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Pancreaze
Pancreaze is a pancreatic enzyme replacement therapy used to treat exocrine pancreatic insufficiency (EPI) due to conditions such as cystic fibrosis, chronic pancreatitis, or surgical removal of the pancreas. It contains a combination of digestive enzymes, including lipase, amylase, and protease, which help in the digestion and absorption of nutrients from food.
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Frequently Asked Questions
How quickly does Pancreaze work?
Patients typically notice improvements in digestion and reduction in gastrointestinal symptoms within a few days of starting treatment.
Can I take Pancreaze with food?
Yes, Pancreaze should be taken with meals for optimal effectiveness in digesting food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember during the meal. If it's almost time for your next meal, skip the missed dose and continue with your regular schedule. Do not double up.
Is Pancreaze safe during pregnancy?
Pancreaze should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for any signs of allergic reactions, significant gastrointestinal distress, or changes in bowel habits, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Pancreaze Work?
Pancreaze works by providing the necessary digestive enzymes that the pancreas is unable to produce adequately in patients with EPI. The enzymes help break down fats, carbohydrates, and proteins in food, facilitating proper digestion and nutrient absorption.
Common Dosages
- Delayed-release capsules containing varying strengths of lipase, amylase, and protease.
Typical Dosing
- Adults and Children: The recommended starting dose is typically based on the amount of lipase, usually 1000 to 2500 units of lipase per meal, with adjustments made based on individual nutritional needs and tolerance.
Typical Dosing
FDA Approved Indications
- Treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, or other conditions.
Who Shouldn't Take Pancreaze?
- Known hypersensitivity to pancrelipase or any component of the formulation
- History of pancreatitis exacerbated by enzyme therapy
Advice From The Pharmacist
- Take Pancreaze with meals to enhance the effectiveness of the enzymes.
- Swallow the capsules whole; do not crush or chew them to ensure the enzymes are released in the intestine.
- Monitor for any gastrointestinal symptoms, such as abdominal pain or diarrhea, and report any concerns to your healthcare provider.
Side Effects of Pancreaze
Common Side Effects
- Gastrointestinal symptoms (nausea, diarrhea, abdominal pain)
- Headache
Uncommon/Severe Side Effects
- Allergic reactions (rash, itching, swelling)
- Fibrosing colonopathy (a rare condition that can occur with high doses)
Risks and Warnings of Pancreaze
- Allergic Reactions: Monitor for signs of an allergic reaction and seek immediate medical attention if severe symptoms occur.
- Gastrointestinal Monitoring: Regularly assess for any changes in gastrointestinal symptoms or bowel habits, especially if symptoms worsen.
Interactions with Pancreaze
Common Drug Interactions
- Antacids: Use with caution, as some antacids may affect the absorption of Pancreaze. Consult your healthcare provider for advice on concurrent use.
- Other Medications: Inform your healthcare provider about all medications you are taking to avoid potential interactions.
Alternatives to Pancreaze
- Other Pancreatic Enzyme Products: Such as Creon or Zenpep for similar indications.
- Nutritional Support: Dietary adjustments or nutritional supplements may be recommended based on individual needs.
