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Pred-G

Pred-G (prednisolone acetate and gentamicin sulfate) is a combination medication used as a topical ophthalmic solution for the treatment of inflammatory conditions of the eye, particularly when there is a risk of bacterial infection. Prednisolone is a corticosteroid that reduces inflammation, while gentamicin is an antibiotic that helps prevent or treat bacterial infections in the eye.

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Frequently Asked Questions

How quickly does Pred-G start to work?

Patients may begin to notice relief from symptoms within a few hours of application, but full effects may take several days.

Can I stop taking Pred-G suddenly?

It is generally safe to discontinue Pred-G as directed by your healthcare provider; however, if you have been using it for an extended period, consult your provider for guidance.

Are there any specific dietary restrictions while taking Pred-G?

There are no specific dietary restrictions; however, maintaining a balanced diet can support overall health.

What should I do if I miss a dose of Pred-G?

If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Is Pred-G safe for long-term use?

Pred-G can be used safely for a limited duration under medical supervision. Regular monitoring for intraocular pressure and other potential side effects is essential for patients requiring long-term treatment.

Comprehensive Drug Guide

How Does Pred-G Work?

Prednisolone works by suppressing the inflammatory response in the eye by inhibiting the release of inflammatory mediators and decreasing immune system activity. Gentamicin, on the other hand, inhibits bacterial protein synthesis, leading to the death of susceptible bacteria, thereby addressing the potential for infection.

Common Dosages

Ophthalmic solution: 0.3% prednisolone acetate and 0.1% gentamicin sulfate.

Typical Dosing

The usual dosage is 1 to 2 drops in the affected eye(s) 2 to 4 times a day, depending on the severity of the condition. The frequency may be adjusted based on the clinical response.

Typical Dosing

FDA Approved Indications

Treatment of steroid-responsive inflammatory conditions of the eye when there is a risk of bacterial infection.

Who Shouldn't Take Pred-G?

Known hypersensitivity to prednisolone, gentamicin, or any components of the formulation.
Viral infections of the eye, including herpes simplex keratitis.
Fungal infections of the eye.

Advice From The Pharmacist

Instruct patients on the proper technique for administering eye drops to ensure effective delivery of the medication.
Advise patients to avoid touching the dropper tip to any surface, including the eye, to maintain sterility.
Monitor for any signs of worsening symptoms, such as increased redness or discharge, and instruct patients to seek medical attention if these occur.

Side Effects of Pred-G

Common Side Effects

Burning or stinging in the eye after application
Dryness of the eye
Increased tearing
Blurred vision

Uncommon/Severe Side Effects

Severe allergic reactions (such as rash, itching, or difficulty breathing)
Elevated intraocular pressure (which can lead to glaucoma)
Development of cataracts

Risks and Warnings of Pred-G

Intraocular Pressure: Long-term use of corticosteroids can lead to increased intraocular pressure; patients should be monitored regularly.
Cataract Formation: Prolonged use may increase the risk of cataracts, particularly in elderly patients or those with pre-existing risk factors.

Interactions with Pred-G

Common Drug Interactions

Other Ocular Medications: When using multiple ophthalmic medications, patients should be advised to wait at least 5 minutes between different medications to avoid dilution or inactivation.

Alternatives to Pred-G

Other Topical Corticosteroids: Such as fluorometholone or dexamethasone, may be considered for similar indications depending on the condition being treated.
Other Antibiotic Drops: May be used if infection is the primary concern without the need for steroid therapy.