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Skyclarys
Skyclarys (aprimilast) is a phosphodiesterase 4 (PDE4) inhibitor primarily prescribed for the treatment of palmoplantar psoriasis and oral ulcers associated with Behçet's disease. By modulating the immune response, it helps reduce inflammation and improve skin and mucosal symptoms. Skyclarys offers a targeted approach to managing chronic conditions by focusing on the underlying mechanisms of inflammation.
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Frequently Asked Questions
How long does it take for Skyclarys to start working?
Many patients may begin to see improvements within the first few weeks of treatment, but optimal results may take several months.
Can I take Skyclarys with other medications?
Always consult your healthcare provider before combining Skyclarys with other medications to avoid potential interactions.
What should I do if I miss a dose of Skyclarys?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Skyclarys?
There are no specific dietary restrictions, but maintaining a balanced diet can help manage any gastrointestinal side effects.
Is Skyclarys safe for long-term use?
Skyclarys has been shown to be safe for long-term use, but regular check-ins with your healthcare provider are essential to monitor your response and any potential side effects.
Comprehensive Drug Guide
How Does Skyclarys Work?
Skyclarys works by inhibiting the enzyme phosphodiesterase 4 (PDE4), which plays a key role in the inflammatory pathway. By blocking PDE4, Skyclarys increases the levels of cyclic adenosine monophosphate (cAMP) in immune cells, leading to a decrease in pro-inflammatory cytokines. This action helps alleviate symptoms of inflammation and improves skin and mucosal health.
Common Dosages
- Tablets: 10 mg and 20 mg dosages.
Typical Dosing
- For palmoplantar psoriasis: The usual starting dose is 10 mg once daily, which may be adjusted to 20 mg once daily based on the patient's response and tolerance.
- For oral ulcers in Behçet's disease: The recommended dosage is typically 20 mg once daily.
Typical Dosing
FDA Approved Indications
- Palmoplantar psoriasis
- Oral ulcers associated with Behçet's disease
Who Shouldn't Take Skyclarys?
- Known hypersensitivity to aprimilast or any components of the formulation.
- Active gastrointestinal disorders, particularly those that could lead to severe diarrhea.
Advice From The Pharmacist
- Take Skyclarys exactly as prescribed by your healthcare provider. It can be taken with or without food, but consistency in how it is taken is essential.
- Monitor for any gastrointestinal side effects, especially during the initial treatment period. Discuss any concerns with your healthcare provider.
- Inform your healthcare provider about any other medications you are taking to avoid potential interactions.
- Store Skyclarys at room temperature, away from moisture and heat.
Side Effects of Skyclarys
Common Side Effects
- Nausea
- Diarrhea
- Headache
- Upper respiratory infections
Uncommon/Severe Side Effects
- Severe allergic reactions
- Symptoms of depression or suicidal thoughts
Risks and Warnings of Skyclarys
- Gastrointestinal Effects: Skyclarys may cause gastrointestinal symptoms, including diarrhea and nausea, especially during the initial phase of treatment. Patients should be monitored for these effects.
- Mood Changes: Patients with a history of mood disorders should be closely monitored for any worsening symptoms while taking Skyclarys.
Interactions with Skyclarys
Common Drug Interactions
- Other Immunosuppressants: Use with caution when taken alongside other immunomodulatory agents, as this may increase the risk of infections.
- Medications Metabolized by CYP450: Skyclarys may interact with other drugs metabolized by the CYP450 system; always inform your healthcare provider of all medications you are taking.
Alternatives to Skyclarys
- Apremilast (brand name Otezla): Similar mechanism for managing psoriasis and other inflammatory conditions.
- Biologics: Other biologics for psoriasis and Behçet’s disease may include secukinumab (Cosentyx) and ustekinumab (Stelara).
- Traditional DMARDs: Medications like methotrexate may also be considered for similar inflammatory conditions.
