset from the metformin component.
- Stay well-hydrated to avoid dehydration, which can be a risk with empagliflozin.
- If you experience any symptoms of lactic acidosis (such as muscle pain, difficulty breathing, or unusual sleepiness), seek medical attention immediately.
- Regular monitoring of blood sugar levels is important to ensure that Trijardy XR is effectively controlling your diabetes.
- Avoid excessive alcohol use while taking this medication as it can increase the risk of lactic acidosis.
Side Effects of Trijardy XR
Common Side Effects
- Nausea
- Diarrhea
- Upper respiratory infections
- Urinary tract infections
Uncommon/Severe Side Effects
- Lactic acidosis (a rare but serious complication linked to metformin)
- Dehydration or low blood pressure (due to empagliflozin)
- Hypoglycemia (low blood sugar)
- Pancreatitis (linked to linagliptin)
Risks and Warnings of Trijardy XR
- Lactic Acidosis: A rare but potentially life-threatening condition associated with metformin, particularly in patients with kidney problems or dehydration.
- Dehydration and Kidney Issues: Empagliflozin can increase the risk of dehydration and kidney problems, especially in older adults.
- Pancreatitis: Linagliptin has been associated with an increased risk of pancreatitis. Any unexplained stomach pain should be reported to a healthcare provider.
- Hypoglycemia: Trijardy XR may increase the risk of low blood sugar when used with other diabetes medications such as insulin or sulfonylureas.
Interactions with Trijardy XR
Common Drug Interactions
- Diuretics: Trijardy XR may increase the risk of dehydration if used with diuretics.
- Insulin and Sulfonylureas: Combining Trijardy XR with these drugs can increase the risk of hypoglycemia.
- Alcohol: Should be avoided due to the increased risk of lactic acidosis with metformin.
- Beta-blockers: These may mask the symptoms of hypoglycemia.
Alternatives to Trijardy XR
- Jardiance (empagliflozin): An SGLT2 inhibitor used for type 2 diabetes.
- Janumet (sitagliptin/metformin): A combination of a DPP-4 inhibitor and metformin.
- Synjardy XR (empagliflozin/metformin): Another combination of empagliflozin and metformin.
- Invokamet (canagliflozin/metformin): A combination of an SGLT2 inhibitor and metformin.
