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Promethazine-DM
Promethazine-DM is a combination medication that contains promethazine hydrochloride, an antihistamine, and dextromethorphan hydrobromide (DM), a cough suppressant. This combination is used to relieve symptoms of allergies, motion sickness, and cough associated with colds or bronchial irritation. Promethazine works by blocking histamine receptors, reducing allergy symptoms, while dextromethorphan suppresses the cough reflex in the brain.
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Frequently Asked Questions
How long does it take for Promethazine-DM to start working?
Patients may start to feel relief from symptoms within 30 minutes to 1 hour after taking the medication.
Can I stop taking Promethazine-DM suddenly?
It is generally safe to stop taking Promethazine-DM abruptly, but consult your healthcare provider if you have been using it regularly.
Are there any dietary restrictions while taking Promethazine-DM?
There are no specific dietary restrictions; however, it is advisable to avoid alcohol while using this medication due to increased sedation.
What should I do if I miss a dose of Promethazine-DM?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
Is Promethazine-DM safe for children?
Promethazine-DM is not recommended for children under 2 years of age due to the risk of respiratory depression. Consult a healthcare provider for children over 2 years for appropriate dosing and safety.
Comprehensive Drug Guide
How Does Promethazine-DM Work?
- Promethazine works by blocking H1 receptors for histamine, alleviating symptoms such as itching, sneezing, and runny nose, as well as reducing nausea and motion sickness.
- Dextromethorphan acts on the cough center in the brain to suppress the cough reflex, providing relief from persistent cough.
What is Promethazine-DM Used For?
Common Dosages
- Syrup: Typically 6.25 mg of promethazine and 15 mg of dextromethorphan per 5 mL
Typical Dosing
- The usual dosage for adults and children over 12 years is 15 mL of syrup taken every 4 to 6 hours as needed, not exceeding 60 mL in 24 hours. Dosage for children under 12 should be determined by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Allergic rhinitis and other allergy symptoms
- Motion sickness
- Cough suppression due to colds or bronchial irritation
Who Shouldn't Take Promethazine-DM?
- Known hypersensitivity to promethazine, dextromethorphan, or any of the components
- Children under 2 years of age due to the risk of respiratory depression
- Severe respiratory depression or asthma
Advice From The Pharmacist
- Take Promethazine-DM as prescribed, and do not exceed the recommended dosage.
- Be cautious when driving or operating heavy machinery, as this medication can cause drowsiness or dizziness.
- Inform your healthcare provider about all medications and supplements you are taking, as there may be interactions.
Side Effects of Promethazine-DM
Common Side Effects
- Drowsiness or sedation
- Dizziness
- Dry mouth
- Nausea or vomiting
Uncommon/Severe Side Effects
- Respiratory depression (especially in young children)
- Severe allergic reactions (such as rash, swelling, or difficulty breathing)
Risks and Warnings of Promethazine-DM
- Respiratory Depression: Use caution in patients with a history of respiratory disorders, as promethazine can exacerbate these conditions.
- Sedation: Patients should be aware of the potential for sedation and should avoid alcohol and other CNS depressants while taking this medication.
- Dextromethorphan Misuse: Dextromethorphan has the potential for misuse, particularly in adolescents. It should be kept out of reach of children and used only as directed.
Interactions with Promethazine-DM
Common Drug Interactions
- CNS Depressants: Concurrent use with other sedatives, alcohol, or tranquilizers can enhance sedative effects and should be avoided.
- MAO Inhibitors: Patients taking MAO inhibitors should not use Promethazine-DM due to the risk of severe interactions.
Alternatives to Promethazine-DM
- Promethazine alone for allergy symptoms or motion sickness.
- Dextromethorphan as a standalone cough suppressant.
- Other antihistamines such as cetirizine or loratadine for allergy relief without the sedative effects.
