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Tri-Lo-Estarylla
Tri-Lo-Estarylla is an oral contraceptive that contains two hormones: norgestimate (a progestin) and ethinyl estradiol (an estrogen). It is primarily used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining, making it harder for sperm to enter the uterus and for a fertilized egg to implant. Tri-Lo-Estarylla is also used to treat acne in women who desire birth control and are at least 15 years of age.
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Frequently Asked Questions
How long does it take for Tri-Lo-Estarylla to become effective?
If you start Tri-Lo-Estarylla on the first day of your period, it is effective immediately. If you start on any other day, use a backup method of contraception (e.g., condoms) for the first 7 days.
Can Tri-Lo-Estarylla cause weight gain?
Some women may experience weight gain due to water retention or changes in appetite while taking Tri-Lo-Estarylla. However, not all women experience this side effect.
What should I do if I miss a pill?
If you miss one pill, take it as soon as you remember, then continue taking your pills as usual. If you miss two or more pills, consult the package insert and use backup contraception for at least 7 days.
Can Tri-Lo-Estarylla help with acne?
Yes, Tri-Lo-Estarylla is FDA-approved to treat moderate acne in women who also desire contraception and are at least 15 years old.
Is it safe to use Tri-Lo-Estarylla while breastfeeding?
Tri-Lo-Estarylla may reduce milk production and is generally not recommended during breastfeeding. Progestin-only contraceptives are preferred for breastfeeding women.
Comprehensive Drug Guide
How Does Tri-Lo-Estarylla Work?
- Prevents ovulation: Stops the release of an egg from the ovaries.
- Thickens cervical mucus: Makes it more difficult for sperm to enter the uterus.
- Alters the uterine lining: Reduces the likelihood of a fertilized egg implanting in the uterus.
Common Dosages
- 21 active tablets with varying doses of hormones (norgestimate and ethinyl estradiol).
- Days 1–7: 0.18 mg norgestimate / 0.025 mg ethinyl estradiol
- Days 8–14: 0.215 mg norgestimate / 0.025 mg ethinyl estradiol
- Days 15–21: 0.25 mg norgestimate / 0.025 mg ethinyl estradiol
- 7 placebo (inactive) tablets for the last week.
Typical Dosing
- Take one tablet daily, starting either on the first day of your period or the first Sunday after your period begins.
- Continue taking one pill daily for 28 days, including the 7 placebo pills.
- Use backup contraception (such as condoms) for the first 7 days if starting on any day other than the first day of your menstrual cycle.
Typical Dosing
FDA Approved Indications
- Prevention of pregnancy.
- Treatment of moderate acne in women at least 15 years old who seek contraception.
Who Shouldn't Take Tri-Lo-Estarylla?
- History of blood clots, deep vein thrombosis (DVT), or pulmonary embolism.
- History of stroke or heart attack.
- Uncontrolled hypertension.
- Certain types of cancers (breast, uterine, or liver cancer).
- Liver disease.
- Known hypersensitivity to norgestimate, ethinyl estradiol, or any other components.
- Smokers over 35 years of age due to an increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Tri-Lo-Estarylla at the same time each day to ensure its effectiveness. Setting an alarm can help remind you to take it consistently.
- If you miss a pill, refer to the package insert for instructions and use a backup method of contraception (e.g., condoms) if necessary.
- Tri-Lo-Estarylla does not protect against sexually transmitted infections (STIs). Use condoms to reduce the risk of STIs.
- Inform your doctor if you experience unusual symptoms such as severe leg pain, shortness of breath, or chest pain, as these could be signs of a serious blood clot.
Side Effects of Tri-Lo-Estarylla
Common Side Effects
- Nausea
- Headache
- Breast tenderness
- Weight gain
- Mood changes
- Breakthrough bleeding or spotting
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Stroke or heart attack
- Liver problems
- Severe migraines
Risks and Warnings of Tri-Lo-Estarylla
- Blood Clots: Women who smoke and are over 35 years old are at an increased risk of developing blood clots, heart attack, or stroke while using Tri-Lo-Estarylla. It is strongly advised to quit smoking while on this medication.
- Cardiovascular Events: Women with a history of hypertension, diabetes, or high cholesterol have an elevated risk of cardiovascular issues while taking combination oral contraceptives. Discuss with your doctor if you fall into this category.
- Liver Tumors: Rarely, benign liver tumors can occur with long-term use of hormonal contraceptives. Seek medical attention if you notice yellowing of the skin or eyes, severe abdominal pain, or dark urine.
- Vision Problems: Tri-Lo-Estarylla may increase the risk of retinal vein thrombosis, which can affect vision. Contact your doctor if you experience sudden vision loss or changes.
Interactions with Tri-Lo-Estarylla
Common Drug Interactions
- Antibiotics: Some antibiotics, such as rifampin, can reduce the effectiveness of Tri-Lo-Estarylla. Use a backup method of contraception if taking these medications.
- Anticonvulsants: Drugs like phenytoin or carbamazepine may lower the effectiveness of hormonal birth control.
- St. John's Wort: This herbal supplement can decrease the effectiveness of Tri-Lo-Estarylla, increasing the risk of pregnancy.
- Antifungal medications (e.g., ketoconazole): May increase hormone levels and side effects.
Alternatives to Tri-Lo-Estarylla
- Ortho Tri-Cyclen Lo: A similar triphasic oral contraceptive with different doses of hormones.
- Lo Loestrin Fe: A low-dose oral contraceptive containing norethindrone and ethinyl estradiol.
- NuvaRing: A vaginal ring that releases hormones to prevent pregnancy.
- Depo-Provera: A contraceptive injection given every 3 months.
