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Stromectol
Stromectol (generic name: ivermectin) is an antiparasitic medication used to treat several parasitic infections in humans, including strongyloidiasis, onchocerciasis (river blindness), and scabies. It works by paralyzing and killing parasites or preventing them from reproducing. In recent years, ivermectin has gained attention for off-label use in the treatment of other conditions, but its approved uses remain focused on parasitic infections.
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Frequently Asked Questions
How long does it take for Stromectol to work?
The effects of Stromectol begin within 1-2 hours after administration, but the full resolution of symptoms may take several days. The exact timing depends on the type of infection being treated.
Can I take Stromectol with food?
It is recommended to take Stromectol on an empty stomach with water. Taking it with food may reduce its absorption and effectiveness.
How often will I need to take Stromectol?
For most parasitic infections, a single dose of Stromectol is sufficient. However, in some cases, especially with onchocerciasis, repeat doses may be required over a period of time.
Is Stromectol safe for children?
Yes, Stromectol can be used in children weighing at least 15 kg. The dose is based on body weight, and pediatric patients should be closely monitored by a healthcare provider.
Can Stromectol be used for COVID-19?
Although ivermectin has been studied for off-label use in the treatment of COVID-19, it is not FDA-approved for this purpose, and its use for COVID-19 remains controversial. Consult your healthcare provider for guidance on appropriate treatments for COVID-19.
Comprehensive Drug Guide
How Does Stromectol Work?
Ivermectin works by binding to glutamate-gated chloride ion channels in the nerve and muscle cells of parasites. This binding increases the permeability of cell membranes to chloride ions, leading to paralysis and death of the parasite. It is effective against a wide variety of parasites, including nematodes (roundworms) and arthropods (mites and lice).
Common Dosages
- 3 mg tablets
Typical Dosing
- For strongyloidiasis: The typical dose is 200 mcg/kg of body weight as a single oral dose.
- For onchocerciasis: The recommended dose is 150 mcg/kg of body weight, taken as a single dose. Repeat doses may be necessary to control the infection.
The dosing regimen may vary depending on the specific infection being treated and the patient's weight.
Typical Dosing
FDA Approved Indications
- Strongyloidiasis of the intestinal tract: A parasitic infection caused by the roundworm Strongyloides stercoralis.
- Onchocerciasis (river blindness): A parasitic infection caused by the filarial worm Onchocerca volvulus.
Additionally, Stromectol is used off-label for conditions such as scabies and head lice, although these uses are not FDA-approved.
Who Shouldn't Take Stromectol?
- Known hypersensitivity to ivermectin or any of the components in Stromectol.
- Severe liver disease: Ivermectin is metabolized in the liver, and caution should be used in patients with significant hepatic impairment.
Advice From The Pharmacist
- Stromectol should be taken on an empty stomach with water to maximize absorption.
- Patients may need repeated doses for certain parasitic infections, so it’s important to follow up with your healthcare provider.
- If you are taking Stromectol for scabies or lice, remember that good personal hygiene and laundering of bedding, clothes, and towels are important in preventing reinfection.
Side Effects of Stromectol
Common Side Effects
- Dizziness
- Nausea or diarrhea
- Headache
- Fatigue or drowsiness
Uncommon/Severe Side Effects
- Neurological effects: In rare cases, patients with heavy parasite loads, particularly in onchocerciasis, may experience Mazzotti reaction (severe immune response), which includes fever, rash, swollen lymph nodes, and eye inflammation.
- Liver problems: Elevated liver enzymes and other signs of liver dysfunction can occur, particularly in patients with pre-existing liver issues.
Risks and Warnings of Stromectol
- Mazzotti Reaction: In patients being treated for onchocerciasis, ivermectin can cause a significant immune response known as the Mazzotti reaction, leading to fever, skin rash, joint pain, and lymph node swelling. This reaction is thought to occur as a result of the body’s response to the death of the parasites.
- Neurotoxicity: Rare cases of neurotoxicity (confusion, ataxia, seizures) have been reported, particularly in patients with high parasite loads.
- Liver Impairment: Since ivermectin is metabolized in the liver, patients with impaired liver function should use Stromectol with caution and under close medical supervision.
Interactions with Stromectol
Common Drug Interactions
- Warfarin: Ivermectin may interact with warfarin and other anticoagulants, potentially increasing the risk of bleeding.
- Other medications: Drugs that affect liver enzymes (CYP3A4 inducers or inhibitors) may influence the metabolism of ivermectin and affect its efficacy or toxicity.
Alternatives to Stromectol
- Albendazole: Another antiparasitic medication used for a variety of parasitic infections, including certain types of roundworm infections.
- Mebendazole: Typically used to treat infections caused by pinworms, whipworms, and hookworms.
- Permethrin: A topical medication used to treat scabies and head lice.
