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Tri-Lo-Sprintec

Tri-Lo-Sprintec is the generic version of Ortho Tri-Cyclen Lo, a combination oral contraceptive used to prevent pregnancy. It contains two hormones: ethinyl estradiol (an estrogen) and norgestimate (a progestin). These hormones work together to prevent ovulation, change the uterine lining, and alter cervical mucus to make it harder for sperm to reach the uterus. Tri-Lo-Sprintec is taken in a 28-day cycle with varying hormone levels, which helps mimic the body’s natural menstrual cycle.



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Frequently Asked Questions

Can I use Tri-Lo-Sprintec if I have a history of migraines?
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Some women with a history of migraines, especially those with aura, may be advised to avoid combination hormonal contraceptives due to an increased risk of stroke. Discuss your medical history with your healthcare provider.

What should I do if I miss a dose of Tri-Lo-Sprintec?
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If you miss one active pill, take it as soon as you remember and take the next pill at your regular time. If you miss more than one pill, consult the instructions provided with your medication or contact your healthcare provider for guidance.

Can Tri-Lo-Sprintec help with acne?
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Yes, Tri-Lo-Sprintec is FDA-approved for the treatment of moderate acne in women aged 15 and older who also desire contraception.

Does Tri-Lo-Sprintec cause weight gain?
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Some women may experience slight weight gain due to fluid retention or other hormonal changes while on Tri-Lo-Sprintec, but significant weight changes are uncommon.

Can I stop taking Tri-Lo-Sprintec whenever I want?
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Yes, you can stop taking Tri-Lo-Sprintec at any time. However, if you stop taking it and do not switch to another form of contraception, you will be at risk for pregnancy. If you stop, consult your healthcare provider for guidance on alternative methods.

Comprehensive Drug Guide

How Does Tri-Lo-Sprintec Work?

Tri-Lo-Sprintec works by delivering synthetic estrogen and progestin to prevent ovulation (the release of an egg). Additionally, it thickens cervical mucus, making it difficult for sperm to enter the uterus, and alters the lining of the uterus to prevent implantation of a fertilized egg. These actions combined effectively prevent pregnancy.



Common Dosages

  • 21 active tablets (varying levels of hormones)
  • 7 inactive tablets (placebo week)

Typical Dosing

  • Take one active pill daily for 21 days, followed by one placebo pill daily for 7 days.
  • After completing the 28-day cycle, start a new pack immediately, regardless of whether menstruation has started or ended.

Typical Dosing

FDA Approved Indications

  • Contraception (prevention of pregnancy)
  • Moderate acne treatment in females at least 15 years old, who have started menstruation and desire oral contraceptive therapy


Who Shouldn't Take Tri-Lo-Sprintec?

  • History of blood clots, stroke, or heart attack
  • Uncontrolled hypertension
  • Liver disease
  • Known or suspected breast cancer or other estrogen- or progestin-sensitive cancers
  • Pregnancy


Advice From The Pharmacist

  • Take Tri-Lo-Sprintec at the same time every day to maintain consistent hormone levels and maximize effectiveness.
  • If you miss a pill, follow the instructions provided with the pack to determine whether you need backup contraception.
  • Tri-Lo-Sprintec does not protect against sexually transmitted infections (STIs); using condoms is recommended for STI prevention.
  • Keep your pills in a cool, dry place and take care to start your next pack on time.


Side Effects of Tri-Lo-Sprintec

Common Side Effects

  • Nausea
  • Breast tenderness
  • Headache
  • Weight gain
  • Mood changes


Uncommon/Severe Side Effects

  • Blood clots
  • Stroke or heart attack
  • High blood pressure
  • Liver problems


Risks and Warnings of Tri-Lo-Sprintec

  • Blood Clot Risk: Women who smoke and are over 35 years old are at an increased risk of developing blood clots while using Tri-Lo-Sprintec. It is important to stop smoking if you use this contraceptive.
  • Cancer Risk: Prolonged use of hormonal contraceptives may increase the risk of breast cancer or liver tumors in some women.
  • Hypertension: Tri-Lo-Sprintec can cause or worsen high blood pressure. Monitor your blood pressure regularly while taking this medication.


Interactions with Tri-Lo-Sprintec

Common Drug Interactions

  • Antibiotics: Certain antibiotics, such as rifampin, may decrease the effectiveness of Tri-Lo-Sprintec.
  • Anticonvulsants: Some anticonvulsant medications may reduce the effectiveness of Tri-Lo-Sprintec.
  • St. John's Wort: This herbal supplement can lower the efficacy of hormonal contraceptives.
  • HIV medications: Some medications used to treat HIV may interact with oral contraceptives.


Alternatives to Tri-Lo-Sprintec

  • Lo Loestrin Fe: A low-dose combination contraceptive with estrogen and progestin, like Tri-Lo-Sprintec.
  • Yaz: A combination contraceptive that also contains drospirenone, which may have additional benefits for women with acne.
  • Depo-Provera: A progestin-only contraceptive that is injected every three months.
  • IUD (Intrauterine Device): A non-hormonal or hormonal long-term contraceptive device inserted by a healthcare provider.