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Rasagiline Mesylate
Rasagiline Mesylate is a medication used to treat Parkinson’s disease. It belongs to the class of monoamine oxidase-B (MAO-B) inhibitors, which help increase the levels of dopamine in the brain, improving symptoms such as tremors, stiffness, and slowness of movement. It is often used as monotherapy in early Parkinson’s disease or in combination with other medications like levodopa in more advanced stages of the disease.
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Frequently Asked Questions
How long does it take for Rasagiline to start working?
It may take a few weeks for Rasagiline to show significant improvement in Parkinson’s symptoms.
Can Rasagiline be taken with other Parkinson’s medications?
Yes, Rasagiline is often used alongside other medications like levodopa to help manage symptoms in advanced stages of Parkinson’s disease.
Can I eat cheese or cured meats while taking Rasagiline?
Although Rasagiline has a lower risk of tyramine interaction than older MAO inhibitors, it is still wise to avoid large amounts of tyramine-rich foods, such as aged cheeses and cured meats, to reduce the risk of high blood pressure.
What should I do if I miss a dose?
Take the missed dose as soon as you remember unless it is close to your next dose. Do not double up on doses to make up for the missed one.
Does Rasagiline affect blood pressure?
Yes, Rasagiline can cause low blood pressure (orthostatic hypotension), especially when standing up. Rise slowly from sitting or lying positions to avoid dizziness.
Comprehensive Drug Guide
How Does Rasagiline Mesylate Work?
Rasagiline works by inhibiting the monoamine oxidase-B enzyme. This enzyme breaks down dopamine in the brain. By inhibiting this enzyme, Rasagiline increases dopamine levels, which helps improve motor symptoms in Parkinson’s disease.
Common Dosages
- 1 mg tablets
Typical Dosing
- The usual dose is 1 mg once daily, taken with or without food. For patients who experience side effects, the dose may be reduced or adjusted based on the physician’s recommendations.
Typical Dosing
FDA Approved Indications
- Parkinson’s disease as monotherapy or as an adjunct to levodopa
Who Shouldn't Take Rasagiline Mesylate?
- Severe liver impairment
- Concurrent use of certain antidepressants (e.g., SSRIs, SNRIs) or other MAO inhibitors
- Hypersensitivity to rasagiline or its components
Advice From The Pharmacist
- Take Rasagiline exactly as prescribed, once daily, with or without food.
- Avoid foods high in tyramine (e.g., aged cheese, cured meats) as these can increase blood pressure in some people on MAO inhibitors.
- Be cautious when using over-the-counter cold or allergy medications, as they can interact with Rasagiline.
- Contact your healthcare provider if you experience hallucinations, uncontrolled muscle movements, or changes in behavior, especially if you’re also taking levodopa.
Side Effects of Rasagiline Mesylate
Common Side Effects
- Headache
- Dizziness
- Nausea
- Joint pain
Uncommon/Severe Side Effects
- Hypertensive crisis (severe increase in blood pressure)
- Serotonin syndrome (especially if combined with other serotonergic drugs)
- Hallucinations
Risks and Warnings of Rasagiline Mesylate
- Tyramine Interaction: Although rasagiline is a selective MAO-B inhibitor, high amounts of tyramine in the diet may still pose a risk of hypertensive crisis. Be cautious with foods like aged cheeses, cured meats, and certain alcoholic beverages.
- Serotonin Syndrome: Combining Rasagiline with certain antidepressants or serotonergic drugs can lead to serotonin syndrome, a potentially life-threatening condition characterized by high fever, agitation, and tremors.
- Orthostatic Hypotension: Rasagiline can cause low blood pressure when standing, so patients should rise slowly from a seated or lying position.
Interactions with Rasagiline Mesylate
Common Drug Interactions
- Antidepressants (SSRIs, SNRIs): Increases the risk of serotonin syndrome.
- Meperidine: Should not be used due to the risk of severe reactions.
- Dextromethorphan: Risk of severe central nervous system reactions.
- Sympathomimetics: Risk of hypertensive crisis when combined with decongestants or stimulants.
Alternatives to Rasagiline Mesylate
- Selegiline: Another MAO-B inhibitor used for Parkinson’s disease.
- Levodopa: Often combined with carbidopa for the treatment of Parkinson’s motor symptoms.
- Pramipexole: A dopamine agonist used to improve motor function in Parkinson’s disease.
