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Trelegy Ellipta
Trelegy Ellipta is a prescription inhaler that contains three medications: fluticasone furoate, umeclidinium, and vilanterol. It is used for the long-term treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults. The combination of these medications helps to reduce inflammation, relax airway muscles, and improve breathing by keeping the airways open. Trelegy Ellipta is part of a class of medications known as inhaled corticosteroids, long-acting muscarinic antagonists (LAMAs), and long-acting beta-agonists (LABAs).
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Frequently Asked Questions
How long does it take for Trelegy Ellipta to start working?
Trelegy Ellipta starts to improve breathing within a few hours of the first dose, but it may take several days or weeks to feel the full benefits, especially in asthma patients.
Can I use Trelegy Ellipta for a sudden asthma attack?
No, Trelegy Ellipta is not a rescue inhaler. You should use a fast-acting inhaler, like albuterol, for sudden asthma symptoms.
How should I clean my Trelegy Ellipta inhaler?
You don’t need to wash the inhaler. If the mouthpiece looks dirty, wipe it with a dry tissue. Avoid using water, as it may damage the inhaler.
What should I do if I miss a dose of Trelegy Ellipta?
If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up doses to make up for a missed one.
Is Trelegy Ellipta safe for long-term use?
Yes, Trelegy Ellipta is designed for long-term use to manage asthma and COPD. Your doctor will monitor your condition and make adjustments if needed to ensure it remains safe and effective over time.
Comprehensive Drug Guide
How Does Trelegy Ellipta Work?
- Fluticasone furoate is a corticosteroid that reduces inflammation in the lungs, helping to prevent asthma attacks and worsening COPD symptoms.
- Umeclidinium is a LAMA that works by relaxing the muscles around the airways, helping to keep them open.
- Vilanterol is a LABA that relaxes the smooth muscles in the airways, allowing for easier breathing. Together, these medications help improve lung function, reduce flare-ups, and enhance overall breathing.
Common Dosages
- 100 mcg fluticasone furoate/62.5 mcg umeclidinium/25 mcg vilanterol per inhalation
- 200 mcg fluticasone furoate/62.5 mcg umeclidinium/25 mcg vilanterol per inhalation (for patients with asthma)
Typical Dosing
- The typical dose for both COPD and asthma is one inhalation once daily. Patients should take the medication at the same time each day to maintain consistent levels in their body.
- For asthma, the specific dose may vary depending on the severity of the condition, but the 200/62.5/25 mcg strength is often used for patients who require higher doses of inhaled corticosteroids.
Typical Dosing
FDA Approved Indications
- Long-term maintenance treatment of COPD, including chronic bronchitis and emphysema
- Maintenance treatment of asthma in adults who are not adequately controlled with a combination of inhaled corticosteroids and LABA therapy.
Who Shouldn't Take Trelegy Ellipta?
- Severe hypersensitivity to fluticasone, umeclidinium, vilanterol, or any other component of the inhaler.
- Acute bronchospasm or status asthmaticus, as it is not intended for acute relief of asthma symptoms.
Advice From The Pharmacist
- Take Trelegy Ellipta exactly as prescribed, once daily at the same time each day. Do not use it more than once a day.
- Rinse your mouth with water and spit after using the inhaler to reduce the risk of oral thrush (a fungal infection in the mouth).
- If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. Do not double the dose to make up for a missed one.
- Store the inhaler in a cool, dry place and keep the inhaler closed until ready to use.
Side Effects of Trelegy Ellipta
Common Side Effects
- Cough
- Headache
- Hoarseness or throat irritation
- Upper respiratory tract infections
- Oral thrush (fungal infection)
Uncommon/Severe Side Effects
- Severe allergic reactions (hives, difficulty breathing)
- Worsening asthma symptoms
- Increased risk of pneumonia in patients with COPD
- Cardiovascular effects (e.g., rapid heartbeat or high blood pressure)
Risks and Warnings of Trelegy Ellipta
- Increased Risk of Pneumonia: Trelegy Ellipta can increase the risk of pneumonia, especially in COPD patients. Seek medical attention if you notice symptoms like fever, chills, or chest pain.
- Paradoxical Bronchospasm: In rare cases, inhalers can cause the airways to become more constricted, leading to difficulty breathing. If this happens, stop using Trelegy Ellipta and contact your doctor immediately.
- Cardiovascular Effects: LABAs, including vilanterol, may increase the risk of heart problems, such as irregular heartbeat or high blood pressure. Patients with existing heart conditions should use caution.
- Not for Acute Asthma Attacks: Trelegy Ellipta is not a rescue inhaler. Always have a fast-acting inhaler on hand for sudden breathing problems.
Interactions with Trelegy Ellipta
Common Drug Interactions
- Beta-blockers: These medications can reduce the effectiveness of vilanterol, increasing the risk of asthma or COPD flare-ups.
- Anticholinergic drugs: Using other anticholinergic medications with umeclidinium may increase the risk of side effects like dry mouth and constipation.
- CYP3A4 inhibitors: Strong inhibitors, such as ketoconazole, may increase the levels of fluticasone and vilanterol, potentially leading to more severe side effects.
Alternatives to Trelegy Ellipta
- Symbicort (budesonide/formoterol): Another inhaler that combines a corticosteroid and LABA for treating asthma and COPD.
- Advair (fluticasone/salmeterol): Similar combination inhaler used for asthma and COPD management.
- Breo Ellipta (fluticasone/vilanterol): A two-drug combination (without umeclidinium) used for asthma and COPD treatment.
- Spiriva (tiotropium): A LAMA inhaler used for long-term maintenance of COPD.
