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Sotyktu
Sotyktu (generic name: deucravacitinib) is an oral medication used to treat moderate to severe plaque psoriasis in adults. It belongs to a class of medications known as TYK2 inhibitors (tyrosine kinase 2 inhibitors). Sotyktu works by selectively inhibiting the TYK2 enzyme, which plays a role in immune signaling pathways involved in inflammation and overactive immune responses that lead to plaque psoriasis. By modulating these immune responses, Sotyktu helps reduce the symptoms of psoriasis, including plaque formation, redness, and scaling.
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Frequently Asked Questions
How long does it take for Sotyktu to start working?
Many patients start to see improvements in their psoriasis symptoms within the first 4 to 6 weeks of treatment, but it may take longer for the full effects to be realized.
Can I take Sotyktu if I have an infection?
If you have an active infection, it is important to inform your healthcare provider before starting Sotyktu. The medication may weaken your immune system, making infections more difficult to treat.
Can I receive vaccinations while on Sotyktu?
Live vaccines should be avoided during treatment with Sotyktu, as the medication can reduce your immune system’s ability to respond to the vaccine. Inactivated vaccines, such as the flu shot, are generally safe.
Can Sotyktu be taken long-term?
Yes, Sotyktu is designed for long-term use in managing moderate to severe plaque psoriasis. Regular monitoring by your healthcare provider is important to ensure the treatment remains safe and effective over time.
What should I do if I miss a dose of Sotyktu?
If you miss a dose, take it as soon as you remember. If it’s close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
Comprehensive Drug Guide
How Does Sotyktu Work?
Sotyktu works by selectively inhibiting TYK2, an enzyme that mediates signaling for cytokines involved in the immune and inflammatory responses, such as interleukin (IL)-12, IL-23, and interferon-alpha. These cytokines are key drivers of the overactive immune response seen in plaque psoriasis. By inhibiting TYK2, Sotyktu reduces inflammation and the excessive skin cell growth that leads to the formation of psoriatic plaques.
Common Dosages
- 6 mg tablets
Typical Dosing
- The recommended dose of Sotyktu is 6 mg taken orally once daily, with or without food. It is important to take the medication consistently at the same time each day.
Typical Dosing
FDA Approved Indications
- Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Who Shouldn't Take Sotyktu?
- Known hypersensitivity to deucravacitinib or any components of the formulation.
- Severe liver disease: Use should be avoided or closely monitored in patients with significant liver impairment.
- Active or untreated infections, such as tuberculosis (TB).
Advice From The Pharmacist
- Take Sotyktu exactly as prescribed by your healthcare provider. Do not stop taking it without consulting your doctor.
- Regular blood tests may be required to monitor liver function and overall health during treatment with Sotyktu.
- Avoid live vaccines during treatment with Sotyktu, as the medication may weaken the immune system’s response to live vaccines.
- Inform your doctor if you develop any signs of infection, such as fever, cough, or fatigue, while taking Sotyktu.
Side Effects of Sotyktu
Common Side Effects
- Upper respiratory infections
- Headache
- Fatigue
- Nausea
- Diarrhea
Uncommon/Severe Side Effects
- Infections: Sotyktu can increase the risk of serious infections, including tuberculosis (TB) and fungal infections.
- Liver enzyme elevation: Some patients may experience increased liver enzymes, indicating liver function issues.
- Severe allergic reactions: Such as rash, swelling, or difficulty breathing.
Risks and Warnings of Sotyktu
- Infection Risk: Sotyktu can weaken the immune system and increase the risk of serious infections, including TB, viral infections, and fungal infections. Patients should be screened for TB before starting treatment, and those with a history of recurrent infections should be monitored closely.
- Liver Function: Sotyktu can cause elevated liver enzymes, indicating potential liver damage. Regular blood tests are recommended to monitor liver health during treatment.
- Hypersensitivity Reactions: Severe allergic reactions, including angioedema and anaphylaxis, may occur. Patients should discontinue use and seek immediate medical attention if they experience symptoms such as swelling, hives, or difficulty breathing.
Interactions with Sotyktu
Common Drug Interactions
- Immunosuppressants: Combining Sotyktu with other immunosuppressive therapies (e.g., biologics or corticosteroids) can increase the risk of infections.
- Live vaccines: Live vaccines should be avoided during treatment with Sotyktu due to the risk of weakened immune response.
Alternatives to Sotyktu
- Otezla (apremilast): An oral medication used to treat psoriasis and psoriatic arthritis, though it works by inhibiting phosphodiesterase-4 (PDE4) rather than TYK2.
- Biologic therapies: Such as Humira (adalimumab), Stelara (ustekinumab), and Cosentyx (secukinumab), which are used for moderate to severe plaque psoriasis but administered via injection.
- Methotrexate: A traditional disease-modifying antirheumatic drug (DMARD) that may be used for moderate to severe psoriasis but carries a risk of more serious side effects.
- Phototherapy: Ultraviolet (UV) light treatment can also be used for moderate to severe plaque psoriasis, particularly in patients who do not respond well to oral or injectable therapies.
