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Tardeoxia
Tardeoxia is a topical acne treatment that combines three active ingredients: tretinoin, clindamycin, and niacin. This combination helps to treat moderate to severe acne by addressing multiple factors that cause breakouts. Tretinoin is a retinoid that promotes cell turnover, clindamycin is an antibiotic that fights acne-causing bacteria, and niacin (vitamin B3) reduces inflammation and improves skin texture.
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Frequently Asked Questions
How long does it take for Tardeoxia to work?
Improvements in acne may be noticeable after 4 to 8 weeks of consistent use, but full results may take up to 12 weeks. It’s important to continue using the medication as directed, even if your acne worsens initially.
Can I use makeup while using Tardeoxia?
Yes, makeup can be used, but ensure that it is non-comedogenic (won’t clog pores). Apply makeup after Tardeoxia has fully absorbed into the skin.
Can I stop using Tardeoxia once my acne clears up?
It is important to follow your healthcare provider’s instructions. Even after your acne improves, maintenance treatment may be necessary to prevent future breakouts.
Can Tardeoxia cause my acne to get worse before it gets better?
Yes, it’s common to experience initial worsening of acne (known as purging) when starting tretinoin. This is temporary and typically resolves within a few weeks.
Can Tardeoxia be used during pregnancy?
No, Tardeoxia should not be used during pregnancy because tretinoin can increase the risk of birth defects. Consult your healthcare provider if you are pregnant or planning to become pregnant.
Comprehensive Drug Guide
How Does Tardeoxia Work?
- Tretinoin works by increasing the turnover of skin cells, preventing clogged pores, and promoting the removal of dead skin cells, reducing the formation of acne lesions.
- Clindamycin is a topical antibiotic that targets Propionibacterium acnes, the bacteria responsible for causing acne inflammation.
- Niacin (vitamin B3) helps to reduce inflammation, improve skin barrier function, and regulate oil production, further helping to clear acne and improve skin texture.
Common Dosages
- Tretinoin 0.025%
- Clindamycin 1%
- Niacin 4%
Typical Dosing
- For acne: Apply a thin layer of Tardeoxia to the affected areas of the skin once daily, preferably in the evening, after cleansing the face.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe acne in individuals who are unresponsive to monotherapy or other topical treatments.
Who Shouldn't Take Tardeoxia?
- Hypersensitivity to tretinoin, clindamycin, niacin, or any other components of the formulation.
- History of gastrointestinal diseases such as colitis caused by antibiotics (clindamycin can potentially cause colitis).
- Pregnancy: Tretinoin is a Pregnancy Category C drug and should not be used during pregnancy due to the potential risk of birth defects.
Advice From The Pharmacist
- Apply Tardeoxia at night, after washing and drying your face. Avoid applying too much, as this can increase irritation.
- Avoid prolonged sun exposure while using Tardeoxia, as tretinoin can increase your skin's sensitivity to the sun. Use a broad-spectrum sunscreen during the day.
- Do not use other acne treatments (like benzoyl peroxide or salicylic acid) unless directed by your healthcare provider, as this may cause excessive skin irritation.
- Store Tardeoxia at room temperature, away from moisture and direct sunlight.
- If you experience irritation, such as redness, peeling, or burning, reduce the frequency of application or consult your healthcare provider.
Side Effects of Tardeoxia
Common Side Effects
- Skin irritation (redness, peeling, or burning)
- Dryness
- Itching
- Sensitivity to sunlight
Uncommon/Severe Side Effects
- Severe allergic reactions, such as swelling, rash, or difficulty breathing.
- Colitis: Clindamycin may cause gastrointestinal problems, including diarrhea or bloody stools, which can indicate colitis.
Risks and Warnings of Tardeoxia
- Sun Sensitivity: Tretinoin increases skin sensitivity to UV light, increasing the risk of sunburn. Use sunscreen (SPF 30 or higher) daily and wear protective clothing when outdoors.
- Antibiotic Resistance: Prolonged use of clindamycin can lead to bacterial resistance. Follow the prescribed treatment course and do not use this medication longer than recommended.
- Skin Irritation: If excessive dryness, peeling, or irritation occurs, reduce the frequency of application or consult your doctor.
- Gastrointestinal Issues: Clindamycin can cause colitis, which may present as severe diarrhea. If you experience this, stop using the product and contact your healthcare provider immediately.
Interactions with Tardeoxia
Common Drug Interactions
- Other topical acne products: Using other topical products containing benzoyl peroxide, salicylic acid, or retinoids with Tardeoxia may cause excessive skin irritation.
- Photosensitizing agents: Tretinoin can increase sensitivity to light. Avoid medications that also cause sun sensitivity, such as tetracyclines or sulfonamides.
- Systemic antibiotics: Be cautious when using other antibiotics in conjunction with clindamycin to prevent antibiotic resistance or gastrointestinal side effects.
Alternatives to Tardeoxia
- Differin (Adapalene): A topical retinoid available over the counter for acne treatment.
- Benzoyl Peroxide: An over-the-counter antibacterial agent that can help treat acne.
- Tretinoin (Retin-A): A prescription-strength retinoid available for acne treatment.
- Epiduo (Adapalene/Benzoyl Peroxide): Another combination topical treatment for acne.
- Oral antibiotics (e.g., doxycycline, minocycline): Used for more severe acne that does not respond to topical treatments.
