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Epiduo
Epiduo is a topical gel that combines two active ingredients: adapalene (a retinoid) and benzoyl peroxide (an antimicrobial and keratolytic agent). It is used to treat acne vulgaris in patients aged 9 years and older. Adapalene helps to unclog pores and reduce inflammation, while benzoyl peroxide works to kill acne-causing bacteria and exfoliate the skin. Epiduo is particularly effective for mild to moderate acne and can help prevent new acne lesions from forming.
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Frequently Asked Questions
How long does it take for Epiduo to show results?
It can take 4 to 8 weeks to see significant improvement in acne. Some patients may experience worsening of acne during the first few weeks before improvement occurs.
Can I use makeup while using Epiduo?
Yes, you can use non-comedogenic (won’t clog pores) makeup while using Epiduo. Ensure that you remove makeup thoroughly before applying the medication.
What should I do if I experience severe dryness or irritation?
If you experience significant irritation, reduce the frequency of application to every other day or consult your healthcare provider for advice. Using a gentle, non-irritating moisturizer may help alleviate the dryness.
Is Epiduo safe for teenagers?
Yes, Epiduo is approved for use in patients aged 9 years and older, making it suitable for adolescents with acne.
Can Epiduo be used on the body?
Yes, Epiduo can be used on other areas of the body affected by acne, such as the chest and back. Apply a thin layer to the affected areas once daily.
Comprehensive Drug Guide
How Does Epiduo Work?
Epiduo combines two mechanisms to treat acne:
- Adapalene: A retinoid that regulates skin cell turnover, preventing clogged pores and reducing inflammation. It also helps normalize skin shedding, which is essential for treating acne.
- Benzoyl Peroxide: An antimicrobial agent that kills Propionibacterium acnes (acne-causing bacteria) and helps prevent the formation of comedones (clogged pores). It also has a drying and exfoliating effect on the skin.
Common Dosages
Epiduo is available by prescription only and is not classified as a controlled substance. It comes in the following forms:
- Topical gel: 0.1% adapalene / 2.5% benzoyl peroxide
- Epiduo Forte gel: 0.3% adapalene / 2.5% benzoyl peroxide
Typical Dosing
- Apply once daily in the evening. Clean the affected area and gently pat dry before applying a thin layer of Epiduo. Avoid the eyes, lips, and mucous membranes.
Typical Dosing
FDA Approved Indications
- Treatment of acne vulgaris in patients aged 9 years and older
Who Shouldn't Take Epiduo?
- Known hypersensitivity to adapalene, benzoyl peroxide, or any of the product's ingredients
- Severe skin irritation or conditions like eczema
Advice From The Pharmacist
- Use sunscreen during the day, as adapalene can make the skin more sensitive to sunlight.
- Avoid applying Epiduo to broken or irritated skin, and do not use it near the eyes or lips, as this can cause significant irritation.
- Apply moisturizer if you experience dryness, peeling, or irritation during the first few weeks of treatment.
- Do not use harsh skin care products (e.g., scrubs, exfoliants, or products containing alcohol) while using Epiduo, as these may increase irritation.
Side Effects of Epiduo
Common Side Effects
- Dryness
- Redness
- Peeling
- Burning or stinging sensation
- Itching
Uncommon/Severe Side Effects
- Severe skin irritation or allergic reactions (hives, swelling, difficulty breathing)
Risks and Warnings of Epiduo
- Photosensitivity: Adapalene may make the skin more sensitive to sunlight, increasing the risk of sunburn. Sunscreen and protective clothing are recommended.
- Irritation: Benzoyl peroxide can cause skin irritation, especially during the first few weeks of treatment. If severe irritation occurs, reduce the frequency of application or discontinue use.
- Allergic Reactions: While rare, benzoyl peroxide can cause allergic reactions. Discontinue use if signs of an allergic reaction, such as swelling or rash, develop.
Interactions with Epiduo
Common Drug Interactions
- Topical Retinoids or Exfoliants: Using Epiduo with other topical retinoids or exfoliating agents can increase skin irritation.
- Medicated or abrasive soaps: These products can increase the risk of irritation when used alongside Epiduo.
- Salicylic Acid: Using products containing salicylic acid while using Epiduo may increase dryness and peeling.
Alternatives to Epiduo
- Differin Gel (Adapalene): A single-agent retinoid used for acne treatment.
- Benzoyl Peroxide Wash or Gel: Used as a standalone treatment for acne.
- Clindamycin and Benzoyl Peroxide Gel (BenzaClin): Another combination therapy for acne that includes an antibiotic.
- Tretinoin (Retin-A): Another retinoid that is commonly used to treat acne.
