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Seglentis
Seglentis is a combination medication containing celecoxib (a nonsteroidal anti-inflammatory drug, or NSAID) and tramadol hydrochloride (an opioid analgesic). It is used to treat acute pain in adults. Celecoxib works by reducing inflammation, swelling, and pain, while tramadol affects certain receptors in the brain to alter how the body perceives pain. This combination provides effective pain relief for moderate to severe acute pain, typically after surgery or injury.
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Frequently Asked Questions
How long does it take for Seglentis to start working?
Seglentis typically begins to relieve pain within 1 to 2 hours after taking the dose, providing both anti-inflammatory and pain-relief benefits.
Can Seglentis cause dependence?
Yes, Seglentis contains tramadol, an opioid that carries the risk of dependence and misuse. It should only be used for short-term pain relief and under close supervision.
Can I drink alcohol while taking Seglentis?
No, it is important to avoid alcohol while taking Seglentis, as it can increase the risk of dangerous side effects such as respiratory depression and overdose.
Can I drink alcohol while taking Seglentis?
No, it is important to avoid alcohol while taking Seglentis, as it can increase the risk of dangerous side effects such as respiratory depression and overdose.
What should I do if I miss a dose of Seglentis?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
How long can I take Seglentis?
Seglentis is intended for short-term use in managing acute pain. Prolonged use can increase the risk of side effects such as opioid dependence and gastrointestinal issues. Always follow your healthcare provider's instructions.
Comprehensive Drug Guide
How Does Seglentis Work?
- Celecoxib: An NSAID that works by selectively inhibiting the COX-2 enzyme, reducing the production of prostaglandins, which are chemicals that cause inflammation and pain.
- Tramadol: An opioid that binds to the mu-opioid receptors in the brain to reduce the perception of pain. It also inhibits the reuptake of norepinephrine and serotonin, contributing to its pain-relieving effects.
This combination allows for effective pain relief by targeting both inflammation (through celecoxib) and altering pain perception (through tramadol).
Common Dosages
- 56 mg celecoxib / 44 mg tramadol hydrochloride per tablet.
Typical Dosing
- The recommended dose of Seglentis is 1 or 2 tablets every 12 hours, depending on the severity of pain.
- The maximum daily dose is 4 tablets (224 mg tramadol and 224 mg celecoxib).
- Seglentis should be used for short-term management of acute pain and not for extended periods of time.
Typical Dosing
FDA Approved Indications
- Management of acute pain in adults.
Who Shouldn't Take Seglentis?
- Hypersensitivity to tramadol, celecoxib, or other NSAIDs.
- Severe respiratory depression, as tramadol can worsen this condition.
- Asthma or aspirin-sensitive asthma, as NSAIDs can trigger bronchospasm.
- Gastrointestinal bleeding, as NSAIDs can increase the risk of bleeding.
- Severe liver or kidney impairment.
- History of opioid addiction or misuse.
Advice From The Pharmacist
- Take Seglentis exactly as prescribed. Do not take more than the recommended dose, as tramadol is an opioid that can lead to misuse or overdose.
- Avoid alcohol and other central nervous system depressants (e.g., benzodiazepines), as these can increase the risk of severe side effects, including respiratory depression.
- Do not drive or operate heavy machinery while taking Seglentis, as it can cause drowsiness, dizziness, and impair your ability to react.
- Take Seglentis with food if it causes stomach upset, as NSAIDs can irritate the gastrointestinal tract.
- Monitor for signs of opioid dependence or misuse, especially with long-term use.
- Do not stop taking Seglentis abruptly if you have been using it for an extended period, as tramadol can cause withdrawal symptoms. Consult your healthcare provider for proper tapering if needed.
Side Effects of Seglentis
Common Side Effects
- Nausea or vomiting
- Drowsiness
- Dizziness or lightheadedness
- Constipation
- Stomach pain or indigestion
Uncommon/Severe Side Effects
- Respiratory depression, particularly when taken in higher doses or combined with other depressants.
- Severe gastrointestinal bleeding: NSAIDs like celecoxib can cause ulcers or bleeding, especially in long-term use.
- Opioid misuse or dependence: Tramadol carries a risk of addiction and abuse.
- Allergic reactions: Rash, itching, swelling, or difficulty breathing.
- Serotonin syndrome: A potentially life-threatening condition when taken with certain medications that affect serotonin levels.
Risks and Warnings of Seglentis
- Respiratory depression: The opioid component (tramadol) can cause slowed or difficulty breathing, especially when taken with alcohol, sedatives, or in higher doses. Patients with respiratory conditions should use this medication cautiously.
- Opioid misuse and addiction: Tramadol, like other opioids, carries the risk of misuse, addiction, and dependence. It should be used cautiously and only for short-term pain relief.
- Gastrointestinal bleeding: NSAIDs like celecoxib can cause stomach or intestinal bleeding, especially in older adults or those with a history of ulcers.
- Seizures: Tramadol can lower the seizure threshold, increasing the risk of seizures in certain individuals, particularly those with a history of seizures or taking medications that lower the seizure threshold.
Interactions with Seglentis
Common Drug Interactions
- Alcohol and CNS depressants: Combining Seglentis with alcohol, benzodiazepines, or other CNS depressants can increase the risk of respiratory depression, sedation, and overdose.
- Serotonergic drugs: Taking Seglentis with medications that affect serotonin levels (e.g., SSRIs, SNRIs, MAO inhibitors) can increase the risk of serotonin syndrome.
- Blood thinners: NSAIDs can increase the risk of bleeding when taken with blood-thinning medications (e.g., warfarin).
- Antidepressants: Some antidepressants may interact with tramadol, increasing the risk of seizures or serotonin syndrome.
Alternatives to Seglentis
- Ultram (tramadol): A standalone opioid analgesic used to treat moderate to severe pain.
- Celebrex (celecoxib): A standalone NSAID used to manage pain and inflammation in conditions such as arthritis.
- Norco (hydrocodone/acetaminophen): A combination opioid analgesic and acetaminophen for moderate to severe pain.
- Ibuprofen: An NSAID commonly used for mild to moderate pain relief and inflammation.
