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Paser
Paser (phenelzine sulfate) is a monoamine oxidase inhibitor (MAOI) primarily used for the treatment of depression. It is particularly effective in cases of atypical depression and can also be used for anxiety disorders.
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Frequently Asked Questions
How quickly does Paser work?
Patients may begin to notice improvements in their depressive symptoms within 2 to 4 weeks, but it may take longer to achieve optimal effects.
Can I take Paser with food?
Yes, but be cautious about tyramine-rich foods, which should be avoided to prevent hypertensive crises.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Is Paser safe during pregnancy?
Paser should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for symptoms such as severe allergic reactions or signs of hypertensive crisis, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Paser Work?
Phenelzine works by inhibiting the enzyme monoamine oxidase, which is responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. By preventing this breakdown, phenelzine increases the levels of these neurotransmitters, helping to improve mood and alleviate depressive symptoms.
Common Dosages
- Tablets: Common strength is 15 mg.
Typical Dosing
- Adults: The usual recommended starting dose is 15 mg taken three times daily, with a gradual increase based on clinical response. The maximum recommended dose is typically 60 mg per day.
Typical Dosing
FDA Approved Indications
- Treatment of major depressive disorder.
- Treatment of anxiety disorders.
Who Shouldn't Take Paser?
- Known hypersensitivity to phenelzine or any component of the formulation.
- Severe liver disease, cardiovascular disease, or pheochromocytoma.
- Concurrent use of certain medications, including other antidepressants or stimulants.
Advice From The Pharmacist
- Take Paser exactly as prescribed, and do not stop taking it abruptly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
- Follow a strict diet to avoid tyramine-rich foods (e.g., aged cheeses, cured meats), which can trigger hypertensive crises when taken with MAOIs.
- Monitor for any changes in mood, behavior, or significant side effects, and report these to your healthcare provider.
Side Effects of Paser
Common Side Effects
- Dizziness
- Drowsiness
- Dry mouth
- Nausea
- Weight gain
Uncommon/Severe Side Effects
- Severe hypertensive crisis (symptoms may include severe headache, chest pain, and increased heart rate)
- Liver damage
- Allergic reactions (rash, itching, swelling)
Risks and Warnings of Paser
- Dietary Restrictions: Follow dietary restrictions strictly to avoid dangerous interactions with tyramine-rich foods.
- Drug Interactions: Be cautious when combining with other medications, especially those that may increase serotonin levels.
Interactions with Paser
Common Drug Interactions
- Tyramine-rich Foods: Avoid foods high in tyramine to prevent hypertensive crises.
- Other Medications: Inform your healthcare provider about all medications you are taking, especially other antidepressants or sympathomimetics, to avoid potential interactions.
Alternatives to Paser
- Other Antidepressants: Such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) for similar indications.
- Psychotherapy: Cognitive behavioral therapy (CBT) or other therapeutic approaches may also be considered.
