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Creon
Creon (generic name: pancrelipase) is a pancreatic enzyme replacement therapy used to treat people who cannot digest food properly because their pancreas does not produce enough enzymes. This condition is called exocrine pancreatic insufficiency (EPI) and can occur in diseases like cystic fibrosis, chronic pancreatitis, or following pancreatic surgery. Creon contains a mix of pancreatic enzymes including lipase, protease, and amylase, which help digest fats, proteins, and carbohydrates, improving nutrient absorption and digestion.
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Frequently Asked Questions
How long does it take for Creon to work?
Creon begins working as soon as it reaches the small intestine and releases the digestive enzymes, so it works immediately with the meal it's taken with.
Can I open the Creon capsule and sprinkle it on food?
Yes, if you have difficulty swallowing capsules, you can sprinkle the contents on a small amount of soft food like applesauce. Do not crush or chew the granules.
What happens if I miss a dose of Creon?
If you miss a dose, take it as soon as you remember, but if it’s almost time for the next meal or snack, skip the missed dose. Do not double up doses.
Can I take Creon with drinks instead of food?
Creon should be taken with meals or snacks that contain fat, as the enzymes help digest food. Taking it without food may not be effective.
Is Creon safe for long-term use?
Yes, Creon is generally safe for long-term use when taken as prescribed. Regular check-ups with your healthcare provider are recommended to ensure the correct dosage.
Comprehensive Drug Guide
How Does Creon Work?
Creon works by providing digestive enzymes that the pancreas is unable to produce. The enzymes contained in Creon (lipase, amylase, and protease) are released in the small intestine where they break down fats, proteins, and carbohydrates, enabling better digestion and nutrient absorption.
Common Dosages
- 3,000 lipase units
- 6,000 lipase units
- 12,000 lipase units
- 24,000 lipase units
- 36,000 lipase units
Typical Dosing
- The dose of Creon is individualized based on the severity of enzyme deficiency and the amount of fat in the diet.
- Typical starting doses range from 500 to 2,500 lipase units per kilogram of body weight per meal.
- Creon is usually taken with every meal and snack, with the dosage adjusted by your healthcare provider based on response.
Typical Dosing
FDA Approved Indications
- Cystic fibrosis
- Chronic pancreatitis
- Pancreatectomy (surgical removal of the pancreas)
- Pancreatic cancer
- Other conditions causing a lack of pancreatic enzymes
Who Shouldn't Take Creon?
- Known hypersensitivity to pork proteins, as Creon is derived from pig pancreas
- Acute pancreatitis, during the early stages of inflammation
Advice From The Pharmacist
- Take Creon with every meal or snack, ensuring that you do not skip doses to aid proper digestion.
- Swallow the capsules whole, without crushing or chewing them, as this could affect how the enzymes are released.
- Store Creon at room temperature and protect the capsules from moisture.
Side Effects of Creon
Common Side Effects
- Bloating or gas
- Stomach pain
- Diarrhea or constipation
- Nausea
Uncommon/Severe Side Effects
- Fibrosing colonopathy (a rare condition involving the thickening of the colon wall)
- Allergic reactions (especially in individuals allergic to pork proteins)
Risks and Warnings of Creon
- Fibrosing Colonopathy: High doses of Creon over extended periods can increase the risk of fibrosing colonopathy, particularly in individuals with cystic fibrosis.
- Allergic Reactions: Creon contains enzymes derived from pigs, and individuals allergic to pork should avoid this medication.
Interactions with Creon
Common Drug Interactions
- There are no significant known drug interactions with Creon. However, always inform your healthcare provider of any other medications or supplements you are taking.
Alternatives to Creon
- Zenpep: Another pancreatic enzyme replacement therapy similar to Creon.
- Pancreaze: A pancreatic enzyme product used to treat exocrine pancreatic insufficiency.
- Pertzye: Another option for pancreatic enzyme replacement therapy, often used in cystic fibrosis.
