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Paliperidone ER
Paliperidone ER is an atypical antipsychotic medication primarily used for the treatment of schizophrenia and for managing symptoms of schizoaffective disorder. It is the active metabolite of risperidone and helps to stabilize mood and reduce the severity of psychotic symptoms.
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Frequently Asked Questions
How quickly does Paliperidone ER work?
Patients may start to notice improvements in their symptoms within 1 to 2 weeks, but it may take several weeks to achieve the full therapeutic effect.
Can I take Paliperidone ER with food?
Yes, it can be taken with or without food, but it should be taken consistently in the same manner.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while using Paliperidone ER?
There are no specific dietary restrictions, but maintaining a balanced diet is advisable.
Is Paliperidone ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Paliperidone ER during these periods.
Comprehensive Drug Guide
How Does Paliperidone ER Work?
Paliperidone works by modulating the effects of neurotransmitters in the brain, primarily by blocking dopamine D2 and serotonin 5-HT2A receptors. This dual action helps reduce symptoms of schizophrenia, such as hallucinations and delusions, and improves overall emotional stability.
Common Dosages
- Extended-Release Tablets: Common strengths include 3 mg, 6 mg, 9 mg, and 12 mg.
Typical Dosing
- The recommended starting dose for adults is 6 mg once daily, which may be adjusted based on response, typically ranging from 3 mg to 12 mg daily.
Typical Dosing
FDA Approved Indications
- Schizophrenia: for the treatment of schizophrenia in adults and adolescents aged 12 and older.
- Schizoaffective Disorder: for the treatment of schizoaffective disorder.
Who Shouldn't Take Paliperidone ER?
- Known hypersensitivity to paliperidone or any component of the formulation.
- Severe renal impairment (creatinine clearance < 10 mL/min).
Advice From The Pharmacist
- Take Paliperidone ER exactly as prescribed; do not crush or chew the tablets, as this can affect the extended-release mechanism.
- It may take several weeks to notice the full therapeutic effects.
- Monitor for any changes in mood, behavior, or worsening of symptoms, particularly during the initial treatment period.
Side Effects of Paliperidone ER
Common Side Effects
- Drowsiness
- Weight gain
- Increased appetite
- Fatigue
- Akathisia (restlessness)
Uncommon/Severe Side Effects
- Neuroleptic Malignant Syndrome (NMS)
- Tardive dyskinesia (involuntary movements)
- Hyperglycemia or diabetes mellitus.
Risks and Warnings of Paliperidone ER
- Metabolic Changes: Monitor weight and metabolic parameters regularly, as paliperidone can lead to weight gain and increased blood sugar levels.
- Cognitive Effects: Assess cognitive and motor skills, especially in older adults, as there is an increased risk of falls.
Interactions with Paliperidone ER
Common Drug Interactions
- Other CNS Depressants: Use with caution when combined with other central nervous system depressants, as this may enhance sedative effects.
- Dopamine Agonists: Avoid concurrent use with medications that act as dopamine agonists.
Alternatives to Paliperidone ER
- Other Atypical Antipsychotics: Such as risperidone, quetiapine, or aripiprazole for similar indications.
- Conventional Antipsychotics: In certain cases, conventional antipsychotics may be considered based on patient history and response.
