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Retrovir
Retrovir, also known as Zidovudine, belongs to a class of medication known as nucleoside reverse transcriptase inhibitors (NRTIs). It's primarily used in the treatment of HIV, working to slow down the progression of the virus in the body. Common side effects may include nausea, headache, or changes in the shape or location of body fat. However, your doctor will help you navigate these side effects, to improve your quality of life.
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Frequently Asked Questions
Can I just stop taking Retrovir after I feel better?
It's crucial to take Retrovir as long as your doctor prescribes it, even if you feel better. HIV/AIDS is a lifelong condition, and stopping treatment can lead to the virus becoming resistant to medication.
Can I take Retrovir if I am pregnant?
It's crucial to have detailed discussions with your doctor. The decision depends on your specific situation and the potential benefits and risks.
Does Retrovir have any effect on contraception?
No, Retrovir does not impact the effectiveness of contraceptive pills.
I missed a dose of Retrovir, what should I do?
If it's nearly time for the next dose, then skip the missed one. Otherwise, take it as soon as you remember. But remember, do not double up!
Comprehensive Drug Guide
How Does Retrovir Work?
Retrovir is an antiretroviral drug that inhibits the activity of an enzyme called reverse transcriptase, which the HIV needs to reproduce. By doing this, it slows down the spread of HIV in the body.
What is Retrovir Used For?
FDA indications: Retrovir is used in combination with other antiretroviral agents for the treatment of HIV1 infection. It is also used for the prevention of maternalfetal HIV transmission.
Offlabel uses: There's no generally accepted offlabel use for Retrovir.
Common Dosages
Tablets: 100mg, 300mg
Oral solution: 50mg/5mL
Typical Dosing
FDA Approved Indications
- HIV1 Infection: 600mg per day either in divided doses or as a single dose
- Prevention of MaternalFetal HIV Transmission: Mothers are typically given 100mg 5 times per day until the start of labor
Off-Label Uses
- For offlabel uses: No offlabel dosing guidelines.
Who Shouldn't Take Retrovir?
- Have a known hypersensitivity to Retrovir or any of its components.
- Have low white blood cell levels.
- Have anemia or bone marrow problems.
- Are pregnant, planning to become pregnant, or breastfeeding without the advice of a healthcare provider.
- Have liver disease or hepatitis, as Retrovir can potentially exacerbate these conditions.
- Have kidney disease, as dosage adjustment might be necessary.
Advice From The Pharmacist
- Remember to take Retrovir consistently.
- Do not stop taking Retrovir even if you feel better. HIV/AIDS is a lifelong disease and requires continuous medication.
- Retrovir does not cure HIV or AIDS, but it can significantly improve your quality of life by managing symptoms and slowing the progression of the disease.
- Regular blood tests will be required to monitor your response to the medication and to monitor for side effects.
- Keep all doctor's appointments for regular screenings and checkups.
- Staying hydrated, and maintaining good hydration can help alleviate some side effects.
- Make sure to notify your healthcare provider if you experience unusual tiredness, breathlessness, rapid heartbeat, or pale skin.
Side Effects of Retrovir
Common Side Effects
- Common side effects:
- You might experience nausea or vomiting.
- You may have headaches.
- Weight loss or changes in the shape or location of body fat may occur.
- Severe side effects:
- Chest pain.
- Severe nausea and vomiting.
- Rapid or irregular heartbeat.
- Seizures.
- Signs of a severe allergic reaction like rash, itching or swelling of the face/tongue/throat, severe dizziness, or trouble breathing need immediate medical attention.
Risks and Warnings of Retrovir
- Retrovir may significantly affect the blood cells and can lead to anemia or neutropenia. Regular blood tests are mandatory to monitor these conditions.
- Longterm use of Retrovir can potentially lead to muscle pain or weakness, hence it should be used cautiously in patients with a history of muscle disorders.
- Patients with a history of liver diseases, hepatitis, or alcohol abuse might be at a higher risk of liver damage while using Retrovir. If you have such a history, regular liver function tests are required.
- Women who are pregnant or planning to become pregnant should consult their healthcare providers before initiating Retrovir.
- Retrovir might increase the risk of lactic acidosis or pancreatitis, so use it cautiously if you have a history of these conditions.
Interactions with Retrovir
Common Drug Interactions
- Ganciclovir
- Valganciclovir
- Interferon
- Probenecid
- Ribavirin
Alternatives to Retrovir
- Abacavir
- Tenofovir
- Lamivudine
- Emtricitabine
- Didanosine