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Tranxene-T
Tranxene-T (clorazepate dipotassium) is a benzodiazepine used for the treatment of anxiety disorders, acute alcohol withdrawal symptoms, and as an adjunctive treatment in seizure disorders. Benzodiazepines like Tranxene-T work by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that induces a calming effect. Tranxene-T is often prescribed to reduce anxiety, manage withdrawal symptoms, and stabilize mood in patients with anxiety or seizure-related conditions.
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Frequently Asked Questions
How long does it take for Tranxene-T to start working?
Tranxene-T begins to work within 30 minutes to 1 hour after taking it, though full effects for anxiety or alcohol withdrawal management may take a few days.
Can Tranxene-T be used long-term?
Tranxene-T is generally prescribed for short-term use due to its potential for dependence. Long-term use should only occur under close medical supervision.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can I stop taking Tranxene-T suddenly?
No, stopping Tranxene-T abruptly can cause withdrawal symptoms, including seizures. Always taper the dose gradually under a doctor’s guidance.
Can Tranxene-T cause memory problems?
Yes, memory impairment is a potential side effect of Tranxene-T, especially with long-term use or high doses. Let your doctor know if you experience any cognitive issues.
Comprehensive Drug Guide
How Does Tranxene-T Work?
Clorazepate, the active ingredient in Tranxene-T, works by increasing the activity of GABA, a neurotransmitter that inhibits nerve signals in the brain. This increased GABA activity produces a calming effect, reducing anxiety, controlling seizures, and helping with the symptoms of alcohol withdrawal.
Common Dosages
- Tablets: 3.75 mg, 7.5 mg, and 15 mg
Typical Dosing
- For anxiety, the typical dose ranges from 7.5 mg to 15 mg per day, which may be divided into two or three doses.
- For acute alcohol withdrawal, initial doses start at 30 mg to 90 mg per day, gradually reduced as symptoms improve.
- For seizures, the dose is adjusted based on the patient’s response and combined with other anticonvulsants.
Typical Dosing
FDA Approved Indications
- Management of anxiety disorders
- Treatment of acute alcohol withdrawal symptoms
- Adjunctive therapy in treating partial seizures or certain types of epilepsy
Who Shouldn't Take Tranxene-T?
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Known hypersensitivity to clorazepate or other benzodiazepines
- Severe liver disease
Advice From The Pharmacist
- Take Tranxene-T exactly as prescribed, without increasing or decreasing the dose without consulting your doctor. Do not stop taking it abruptly, as it can cause withdrawal symptoms.
- Avoid alcohol while taking Tranxene-T, as it can enhance the sedative effects and increase the risk of side effects like drowsiness and dizziness.
- Tranxene-T can be habit-forming, so use it only as directed and for short periods unless otherwise specified by your healthcare provider.
- If using it for alcohol withdrawal, follow your doctor's instructions closely, as the dosage will need to be tapered down over time.
Side Effects of Tranxene-T
Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Blurred vision
- Confusion
Uncommon/Severe Side Effects
- Respiratory depression (slowed or difficult breathing)
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Memory impairment or concentration problems
- Physical dependence or withdrawal symptoms with long-term use
Risks and Warnings of Tranxene-T
- Addiction and Dependence: Tranxene-T can be habit-forming, especially with prolonged use. Take it only as prescribed and discuss any concerns about dependence with your doctor.
- Withdrawal Symptoms: Stopping Tranxene-T abruptly can cause withdrawal symptoms, including anxiety, restlessness, tremors, and seizures. Gradual tapering is recommended under a doctor’s supervision.
- CNS Depression: Combining Tranxene-T with other central nervous system (CNS) depressants, such as alcohol or opioids, can cause severe drowsiness, respiratory depression, or even coma.
Interactions with Tranxene-T
Common Drug Interactions
- Alcohol: Combining Tranxene-T with alcohol increases the risk of severe drowsiness and respiratory depression.
- Opioids: Using Tranxene-T with opioid medications (such as morphine or oxycodone) increases the risk of serious side effects, including profound sedation, respiratory depression, or death.
- Antidepressants: Combining Tranxene-T with certain antidepressants (such as SSRIs or SNRIs) can increase the risk of CNS depression.
- Anticonvulsants: If used with other anticonvulsants, dosage adjustments may be necessary to avoid excessive sedation.
Alternatives to Tranxene-T
- Diazepam (Valium): Another benzodiazepine used for anxiety, alcohol withdrawal, and seizure disorders.
- Lorazepam (Ativan): A benzodiazepine used for anxiety and seizures, offering a shorter duration of action.
- Clonazepam (Klonopin): A long-acting benzodiazepine used for anxiety and seizure disorders.
- Buspirone: A non-benzodiazepine alternative for the treatment of anxiety.
