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Perseris
Perseris (risperidone) is a long-acting injectable formulation used primarily for the treatment of schizophrenia in adults and adolescents aged 16 years and older. It is administered once a month and is designed to improve adherence to treatment by providing a stable release of the medication over time.
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Frequently Asked Questions
How quickly does Perseris work?
Patients may begin to notice improvements in symptoms within a few weeks, but optimal effects may take longer.
Can I take Perseris with other medications?
Always inform your healthcare provider about all medications you are taking to avoid potential interactions.
What should I do if I miss a dose?
If you miss a scheduled dose, contact your healthcare provider for guidance on rescheduling the next dose.
Is Perseris safe during pregnancy?
Consult your healthcare provider before using Perseris during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions, changes in mood or behavior, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Perseris Work?
- Dopamine D2 receptors: Reducing symptoms of psychosis and improving mood.
- Serotonin 5-HT2A receptors: Enhancing mood and reducing anxiety.
Common Dosages
- Injection: Available in pre-filled syringes, commonly in strengths of 90 mg and 120 mg.
Typical Dosing
- Adults and Adolescents: The recommended initial dose is typically 90 mg administered intramuscularly, followed by a maintenance dose of either 90 mg or 120 mg once a month, depending on the patient's clinical response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of schizophrenia in adults and adolescents aged 16 years and older.
Who Shouldn't Take Perseris?
- Known hypersensitivity to risperidone or any component of the formulation.
- A history of severe hypersensitivity reactions to the medication.
Advice From The Pharmacist
- Perseris is intended for intramuscular injection only; ensure proper administration technique to avoid complications.
- Monitor for any side effects, particularly those related to metabolic changes, such as weight gain or changes in glucose levels.
- Regular follow-up appointments are essential to assess effectiveness and adjust dosing as necessary.
Side Effects of Perseris
Common Side Effects
- Weight gain
- Sedation or drowsiness
- Anxiety
- Injection site reactions (pain, redness, swelling)
Uncommon/Severe Side Effects
- Extrapyramidal symptoms (tremors, rigidity)
- Neuroleptic malignant syndrome (NMS)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Perseris
- Metabolic Effects: Monitor weight, glucose, and lipid levels regularly, as risperidone can increase the risk of metabolic syndrome.
- Cognitive and Motor Impairment: Caution is advised when driving or operating heavy machinery until you know how Perseris affects you.
Interactions with Perseris
Common Drug Interactions
- CNS Depressants: Use caution when combined with other medications that cause sedation or drowsiness.
- Antihypertensives: Monitor blood pressure closely, as risperidone may enhance the effects of blood pressure-lowering medications.
Alternatives to Perseris
- Other Atypical Antipsychotics: Such as aripiprazole, quetiapine, or olanzapine for similar indications.
- Oral Formulations of Risperidone: For patients who prefer oral medication or require flexible dosing.
