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Relexxii
Relexxii (sagopilone) is an antidepressant and anti-anxiety medication used primarily for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD). It belongs to a class of medications known as serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of serotonin and norepinephrine in the brain, helping to improve mood and alleviate anxiety.
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Frequently Asked Questions
How quickly does Relexxii start to work?
Patients may begin to notice improvements in mood and anxiety within 1 to 2 weeks, but it may take several weeks to achieve the full therapeutic effects.
Can I stop taking Relexxii suddenly?
It is not advisable to stop taking Relexxii abruptly without consulting your healthcare provider, as this can lead to withdrawal symptoms or a relapse in symptoms.
Are there any specific dietary restrictions while taking Relexxii?
There are no specific dietary restrictions associated with Relexxii, but patients should avoid excessive alcohol consumption.
What should I do if I miss a dose of Relexxii?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Relexxii safe for long-term use?
Relexxii can be used long-term under medical supervision. Regular follow-ups are important to monitor effectiveness and any potential side effects, particularly for mood and suicidal ideation.
Comprehensive Drug Guide
How Does Relexxii Work?
Sagopilone works by inhibiting the reuptake of serotonin and norepinephrine in the brain, which increases the concentrations of these neurotransmitters in the synaptic cleft. This action contributes to improved mood and reduced feelings of anxiety.
What is Relexxii Used For?
Common Dosages
- Tablets: Common strengths include 75 mg and 150 mg.
Typical Dosing
- The usual recommended starting dose for adults is 75 mg taken orally once daily, which may be increased to 150 mg based on the patient's response and tolerability.
Typical Dosing
FDA Approved Indications
- Major depressive disorder (MDD).
- Generalized anxiety disorder (GAD).
Who Shouldn't Take Relexxii?
- Known hypersensitivity to sagopilone or any components of the formulation.
- Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI.
Advice From The Pharmacist
- Instruct patients to take Relexxii exactly as prescribed and to not discontinue the medication abruptly without consulting their healthcare provider.
- Advise patients about the potential for sedation or drowsiness and caution them against activities requiring alertness, such as driving.
- Encourage patients to monitor their mood and report any changes, including increased anxiety or suicidal thoughts, especially during the first few weeks of treatment.
Side Effects of Relexxii
Common Side Effects
- Nausea
- Dizziness
- Fatigue
- Dry mouth
- Sleep disturbances
Uncommon/Severe Side Effects
- Increased risk of suicidal thoughts or actions, particularly in young adults and adolescents.
- Serotonin syndrome (symptoms may include agitation, hallucinations, fever, sweating, tremors, or muscle rigidity).
Risks and Warnings of Relexxii
- Suicidal Thoughts: Monitor patients for worsening depression or suicidal thoughts, particularly during the initial weeks of treatment or during dose adjustments.
- Serotonin Syndrome: Be aware of the symptoms of serotonin syndrome, especially when starting or increasing doses, or when combined with other serotonergic agents.
Interactions with Relexxii
Common Drug Interactions
- MAO Inhibitors: The combination can lead to serious and potentially fatal reactions; a minimum of 14 days should be allowed between stopping an MAOI and starting Relexxii.
- Other Antidepressants: Caution should be exercised when combining with other antidepressants to avoid additive serotonergic effects.
Alternatives to Relexxii
- Other Antidepressants: Such as SSRIs (e.g., fluoxetine or sertraline) may be considered for similar indications based on individual patient response and tolerability.
- Non-pharmacological Options: Such as cognitive-behavioral therapy (CBT) or other forms of psychotherapy, can also be effective in managing depression and anxiety disorders.
