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Pifeltro
Pifeltro (doravirine) is an antiretroviral medication used in the treatment of HIV-1 infection in adults. It is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of the HIV virus. By blocking this enzyme, Pifeltro helps to lower the viral load in the body, thereby improving immune function and reducing the risk of HIV-related complications.
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Frequently Asked Questions
How quickly does Pifeltro start to work?
Patients may start to see a reduction in viral load within weeks of starting treatment, but it is essential to continue taking the medication as prescribed for optimal results.
Can I stop taking Pifeltro suddenly?
It is not advisable to stop taking Pifeltro abruptly without consulting your healthcare provider, as this can lead to viral rebound and resistance.
Are there any specific dietary restrictions while taking Pifeltro?
There are no specific dietary restrictions associated with Pifeltro; however, maintaining a healthy lifestyle is recommended to support overall health.
What should I do if I miss a dose of Pifeltro?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Pifeltro safe for long-term use?
Pifeltro can be used long-term under medical supervision. Regular follow-up appointments are essential for monitoring viral load, liver function, and overall treatment efficacy.
Comprehensive Drug Guide
How Does Pifeltro Work?
Doravirine works by binding to and inhibiting the activity of reverse transcriptase, an enzyme crucial for the conversion of viral RNA into DNA. This inhibition prevents the integration of viral DNA into the host's genome, thereby interrupting the replication cycle of the HIV virus and reducing the viral load.
Common Dosages
- Tablets: 100 mg.
Typical Dosing
- The usual recommended dose is 100 mg taken orally once daily, with or without food. It can be administered alone or as part of a combination therapy with other antiretroviral agents.
Typical Dosing
FDA Approved Indications
- Treatment of HIV-1 infection in adults as part of a combination antiretroviral regimen.
Who Shouldn't Take Pifeltro?
- Known hypersensitivity to doravirine or any components of the formulation.
- Concomitant use with certain medications that are strong inducers of CYP3A4, which can significantly decrease doravirine levels.
Advice From The Pharmacist
- Instruct patients to take Pifeltro exactly as prescribed and to adhere to their medication regimen to maintain viral suppression.
- Encourage patients to inform their healthcare provider of all medications they are taking to avoid potential drug interactions.
- Advise patients about the importance of regular follow-up appointments for monitoring viral load and overall health.
Side Effects of Pifeltro
Common Side Effects
- Fatigue
- Nausea
- Diarrhea
- Headache
- Insomnia
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Hepatotoxicity (elevated liver enzymes)
Risks and Warnings of Pifeltro
- Hepatic Function: Monitor liver function tests regularly, as doravirine can cause elevations in liver enzymes.
- Drug Interactions: Assess for potential interactions with other medications, particularly those that may affect CYP3A4 activity.
Interactions with Pifeltro
Common Drug Interactions
- CYP3A4 Inducers: Medications such as rifampin or St. John's Wort may significantly decrease doravirine levels, requiring dose adjustments or alternative therapies.
- Other Antiretrovirals: Careful monitoring is necessary when used in combination with other antiretrovirals to ensure efficacy and minimize side effects.
Alternatives to Pifeltro
- Other NNRTIs: Such as efavirenz or rilpivirine may be considered based on the patient’s specific treatment needs and resistance profiles.
- Integrase Inhibitors: Such as dolutegravir or bictegravir can also be options for HIV treatment.
