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Temixys
Temixys is a combination antiretroviral medication used to treat HIV-1 infection in adults and pediatric patients weighing at least 35 kg. It contains two active ingredients: lamivudine and tenofovir disoproxil fumarate (TDF). Both drugs belong to a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs), which work by preventing the HIV virus from multiplying in the body, thus reducing the viral load and helping the immune system function better. Temixys is typically used as part of combination therapy with other antiretrovirals.
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Frequently Asked Questions
How long does it take for Temixys to work?
Temixys starts working to reduce HIV viral load within a few days to weeks. However, it may take several months of consistent use to reach an undetectable viral load.
Can I take Temixys with other HIV medications?
Yes, Temixys is typically used in combination with other antiretroviral drugs to provide a complete HIV treatment regimen. Always follow your doctor's guidance on how to take these medications.
What should I do if I miss a dose of Temixys?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once.
Can Temixys cure HIV?
No, Temixys does not cure HIV, but it helps control the virus, reducing viral load and boosting the immune system. Long-term therapy can allow patients to live healthier lives and reduce the risk of transmission.
Can I take Temixys during pregnancy?
Temixys may be used during pregnancy if the benefits outweigh the risks. Always discuss with your doctor if you are pregnant or planning to become pregnant while on HIV therapy.
Comprehensive Drug Guide
How Does Temixys Work?
Both lamivudine and tenofovir disoproxil fumarate inhibit reverse transcriptase, an enzyme essential for the replication of HIV. By blocking this enzyme, Temixys prevents the virus from multiplying and reduces the amount of HIV in the blood (viral load). This helps improve the immune system's ability to fight infections and reduces the risk of HIV-related complications.
Common Dosages
- 300 mg of lamivudine
- 300 mg of tenofovir disoproxil fumarate
Typical Dosing
- Adults and pediatric patients (weighing at least 35 kg): One tablet taken once daily by mouth, with or without food. Temixys should be used as part of a combination therapy regimen with other antiretroviral medications.
Typical Dosing
FDA Approved Indications
- HIV-1 infection in combination with other antiretroviral agents in adults and pediatric patients weighing at least 35 kg.
Who Shouldn't Take Temixys?
- Known hypersensitivity to lamivudine, tenofovir disoproxil fumarate, or any of the components in the formulation.
- Severe renal impairment or those requiring dialysis (tenofovir can affect kidney function).
Advice From The Pharmacist
- Take Temixys once daily at the same time every day to maintain consistent drug levels in your body.
- Do not stop taking Temixys without consulting your doctor, even if you feel well, as this can lead to viral resistance and a worsening of your condition.
- Regular blood tests will be needed to monitor kidney and liver function, as tenofovir disoproxil fumarate can affect both organs.
- Stay hydrated while taking Temixys, as dehydration can increase the risk of kidney side effects.
- If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and resume your regular schedule. Do not double up doses.
Side Effects of Temixys
Common Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Fatigue
Uncommon/Severe Side Effects
- Lactic acidosis: A rare but serious condition involving the buildup of lactic acid in the blood. Symptoms may include muscle pain, trouble breathing, stomach pain, or weakness.
- Kidney problems: Tenofovir can cause kidney damage, especially in people with pre-existing kidney conditions.
- Bone loss: Long-term use of tenofovir has been associated with decreased bone mineral density, which can increase the risk of fractures.
- Liver problems: Worsening of hepatitis B infection if Temixys is discontinued in patients co-infected with HIV and hepatitis B.
Risks and Warnings of Temixys
- Lactic Acidosis and Hepatomegaly: Temixys can cause lactic acidosis and liver enlargement. Seek immediate medical attention if you experience unusual symptoms like rapid breathing, weakness, or abdominal pain.
- Kidney Function: Regular monitoring of kidney function is necessary, as tenofovir may lead to kidney damage or worsening of pre-existing kidney disease.
- Bone Loss: Long-term use of tenofovir can lead to a decrease in bone mineral density, which can increase the risk of fractures, especially in patients with other risk factors for bone loss.
- Hepatitis B Co-infection: Discontinuation of Temixys in patients co-infected with HIV and hepatitis B can lead to severe worsening of hepatitis B. Your doctor may monitor your liver function closely after stopping Temixys.
Interactions with Temixys
Common Drug Interactions
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Combining Temixys with NSAIDs like ibuprofen may increase the risk of kidney problems.
- HIV Protease Inhibitors: Medications like atazanavir may interact with tenofovir, requiring dose adjustments.
- Hepatitis C medications: Sofosbuvir-based regimens may interact with tenofovir, requiring careful monitoring.
Alternatives to Temixys
- Truvada: A combination of emtricitabine and tenofovir disoproxil fumarate, commonly used for both HIV treatment and PrEP (pre-exposure prophylaxis).
- Descovy: A newer version of Truvada containing tenofovir alafenamide, which has fewer kidney and bone-related side effects.
- Biktarvy: A complete regimen that contains bictegravir, emtricitabine, and tenofovir alafenamide, used for the treatment of HIV-1 infection.
- Epzicom: A combination of abacavir and lamivudine, used for the treatment of HIV infection.
