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Sitavig
Sitavig (acyclovir) is an antiviral medication used to treat cold sores (herpes labialis) caused by the herpes simplex virus. It is a buccal tablet that is placed inside the mouth against the gum, allowing the medication to dissolve slowly and directly target the area affected by the virus. Sitavig is effective in reducing the severity and duration of cold sore outbreaks when used at the first sign of symptoms.
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Frequently Asked Questions
How quickly does Sitavig start working?
Sitavig works best when taken at the first sign of a cold sore outbreak, and many patients notice improvements within a few days.
Can I use Sitavig if I am pregnant or breastfeeding?
Consult your healthcare provider before using Sitavig if you are pregnant or breastfeeding, as safety during these times has not been fully established.
What should I do if I miss a dose of Sitavig?
If you miss applying the tablet at the first sign of symptoms, you can still use it later, but it may be less effective. Apply it as soon as you remember.
Can Sitavig be used for other herpes infections?
Sitavig is specifically indicated for cold sores. Other formulations of acyclovir are used for different herpes virus infections, including genital herpes and shingles.
How should I store Sitavig?
Store Sitavig at room temperature, away from moisture and heat, and keep it out of reach of children.
Comprehensive Drug Guide
How Does Sitavig Work?
Sitavig works by inhibiting the replication of the herpes simplex virus. Acyclovir is converted into an active form within the infected cells, where it interferes with viral DNA synthesis, ultimately preventing the virus from multiplying. This action helps to alleviate the symptoms of cold sores and speeds up healing.
Common Dosages
- Buccal Tablet: 50 mg of acyclovir, designed to dissolve in the mouth.
Typical Dosing
- For cold sores: Apply one Sitavig buccal tablet as soon as symptoms (such as tingling or itching) occur. The tablet should be placed in the upper gum region and left in place for at least 6 hours, allowing it to dissolve.
Typical Dosing
FDA Approved Indications
- Treatment of recurrent herpes labialis (cold sores) in adults and adolescents aged 12 years and older.
Who Shouldn't Take Sitavig?
- Known hypersensitivity to acyclovir or any components of the formulation.
- Severe renal impairment; dosage adjustments may be necessary in patients with kidney problems.
Advice From The Pharmacist
- Sitavig is most effective when taken at the first sign of a cold sore outbreak. Monitor for symptoms such as tingling, itching, or redness.
- Avoid eating or drinking for at least 1 hour after placing the tablet to ensure optimal absorption.
- Maintain good hygiene to prevent the spread of the herpes virus to other areas or individuals.
- Consult your healthcare provider if you have any underlying health conditions or are taking other medications that may interact with acyclovir.
Side Effects of Sitavig
Common Side Effects
- Local irritation at the application site
- Nausea
- Diarrhea
- Headache
Uncommon/Severe Side Effects
- Allergic reactions, including rash or difficulty breathing
- Renal toxicity, particularly in patients with preexisting kidney issues
Risks and Warnings of Sitavig
- Renal Impairment: Caution is advised in patients with renal impairment, as acyclovir can accumulate and lead to potential kidney damage.
- Hydration: Ensure adequate hydration while using Sitavig, as dehydration can increase the risk of kidney problems associated with acyclovir.
Interactions with Sitavig
Common Drug Interactions
- Probenecid: This medication may decrease the elimination of acyclovir, increasing the risk of toxicity.
- Other Nephrotoxic Drugs: Use caution when combining Sitavig with other medications that can affect kidney function.
Alternatives to Sitavig
- Oral Acyclovir: Available in tablet form for treating cold sores and other herpes virus-related infections.
- Valacyclovir: Another antiviral that is often used for the treatment of herpes infections and is taken orally.
- Topical Antivirals: Creams such as docosanol may also be used to treat cold sores.
