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Rotarix
Rotarix is an oral vaccine used to prevent rotavirus infection, a common cause of severe diarrhea, vomiting, and dehydration in infants and young children. Rotavirus can lead to serious complications, including hospitalization, especially in infants. Rotarix is a live, attenuated vaccine that helps the immune system develop protection against rotavirus by exposing the body to a weakened form of the virus, which does not cause disease but prompts an immune response.
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Frequently Asked Questions
How effective is Rotarix?
Rotarix is highly effective in preventing severe rotavirus gastroenteritis. Clinical studies show that it provides 90-100% protection against severe cases of rotavirus infection.
Can my baby still get rotavirus after receiving Rotarix?
While Rotarix significantly reduces the risk of severe rotavirus infection, it does not provide 100% protection. Your baby may still contract rotavirus, but the symptoms are likely to be much milder.
What should I do if my baby spits up the vaccine?
If your baby spits up or regurgitates a portion of the vaccine, it is generally not necessary to repeat the dose. However, consult your healthcare provider if you are concerned or if the baby spits up a significant amount.
Can Rotarix be given with other vaccines?
Yes, Rotarix can be administered alongside other routine childhood vaccines, such as those for polio, diphtheria, tetanus, and pertussis (DTaP).
What should I do if my baby shows signs of intussusception?
Intussusception is rare but serious. If your baby experiences symptoms such as severe abdominal pain, vomiting, or bloody stools, seek immediate medical attention.
Comprehensive Drug Guide
How Does Rotarix Work?
Rotarix contains a live, weakened form of the rotavirus. When administered orally, the vaccine mimics a natural infection, stimulating the body’s immune system to produce antibodies against rotavirus. These antibodies help the body fight off future infections, reducing the likelihood and severity of illness if the child is exposed to the actual virus.
Common Dosages
- First dose: Administered at 6 weeks of age.
- Second dose: Administered at 4 months of age (at least 4 weeks after the first dose).
Each dose consists of a single oral administration of the vaccine. The full immunization series consists of two doses.
Typical Dosing
- The typical Rotarix vaccination schedule consists of two doses:
- First dose: Given at 6 weeks to 14 weeks of age.
- Second dose: Given at 4 months of age, but no later than 24 weeks of age.
The vaccine is administered orally and should not be given after 24 weeks of age due to the risk of incomplete immunization and other potential complications.
Typical Dosing
FDA Approved Indications
- Prevention of rotavirus gastroenteritis caused by rotavirus in infants and young children. It is typically given to infants starting at 6 weeks of age as part of their routine immunization schedule.
Who Shouldn't Take Rotarix?
- Severe allergic reactions (anaphylaxis) to any of the vaccine components, including latex.
- Severe combined immunodeficiency (SCID), as live vaccines can cause serious illness in individuals with severely weakened immune systems.
- A history of intussusception, a condition in which part of the intestine slides into an adjacent part, which can be life-threatening.
Advice From The Pharmacist
- Ensure your infant receives both doses of Rotarix to provide full protection against rotavirus. Missing doses may reduce the effectiveness of the vaccine.
- Report any signs of intussusception, such as severe stomach pain, vomiting, or bloody stools, to your healthcare provider immediately.
- Do not delay the vaccination schedule. The first dose of Rotarix should be given before 15 weeks of age, and the second dose before 24 weeks.
- The vaccine is administered orally, and infants may spit up some of the dose. If significant amounts are spit up, consult your healthcare provider for advice on whether the dose needs to be repeated.
Side Effects of Rotarix
Common Side Effects
- Irritability or fussiness
- Diarrhea
- Vomiting
- Fever
- Cough or runny nose
Uncommon/Severe Side Effects
- Intussusception: This is a rare but serious condition where part of the intestine folds into itself, causing a blockage. Symptoms may include severe abdominal pain, vomiting, and bloody stools.
- Severe allergic reactions: Symptoms include rash, itching, swelling, and difficulty breathing.
Risks and Warnings of Rotarix
- Intussusception: Infants receiving Rotarix have a small increased risk of intussusception. Parents should monitor for symptoms such as vomiting, bloody stools, or severe abdominal pain, especially in the weeks following vaccination.
- Immune system suppression: Infants with compromised immune systems, such as those with Severe Combined Immunodeficiency (SCID) or other immune disorders, should not receive live vaccines, including Rotarix.
- Shedding of the vaccine virus: The weakened virus in Rotarix may be shed in the infant’s stools for several weeks after vaccination. Caregivers should use good hygiene practices, such as thorough handwashing, when changing diapers to avoid spreading the virus, particularly to individuals with weakened immune systems.
Interactions with Rotarix
Common Drug Interactions
- Other live vaccines: Rotarix can be given at the same time as other routine vaccinations, but consult your healthcare provider if your infant has received any other live vaccines recently.
- Immunosuppressive medications: Infants on immunosuppressive treatments may not respond well to live vaccines and could be at increased risk of complications.
Alternatives to Rotarix
- RotaTeq: Another oral live attenuated vaccine used for the prevention of rotavirus infection. Unlike Rotarix, RotaTeq requires three doses instead of two.
