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Soliqua
Soliqua (insulin glargine and lixisenatide) is a combination medication used for the treatment of type 2 diabetes in adults. It combines insulin glargine, a long-acting insulin, with lixisenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist. This combination helps to lower blood sugar levels by enhancing insulin secretion, reducing glucose production by the liver, and slowing gastric emptying, thereby improving overall glycemic control.
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Frequently Asked Questions
How long does it take for Soliqua to start working?
Soliqua generally starts to work within a few hours, with maximum effects seen over time as it provides sustained glucose control.
Can I stop taking Soliqua suddenly?
No, it is important to consult your healthcare provider before stopping Soliqua to avoid worsening blood sugar control.
Is Soliqua safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding, as the safety of Soliqua during these periods should be evaluated on a case-by-case basis.
What should I do if I miss a dose of Soliqua?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Soliqua?
Maintain a balanced diet and monitor carbohydrate intake, as this will help in managing blood sugar levels effectively. Always follow your healthcare provider's dietary recommendations.
Comprehensive Drug Guide
How Does Soliqua Work?
Insulin glargine provides a steady release of insulin that helps to lower blood glucose levels by facilitating glucose uptake in tissues and inhibiting glucose production by the liver. Lixisenatide enhances insulin secretion in response to meals, reduces glucagon secretion, and delays gastric emptying. Together, these actions help to improve glycemic control in patients with type 2 diabetes.
Common Dosages
- Pre-filled Pens: Each pen contains either 100 units/mL of insulin glargine and 33 mcg/mL of lixisenatide.
Typical Dosing
- For adults with type 2 diabetes: The recommended starting dose is 15 units of Soliqua once daily. The dose may be adjusted based on individual blood glucose levels, with a maximum dose of 60 units per day.
Typical Dosing
FDA Approved Indications
- Treatment of type 2 diabetes in adults to improve glycemic control in combination with diet and exercise.
Who Shouldn't Take Soliqua?
- Known hypersensitivity to insulin glargine, lixisenatide, or any components of the formulation.
- History of severe hypoglycemia.
- Gastroparesis or other significant gastrointestinal disorders.
Advice From The Pharmacist
- Take Soliqua exactly as prescribed by your healthcare provider. It is usually administered once daily, preferably at the same time each day.
- Rotate injection sites to reduce the risk of lipodystrophy (abnormal fat distribution).
- Monitor blood glucose levels regularly and report any significant changes to your healthcare provider.
- Be aware of signs of hypoglycemia (low blood sugar), such as sweating, dizziness, or confusion, and have a source of fast-acting glucose available.
Side Effects of Soliqua
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Injection site reactions (redness, itching, swelling)
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling, difficulty breathing)
- Pancreatitis (severe abdominal pain)
- Hypoglycemia
Risks and Warnings of Soliqua
- Hypoglycemia Risk: There is a risk of low blood sugar, especially if Soliqua is used in conjunction with other antidiabetic medications. Close monitoring is essential.
- Pancreatitis Risk: Patients should be monitored for signs of pancreatitis, which may require discontinuation of the medication.
Interactions with Soliqua
Common Drug Interactions
- Other Antidiabetic Medications: Be cautious when combining Soliqua with other diabetes medications, as this may increase the risk of hypoglycemia.
- Alcohol: Use of alcohol may increase the risk of hypoglycemia; patients should be advised to drink alcohol in moderation and to monitor blood glucose levels accordingly.
Alternatives to Soliqua
- Other Insulin Therapies: Alternatives include insulin detemir, insulin aspart, or other insulin formulations for managing type 2 diabetes.
- GLP-1 Receptor Agonists: Such as exenatide or liraglutide, can also be used for similar indications.
