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Phenelzine Sulfate
Phenelzine sulfate is a monoamine oxidase inhibitor (MAOI) used primarily for the treatment of depression, particularly in cases where other antidepressants have not been effective. It is also sometimes used for anxiety disorders, including social anxiety disorder and panic disorder.
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Frequently Asked Questions
How quickly does phenelzine work?
Patients may begin to notice improvements in depressive symptoms within 2 to 4 weeks, but it may take longer to achieve optimal effects.
Can I take phenelzine with food?
Yes, but be cautious about tyramine-rich foods, which should be avoided to prevent hypertensive crises.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Is phenelzine safe during pregnancy?
Consult your healthcare provider before using phenelzine during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for signs of hypertensive crisis or severe allergic reactions, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Phenelzine Sulfate Work?
Phenelzine works by inhibiting the enzyme monoamine oxidase, which breaks down neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. By preventing this breakdown, phenelzine increases the levels of these neurotransmitters, which can help improve mood and alleviate symptoms of depression.
Common Dosages
- Tablets: Common strength is 15 mg.
Typical Dosing
- Adults: The usual recommended starting dose is 15 mg taken three times daily. The dose may be gradually increased, with a typical maximum dose of 60 mg per day.
Typical Dosing
FDA Approved Indications
- Treatment of major depressive disorder.
- Treatment of anxiety disorders, including social anxiety disorder.
Who Shouldn't Take Phenelzine Sulfate?
- Known hypersensitivity to phenelzine or any component of the formulation.
- History of pheochromocytoma (a type of tumor).
- Cardiovascular disease or severe liver disease.
Advice From The Pharmacist
- Take phenelzine exactly as prescribed, and do not stop taking it abruptly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
- Follow a strict diet to avoid tyramine-rich foods (e.g., aged cheeses, cured meats, fermented products), as they can trigger hypertensive crises when taken with MAOIs.
- Monitor for any changes in mood, behavior, or blood pressure, and report these to your healthcare provider.
Side Effects of Phenelzine Sulfate
Common Side Effects
- Dizziness
- Drowsiness
- Dry mouth
- Constipation
- Weight gain
Uncommon/Severe Side Effects
- Dietary Restrictions: Follow dietary restrictions strictly to avoid dangerous interactions with tyramine-rich foods.
- Drug Interactions: Be cautious when combining with other medications, especially other antidepressants, stimulants, or certain pain medications.
Risks and Warnings of Phenelzine Sulfate
- Dietary Restrictions: Follow dietary restrictions strictly to avoid dangerous interactions with tyramine-rich foods.
- Drug Interactions: Be cautious when combining with other medications, especially other antidepressants, stimulants, or certain pain medications.
Interactions with Phenelzine Sulfate
Common Drug Interactions
- Tyramine-rich Foods: Avoid foods high in tyramine to prevent hypertensive crises.
- Other Medications: Inform your healthcare provider about all medications you are taking, especially other antidepressants, to avoid potential interactions.
Alternatives to Phenelzine Sulfate
- Other Antidepressants: Such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs).
- Psychotherapy: Cognitive behavioral therapy (CBT) or other therapeutic approaches may also be considered.
