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Prodigen

Prodigen (ondansetron) is an antiemetic medication primarily used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking the action of serotonin, a neurotransmitter that can trigger nausea and vomiting, thereby helping patients manage these symptoms effectively.



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Frequently Asked Questions

How quickly does Prodigen start to work?
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Prodigen typically begins to relieve nausea and vomiting within 30 minutes of administration, especially when taken before chemotherapy or surgery.

Can I use Prodigen if I am pregnant or breastfeeding?
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Consult your healthcare provider before using Prodigen if you are pregnant or breastfeeding, to assess any potential risks.

Are there any specific dietary restrictions while using Prodigen?
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There are no specific dietary restrictions associated with the use of Prodigen, but maintaining a balanced diet can support overall health.

What should I do if I miss a dose of Prodigen?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Is Prodigen safe for long-term use?
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Prodigen is typically used for short-term management of nausea and vomiting. Long-term use should be monitored by a healthcare provider to assess effectiveness and any potential side effects. Regular follow-up appointments are important to ensure optimal management.

Comprehensive Drug Guide

How Does Prodigen Work?

  • Blocking serotonin receptors: It specifically antagonizes the serotonin 5-HT3 receptors in the central nervous system and the gastrointestinal tract. By inhibiting these receptors, Prodigen effectively reduces the signals that lead to nausea and vomiting.


Common Dosages

  • Oral tablets: Common strengths include 4 mg and 8 mg.
  • Orally disintegrating tablets: Usually available in 4 mg and 8 mg strengths.
  • Injectable solution: Commonly found in a concentration of 4 mg/2 mL.

Typical Dosing

  • For chemotherapy-induced nausea and vomiting: The typical oral dose is 8 mg taken 30 minutes before chemotherapy, followed by 8 mg every 8 hours for up to 24 hours post-treatment.
  • For postoperative nausea: The recommended dose may be 16 mg taken one hour before anesthesia induction.


Typical Dosing

FDA Approved Indications

  • Prevention of nausea and vomiting associated with:
  • Chemotherapy
  • Radiation therapy
  • Surgery
  • It may also be used for the treatment of nausea and vomiting in certain other clinical scenarios.


Who Shouldn't Take Prodigen?

  • Known hypersensitivity to ondansetron or any components of the formulation.
  • A history of serotonin syndrome with the use of serotonergic drugs.


Advice From The Pharmacist

  • Instruct patients on the importance of taking Prodigen before potential triggers of nausea, such as chemotherapy or surgery.
  • Advise patients to take the medication exactly as prescribed and to report any persistent nausea or vomiting despite treatment.
  • Discuss potential side effects, including headache, constipation, and dizziness, and encourage patients to report any severe or unusual symptoms.


Side Effects of Prodigen

Common Side Effects

  • Headache
  • Dizziness
  • Fatigue
  • Constipation
  • Diarrhea


Uncommon/Severe Side Effects

  • Severe allergic reactions (such as rash, itching, or difficulty breathing)
  • Symptoms of serotonin syndrome (such as agitation, hallucinations, rapid heart rate, or excessive sweating).


Risks and Warnings of Prodigen

  • Cardiac Effects: Ondansetron can cause dose-dependent QT prolongation, leading to serious cardiac arrhythmias. Caution is advised in patients with a history of cardiac arrhythmias or electrolyte imbalances.
  • Monitoring: Regular follow-up appointments may be necessary to monitor for potential complications, especially in patients with risk factors for cardiovascular disease.


Interactions with Prodigen

Common Drug Interactions

  • Other Medications: Patients should inform their healthcare provider about all medications they are taking, particularly other serotonergic medications, as this can increase the risk of serotonin syndrome or other interactions.


Alternatives to Prodigen

  • Other Antiemetics: Alternatives may include other anti-nausea medications such as granisetron, palonosetron, or metoclopramide, depending on individual patient needs and the specific situation.